(40 nodes) (2022) Host genetic diversity and genetic variations of SARS-CoV-2 in COVID-19 pathogenesis and the effectiveness of vaccination. network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Kdm5b	Lysine-specific demethylase 5B. (748 aa)
	Ifnar1	Interferon-alpha/beta receptor alpha chain. (483 aa)
	I79_001376	Von Willebrand factor. (3626 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)
	Zyg11b	Protein zyg-11-like B. (683 aa)
	Ezh2	Histone-lysine N-methyltransferase EZH2. (746 aa)
	Stxbp5	Syntaxin-binding protein 5. (1116 aa)
	Mbl2	Mannose-binding protein C. (250 aa)
	Eloc	Transcription elongation factor B polypeptide 1; Belongs to the SKP1 family. (112 aa)
	Il10	Interleukin-10. (178 aa)
	Il6r	Interleukin-6 receptor subunit alpha. (505 aa)
	Dpp9	Dipeptidyl peptidase 9; Belongs to the peptidase S9B family. (787 aa)
	Irf9	Interferon regulatory factor 9. (398 aa)
	I79_009287	Transmembrane protease, serine 2; Belongs to the peptidase S1 family. (412 aa)
	Rnasel	2-5A-dependent ribonuclease. (525 aa)
	Hdac2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (458 aa)
	Brd4	Bromodomain-containing protein 4. (723 aa)
	Brd2	Bromodomain-containing protein 2. (752 aa)
	Cul2	Cullin-2; Belongs to the cullin family. (745 aa)
	Ticam2	TIR domain-containing adapter molecule 2. (233 aa)
	Lztfl1	Leucine zipper transcription factor-like protein 1. (282 aa)
	Cxcr6	C-X-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (342 aa)
	CgPICR_014700	C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (373 aa)
	CgPICR_015959	Glutathione S-transferase theta-1; Belongs to the GST superfamily. (241 aa)
	I79_016618	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (470 aa)
	Cluap1	Clusterin-associated protein 1. (238 aa)
	Tlr4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	Isg15	Ubiquitin-like protein ISG15-like protein. (156 aa)
	Speg	Striated muscle preferentially expressed protein kinase. (152 aa)
	Tlr8	Toll-like receptor 8; Belongs to the Toll-like receptor family. (1027 aa)
	Tlr7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1033 aa)
	I79_021793	Interferon-induced transmembrane protein 3. (57 aa)
	H671_3g10394	Interferon-induced transmembrane protein 2. (95 aa)
	Slc39a10	Zinc transporter ZIP10. (791 aa)
	Cxcr3	C-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (286 aa)
	Elob	Transcription elongation factor B polypeptide 2. (267 aa)
	Gc	Vitamin D-binding protein. (492 aa)
	Tlr3	Toll-like receptor 3. (164 aa)
	Dpp7	Dipeptidyl-peptidase 2. (506 aa)
	fur	Furin endoprotease; Belongs to the peptidase S8 family. (794 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Brd2	Brd4	G3HQS5	G3HM62	Bromodomain-containing protein 2.	Bromodomain-containing protein 4.	0.655
Brd4	Brd2	G3HM62	G3HQS5	Bromodomain-containing protein 4.	Bromodomain-containing protein 2.	0.655
Brd4	Eloc	G3HM62	G3H9C9	Bromodomain-containing protein 4.	Transcription elongation factor B polypeptide 1; Belongs to the SKP1 family.	0.463
Cd4	CgPICR_014700	G3GUN9	G3HWU4	T-cell surface glycoprotein CD4.	C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family.	0.799
Cd4	Cxcr3	G3GUN9	G3IF30	T-cell surface glycoprotein CD4.	C-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family.	0.904
Cd4	Cxcr6	G3GUN9	G3HWT8	T-cell surface glycoprotein CD4.	C-X-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family.	0.788
Cd4	I79_001376	G3GUN9	G3GUL3	T-cell surface glycoprotein CD4.	Von Willebrand factor.	0.586
Cd4	I79_009287	G3GUN9	G3HFD1	T-cell surface glycoprotein CD4.	Transmembrane protease, serine 2; Belongs to the peptidase S1 family.	0.621
Cd4	I79_016618	G3GUN9	G3HZV4	T-cell surface glycoprotein CD4.	Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.	0.729
Cd4	I79_021793	G3GUN9	G3IDL0	T-cell surface glycoprotein CD4.	Interferon-induced transmembrane protein 3.	0.411
Cd4	Ifnar1	G3GUN9	G3GT51	T-cell surface glycoprotein CD4.	Interferon-alpha/beta receptor alpha chain.	0.771
Cd4	Il10	G3GUN9	G3HB01	T-cell surface glycoprotein CD4.	Interleukin-10.	0.968
Cd4	Il6r	G3GUN9	G3HBZ4	T-cell surface glycoprotein CD4.	Interleukin-6 receptor subunit alpha.	0.690
Cd4	Irf9	G3GUN9	G3HDE1	T-cell surface glycoprotein CD4.	Interferon regulatory factor 9.	0.407
Cd4	Isg15	G3GUN9	G3I436	T-cell surface glycoprotein CD4.	Ubiquitin-like protein ISG15-like protein.	0.771
Cd4	Mbl2	G3GUN9	G3H7W9	T-cell surface glycoprotein CD4.	Mannose-binding protein C.	0.729
Cd4	Rnasel	G3GUN9	G3HG31	T-cell surface glycoprotein CD4.	2-5A-dependent ribonuclease.	0.673
Cd4	Tlr3	G3GUN9	G3IHU2	T-cell surface glycoprotein CD4.	Toll-like receptor 3.	0.905
Cd4	Tlr4	G3GUN9	G3I192	T-cell surface glycoprotein CD4.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.914
Cd4	Tlr7	G3GUN9	G3I9Z2	T-cell surface glycoprotein CD4.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.912