(10 nodes) (2022) Functional Studies of Genetic Variants Associated with Human Diseases in Notch Signaling-Related Genes Using Drosophila. network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Adam10	Disintegrin and metalloproteinase domain-containing protein 10. (675 aa)
	Jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1186 aa)
	Lfng	Beta-1,3-N-acetylglucosaminyltransferase. (378 aa)
	Tm2d3	TM2 domain-containing protein 3. (182 aa)
	Psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	Dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (741 aa)
	Notch2	Neurogenic locus notch-like protein 2. (1521 aa)
	Psen2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
	Larp7	La-related protein 7. (217 aa)
	Rbpj	Recombining binding protein suppressor of hairless-like protein. (486 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adam10	Dll1	G3GRM2	G3HNT7	Disintegrin and metalloproteinase domain-containing protein 10.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.698
Adam10	Jag1	G3GRM2	G3GSA7	Disintegrin and metalloproteinase domain-containing protein 10.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.553
Adam10	Notch2	G3GRM2	G3HP78	Disintegrin and metalloproteinase domain-containing protein 10.	Neurogenic locus notch-like protein 2.	0.523
Adam10	Psen1	G3GRM2	G3HNF2	Disintegrin and metalloproteinase domain-containing protein 10.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.781
Adam10	Psen2	G3GRM2	G3HV76	Disintegrin and metalloproteinase domain-containing protein 10.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.719
Adam10	Rbpj	G3GRM2	G3ICG1	Disintegrin and metalloproteinase domain-containing protein 10.	Recombining binding protein suppressor of hairless-like protein.	0.429
Dll1	Adam10	G3HNT7	G3GRM2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Disintegrin and metalloproteinase domain-containing protein 10.	0.698
Dll1	Jag1	G3HNT7	G3GSA7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.577
Dll1	Lfng	G3HNT7	G3GVF0	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Beta-1,3-N-acetylglucosaminyltransferase.	0.714
Dll1	Notch2	G3HNT7	G3HP78	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch-like protein 2.	0.978
Dll1	Psen1	G3HNT7	G3HNF2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.481
Dll1	Rbpj	G3HNT7	G3ICG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombining binding protein suppressor of hairless-like protein.	0.829
Jag1	Adam10	G3GSA7	G3GRM2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Disintegrin and metalloproteinase domain-containing protein 10.	0.553
Jag1	Dll1	G3GSA7	G3HNT7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.577
Jag1	Lfng	G3GSA7	G3GVF0	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Beta-1,3-N-acetylglucosaminyltransferase.	0.717
Jag1	Notch2	G3GSA7	G3HP78	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch-like protein 2.	0.981
Jag1	Psen1	G3GSA7	G3HNF2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.447
Jag1	Rbpj	G3GSA7	G3ICG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombining binding protein suppressor of hairless-like protein.	0.832
Lfng	Dll1	G3GVF0	G3HNT7	Beta-1,3-N-acetylglucosaminyltransferase.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.714
Lfng	Jag1	G3GVF0	G3GSA7	Beta-1,3-N-acetylglucosaminyltransferase.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.717