STRINGSTRING
Tlr6 Tlr6 Cxcr2 Cxcr2 Tlr3 Tlr3 Csf1 Csf1 CgPICR_017379 CgPICR_017379 I79_022023 I79_022023 Hdac8 Hdac8 Enpp1 Enpp1 Tlr7 Tlr7 Stat1 Stat1 Ccr7 Ccr7 I79_017574 I79_017574 Cd80 Cd80 Tlr4 Tlr4 Tradd Tradd Hdac4 Hdac4 Pik3c3 Pik3c3 CgPICR_014700 CgPICR_014700 Stat6 Stat6 Ahr Ahr IL2 IL2 Myd88 Myd88 Hgf Hgf Hdac6 Hdac6 Foxp3 Foxp3 Stat3 Stat3 Hdac5 Hdac5 Syk Syk Hdac2 Hdac2 Cgas Cgas Gen1 Gen1 Ido1 Ido1 Tgfb3 Tgfb3 Elane Elane I79_008519 I79_008519 Cd47 Cd47 Muc1 Muc1 Il6r Il6r Msln Msln Il10 Il10 Cd86 Cd86 Hdac1 Hdac1 Mmp9 Mmp9 Cd40 Cd40 Crp Crp H671_1g1630 H671_1g1630 Il18 Il18 Tlr9 Tlr9 Ctla4 Ctla4 Cd68 Cd68 Ifng Ifng Cd163 Cd163 Cd4 Cd4 Irf8 Irf8 I79_000092 I79_000092 Tlr5 Tlr5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Tlr6Toll-like receptor. (795 aa)
Cxcr2High affinity interleukin-8 receptor B; Belongs to the G-protein coupled receptor 1 family. (359 aa)
Tlr3Toll-like receptor 3. (164 aa)
Csf1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (552 aa)
CgPICR_017379Toll-like receptor 11. (916 aa)
I79_022023Arginase-1; Belongs to the arginase family. (281 aa)
Hdac8Histone deacetylase 8. (257 aa)
Enpp1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (906 aa)
Tlr7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1033 aa)
Stat1Signal transducer and activator of transcription. (749 aa)
Ccr7C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
I79_017574Caspase-12; Belongs to the peptidase C14A family. (729 aa)
Cd80T-lymphocyte activation antigen CD80. (177 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
TraddTumor necrosis factor receptor type 1-associated DEATH domain protein. (306 aa)
Hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (966 aa)
Pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (822 aa)
CgPICR_014700C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (373 aa)
Stat6Signal transducer and activator of transcription. (844 aa)
AhrAryl hydrocarbon receptor. (247 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
Myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
HgfHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
Hdac6Histone deacetylase 6. (666 aa)
Foxp3Forkhead box protein P3. (428 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
Hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1081 aa)
SykTyrosine-protein kinase. (611 aa)
Hdac2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (458 aa)
CgasUncharacterized protein C6orf150. (512 aa)
Gen1Flap endonuclease GEN-like 1. (514 aa)
Ido1Indoleamine 2,3-dioxygenase 1. (567 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
ElaneNeutrophil elastase; Belongs to the peptidase S1 family. (252 aa)
I79_008519Natural killer cell protease 1; Belongs to the peptidase S1 family. (262 aa)
Cd47Leukocyte surface antigen CD47. (268 aa)
Muc1Mucin-1. (105 aa)
Il6rInterleukin-6 receptor subunit alpha. (505 aa)
MslnMesothelin. (335 aa)
Il10Interleukin-10. (178 aa)
Cd86T-lymphocyte activation antigen CD86. (269 aa)
Hdac1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
Mmp9Matrix metalloproteinase-9. (710 aa)
Cd40Tumor necrosis factor receptor superfamily member 5. (118 aa)
CrpPentaxin. (225 aa)
H671_1g1630Tryptophan 2,3-dioxygenase-like protein. (271 aa)
Il18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
Tlr9Toll-like receptor 9. (1239 aa)
Ctla4Cytotoxic T-lymphocyte protein 4. (171 aa)
Cd68Macrosialin. (294 aa)
IfngInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
Cd163Scavenger receptor cysteine-rich type 1 protein M130. (497 aa)
Cd4T-cell surface glycoprotein CD4. (447 aa)
Irf8Interferon regulatory factor 8. (424 aa)
I79_000092Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
Tlr5Toll-like receptor 5; Belongs to the Toll-like receptor family. (858 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.