(7 nodes) (2022) A Severe Dementia Syndrome Caused by Intron Retention and Cryptic Splice Site Activation in STUB1 and Exacerbated by TBP Repeat Expansions. network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Prnp	Major prion protein; Belongs to the prion family. (254 aa)
	Stub1	STIP1-likey and U box-containing protein 1. (231 aa)
	Psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	Psen2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
	Atxn3	Ataxin-3. (307 aa)
	Tardbp	TAR DNA-binding protein 43. (199 aa)
	App	Amyloid beta A4 protein. (433 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
App	Prnp	G3HMG4	G3H416	Amyloid beta A4 protein.	Major prion protein; Belongs to the prion family.	0.924
App	Psen1	G3HMG4	G3HNF2	Amyloid beta A4 protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.971
App	Psen2	G3HMG4	G3HV76	Amyloid beta A4 protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.906
Atxn3	Stub1	G3I1H9	G3HBU2	Ataxin-3.	STIP1-likey and U box-containing protein 1.	0.772
Atxn3	Tardbp	G3I1H9	G3I5W2	Ataxin-3.	TAR DNA-binding protein 43.	0.413
Prnp	App	G3H416	G3HMG4	Major prion protein; Belongs to the prion family.	Amyloid beta A4 protein.	0.924
Prnp	Psen1	G3H416	G3HNF2	Major prion protein; Belongs to the prion family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.669
Prnp	Psen2	G3H416	G3HV76	Major prion protein; Belongs to the prion family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.554
Prnp	Tardbp	G3H416	G3I5W2	Major prion protein; Belongs to the prion family.	TAR DNA-binding protein 43.	0.518
Psen1	App	G3HNF2	G3HMG4	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Amyloid beta A4 protein.	0.971
Psen1	Prnp	G3HNF2	G3H416	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Major prion protein; Belongs to the prion family.	0.669
Psen1	Psen2	G3HNF2	G3HV76	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.998
Psen2	App	G3HV76	G3HMG4	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Amyloid beta A4 protein.	0.906
Psen2	Prnp	G3HV76	G3H416	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Major prion protein; Belongs to the prion family.	0.554
Psen2	Psen1	G3HV76	G3HNF2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.998
Stub1	Atxn3	G3HBU2	G3I1H9	STIP1-likey and U box-containing protein 1.	Ataxin-3.	0.772
Tardbp	Atxn3	G3I5W2	G3I1H9	TAR DNA-binding protein 43.	Ataxin-3.	0.413
Tardbp	Prnp	G3I5W2	G3H416	TAR DNA-binding protein 43.	Major prion protein; Belongs to the prion family.	0.518