(37 nodes) (2022) Using GPCRs as Molecular Beacons to Target Ovarian Cancer with Nanomedicines. network (Cricetulus griseus)

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second shell of interactors

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Predicted Interactions

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Your Input:
	Cxcl12	Stromal cell-derived factor 1. (89 aa)
	Sst	Somatostatin. (116 aa)
	Hrh1	Histamine H1 receptor; Belongs to the G-protein coupled receptor 1 family. (489 aa)
	Tp53	Cellular tumor antigen p53. (148 aa)
	I79_002785	Beta-arrestin-2. (65 aa)
	Ctla4	Cytotoxic T-lymphocyte protein 4. (171 aa)
	Gpr39	G-protein coupled receptor 39; Belongs to the G-protein coupled receptor 1 family. (289 aa)
	Cxcr4	C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (290 aa)
	Edn1	Endothelin-1. (202 aa)
	Oxtr	Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (353 aa)
	Tcf7	Transcription factor 7. (213 aa)
	Drd2	D(2) dopamine receptor. (274 aa)
	F2r	Proteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (396 aa)
	Lpar2	Lysophosphatidic acid receptor 2. (50 aa)
	Lgr5	Leucine-rich repeat-containing G-protein coupled receptor 5. (555 aa)
	I79_005341	Parathyroid hormone 2 receptor; Belongs to the G-protein coupled receptor 2 family. (375 aa)
	FSHR	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (487 aa)
	Cck	Cholecystokinin. (115 aa)
	Ednra	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (412 aa)
	Ntsr1	Neurotensin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
	I79_010864	Growth hormone-releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (372 aa)
	Brca1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1790 aa)
	Grp	Gastrin-releasing peptide. (75 aa)
	Gper1	G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	Rho	Rhodopsin. (348 aa)
	Grpr	Gastrin-releasing peptide receptor; Belongs to the G-protein coupled receptor 1 family. (384 aa)
	Agtr1	Type-1A angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	Gpr68	Ovarian cancer G-protein coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
	Cxcl1	C-X-C motif chemokine. (101 aa)
	Sstr1	Somatostatin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	Lpar3	Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	Cckar	Cholecystokinin receptor type A. (205 aa)
	Cckbr	Gastrin/cholecystokinin type B receptor; Belongs to the G-protein coupled receptor 1 family. (418 aa)
	Folr1	Folate receptor alpha. (257 aa)
	I79_023904	Formyl peptide receptor 2; Belongs to the G-protein coupled receptor 1 family. (350 aa)
	Cxcr2	High affinity interleukin-8 receptor B; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	Plk1	Serine/threonine-protein kinase PLK. (602 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Agtr1	Cck	G3I0U1	G3H992	Type-1A angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family.	Cholecystokinin.	0.504
Agtr1	Edn1	G3I0U1	G3H0G9	Type-1A angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family.	Endothelin-1.	0.622
Agtr1	Ednra	G3I0U1	G3H9A8	Type-1A angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family.	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family.	0.456
Agtr1	F2r	G3I0U1	G3H330	Type-1A angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family.	Proteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.920
Agtr1	I79_002785	G3I0U1	G3GYB1	Type-1A angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family.	Beta-arrestin-2.	0.696
Agtr1	Lpar2	G3I0U1	G3H462	Type-1A angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family.	Lysophosphatidic acid receptor 2.	0.910
Agtr1	Lpar3	G3I0U1	G3IAR4	Type-1A angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family.	Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.905
Agtr1	Sst	G3I0U1	G3GT93	Type-1A angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family.	Somatostatin.	0.479
Brca1	Plk1	G3HM05	G3IN30	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Serine/threonine-protein kinase PLK.	0.781
Brca1	Tp53	G3HM05	G3GY68	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Cellular tumor antigen p53.	0.980
Cck	Agtr1	G3H992	G3I0U1	Cholecystokinin.	Type-1A angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family.	0.504
Cck	Cckar	G3H992	G3ICF8	Cholecystokinin.	Cholecystokinin receptor type A.	0.998
Cck	Cckbr	G3H992	G3IEE3	Cholecystokinin.	Gastrin/cholecystokinin type B receptor; Belongs to the G-protein coupled receptor 1 family.	0.999
Cck	Edn1	G3H992	G3H0G9	Cholecystokinin.	Endothelin-1.	0.402
Cck	Ednra	G3H992	G3H9A8	Cholecystokinin.	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family.	0.599
Cck	Grp	G3H992	G3HSD0	Cholecystokinin.	Gastrin-releasing peptide.	0.882
Cck	Grpr	G3H992	G3HXH5	Cholecystokinin.	Gastrin-releasing peptide receptor; Belongs to the G-protein coupled receptor 1 family.	0.554
Cck	Ntsr1	G3H992	G3HGX1	Cholecystokinin.	Neurotensin receptor type 1; Belongs to the G-protein coupled receptor 1 family.	0.561
Cck	Oxtr	G3H992	G3H112	Cholecystokinin.	Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	0.498
Cck	Rho	G3H992	G3HVL9	Cholecystokinin.	Rhodopsin.	0.655