(23 nodes) (2020) Making radiation therapy more effective in the era of precision medicine. network (Cricetulus griseus)

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	Dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (741 aa)
	Notch2	Neurogenic locus notch-like protein 2. (1521 aa)
	CgPICR_018825	Cell division protein kinase 4. (121 aa)
	CgPICR_012539	Small ubiquitin-related modifier. (112 aa)
	I79_019128	Multidrug resistance protein 1. (438 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2527 aa)
	Mtor	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
	CgPICR_012325	Small ubiquitin-related modifier. (95 aa)
	I79_025861	Multidrug resistance protein 1. (151 aa)
	ABCB1	ATP-dependent translocase ABCB1; Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D- glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (1276 aa)
	Ccnd1	G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
	I79_001728	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (473 aa)
	I79_001729	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (436 aa)
	Smo	Smoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family. (984 aa)
	Kdm5b	Lysine-specific demethylase 5B. (748 aa)
	Lgr5	Leucine-rich repeat-containing G-protein coupled receptor 5. (555 aa)
	Aldh1a3	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (512 aa)
	Wrn	Werner syndrome ATP-dependent helicase-like. (1405 aa)
	Kdm5c	Lysine-specific demethylase 5C. (1551 aa)
	Sirt1	NAD-dependent deacetylase sirtuin-1. (554 aa)
	Spop	Speckle-type POZ protein. (374 aa)
	Brca1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1790 aa)
	Brca2	Breast cancer type 2 susceptibility protein-like. (3008 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Brca1	Brca2	G3HM05	G3HM86	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Breast cancer type 2 susceptibility protein-like.	0.999
Brca1	Ccnd1	G3HM05	A5A422	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.660
Brca1	CgPICR_012325	G3HM05	G3IH36	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Small ubiquitin-related modifier.	0.609
Brca1	CgPICR_012539	G3HM05	G3I572	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Small ubiquitin-related modifier.	0.587
Brca1	CgPICR_018825	G3HM05	G3HQ42	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Cell division protein kinase 4.	0.663
Brca1	Sirt1	G3HM05	G3HAB1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	NAD-dependent deacetylase sirtuin-1.	0.474
Brca1	Wrn	G3HM05	G3H625	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Werner syndrome ATP-dependent helicase-like.	0.971
Brca2	Brca1	G3HM86	G3HM05	Breast cancer type 2 susceptibility protein-like.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.999
Brca2	Ccnd1	G3HM86	A5A422	Breast cancer type 2 susceptibility protein-like.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.478
Brca2	CgPICR_018825	G3HM86	G3HQ42	Breast cancer type 2 susceptibility protein-like.	Cell division protein kinase 4.	0.572
Brca2	Wrn	G3HM86	G3H625	Breast cancer type 2 susceptibility protein-like.	Werner syndrome ATP-dependent helicase-like.	0.984
Ccnd1	Brca1	A5A422	G3HM05	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.660
Ccnd1	Brca2	A5A422	G3HM86	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Breast cancer type 2 susceptibility protein-like.	0.478
Ccnd1	CgPICR_018825	A5A422	G3HQ42	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Cell division protein kinase 4.	0.989
Ccnd1	Mtor	A5A422	G3IEE8	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.499
Ccnd1	NOTCH1	A5A422	G3I6Z6	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...]	0.635
Ccnd1	Sirt1	A5A422	G3HAB1	G1/S-specific cyclin-D1; Belongs to the cyclin family.	NAD-dependent deacetylase sirtuin-1.	0.514
CgPICR_012325	Brca1	G3IH36	G3HM05	Small ubiquitin-related modifier.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.609
CgPICR_012325	CgPICR_012539	G3IH36	G3I572	Small ubiquitin-related modifier.	Small ubiquitin-related modifier.	0.908
CgPICR_012325	Wrn	G3IH36	G3H625	Small ubiquitin-related modifier.	Werner syndrome ATP-dependent helicase-like.	0.727