(59 nodes) (2022) The pathogenicity and virulence of Leishmania - interplay of virulence factors with host defenses. network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Hif1a	Hypoxia-inducible factor 1 alpha. (820 aa)
	I79_016240	Beclin-1. (119 aa)
	Xpo5	Exportin-5. (1204 aa)
	I79_015487	Elongation factor 1-alpha 1. (458 aa)
	CgPICR_014700	C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (373 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
	Smad4	Mothers against decapentaplegic-like 4. (259 aa)
	Bcap31	B-cell receptor-associated protein 31. (245 aa)
	Irak1	Interleukin-1 receptor-associated kinase 1. (494 aa)
	Myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	Smad7	Mothers against decapentaplegic-like 7. (256 aa)
	Vamp8	Vesicle-associated membrane protein 8. (101 aa)
	Brd4	Bromodomain-containing protein 4. (723 aa)
	Becn1	Beclin-1. (448 aa)
	Lamp1	Lysosome-associated membrane glycoprotein 1. (370 aa)
	Eef1a2	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (463 aa)
	I79_009796	Plasminogen; Belongs to the peptidase S1 family. Plasminogen subfamily. (697 aa)
	Abcc1	Multidrug resistance-associated protein 1. (146 aa)
	Bcl2	Apoptosis regulator Bcl-2. (203 aa)
	Mapk8ip3	C-jun-amino-terminal kinase-interacting protein 3. (1073 aa)
	Il10	Interleukin-10. (178 aa)
	Hdac1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
	Socs3	Suppressor of cytokine signaling 3. (225 aa)
	I79_004417	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	Il18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
	Arg2	Arginase. (305 aa)
	Ctsb	Cathepsin B; Belongs to the peptidase C1 family. (339 aa)
	Map2k4	Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (342 aa)
	Traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (508 aa)
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	Src	Tyrosine-protein kinase. (536 aa)
	Ezh2	Histone-lysine N-methyltransferase EZH2. (746 aa)
	I79_001600	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
	Cd163	Scavenger receptor cysteine-rich type 1 protein M130. (497 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)
	CgPICR_005092	B-cell receptor-associated protein 31. (245 aa)
	Smyd2	SET and MYND domain-containing protein 2. (326 aa)
	Bak1	Bcl-2-likeous antagonist/killer. (209 aa)
	Tlr6	Toll-like receptor. (795 aa)
	I79_025440	Cathepsin L1; Belongs to the peptidase C1 family. (333 aa)
	Tlr3	Toll-like receptor 3. (164 aa)
	Eef1a1	Elongation factor 1-alpha 1. (262 aa)
	CgPICR_017379	Toll-like receptor 11. (916 aa)
	Ppara	Peroxisome proliferator-activated receptor alpha. (393 aa)
	I79_022257	Actin. (98 aa)
	Jak2	Tyrosine-protein kinase. (1122 aa)
	Mtor	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
	Irak4	Interleukin-1 receptor-associated kinase 4. (462 aa)
	Tlr7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1033 aa)
	Stat1	Signal transducer and activator of transcription. (749 aa)
	Ccl5	C-C motif chemokine. (91 aa)
	CgPICR_017737	Lysosome-associated membrane glycoprotein 1. (403 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (813 aa)
	I79_018057	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
	Tab1	Mitogen-activated protein kinase kinase kinase 7-interacting protein 1. (336 aa)
	Cd80	T-lymphocyte activation antigen CD80. (177 aa)
	Tlr4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	Foxo1	Forkhead box protein O1. (469 aa)
	Dicer1	Endoribonuclease Dicer; Belongs to the helicase family. Dicer subfamily. (1907 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	Cd4	G3I7E3	G3GUN9	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	T-cell surface glycoprotein CD4.	0.492
AGO2	Dicer1	G3I7E3	G3HZ70	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Endoribonuclease Dicer; Belongs to the helicase family. Dicer subfamily.	0.987
AGO2	Irak1	G3I7E3	G3HSV4	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Interleukin-1 receptor-associated kinase 1.	0.511
AGO2	Xpo5	G3I7E3	G3HYU7	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Exportin-5.	0.886
Arg2	Cd4	G3H1L8	G3GUN9	Arginase.	T-cell surface glycoprotein CD4.	0.803
Arg2	Ifng	G3H1L8	G3GY20	Arginase.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.580
Arg2	Il10	G3H1L8	G3HB01	Arginase.	Interleukin-10.	0.754
Bak1	Bcl2	A1E3K4	G3HD46	Bcl-2-likeous antagonist/killer.	Apoptosis regulator Bcl-2.	0.980
Bak1	I79_001600	A1E3K4	G3GV69	Bcl-2-likeous antagonist/killer.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.969
Bak1	I79_004417	A1E3K4	G3H2K2	Bcl-2-likeous antagonist/killer.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.968
Bak1	I79_018057	A1E3K4	G3I3P7	Bcl-2-likeous antagonist/killer.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.968
Bcap31	CgPICR_005092	G3HSX3	G3GTA2	B-cell receptor-associated protein 31.	B-cell receptor-associated protein 31.	0.900
Bcl2	Bak1	G3HD46	A1E3K4	Apoptosis regulator Bcl-2.	Bcl-2-likeous antagonist/killer.	0.980
Bcl2	Becn1	G3HD46	G3HLZ1	Apoptosis regulator Bcl-2.	Beclin-1.	0.997
Bcl2	Cd4	G3HD46	G3GUN9	Apoptosis regulator Bcl-2.	T-cell surface glycoprotein CD4.	0.574
Bcl2	Ctsb	G3HD46	G3H0L9	Apoptosis regulator Bcl-2.	Cathepsin B; Belongs to the peptidase C1 family.	0.919
Bcl2	Hif1a	G3HD46	G3HZ04	Apoptosis regulator Bcl-2.	Hypoxia-inducible factor 1 alpha.	0.441
Bcl2	I79_001600	G3HD46	G3GV69	Apoptosis regulator Bcl-2.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.993
Bcl2	I79_004417	G3HD46	G3H2K2	Apoptosis regulator Bcl-2.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.994
Bcl2	I79_016240	G3HD46	G3HYU8	Apoptosis regulator Bcl-2.	Beclin-1.	0.977