(20 nodes) (2022) Influence of Foods and Nutrition on the Gut Microbiome and Implications for Intestinal Health. network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H671_xg20748	Angiotensin-converting enzyme. (644 aa)
	Gata3	Trans-acting T-cell-specific transcription factor GATA-3. (443 aa)
	I79_001019	Amino acid transporter. (596 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)
	Slc1a2	Amino acid transporter. (553 aa)
	Il18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
	Hdac1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
	Il10	Interleukin-10. (178 aa)
	I79_009669	Angiotensin-converting enzyme. (605 aa)
	Ace	Angiotensin-converting enzyme. (791 aa)
	I79_009671	Angiotensin-converting enzyme. (701 aa)
	Hdac2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (458 aa)
	Slc1a3	Amino acid transporter. (529 aa)
	Hdac5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1081 aa)
	Slc1a6	Amino acid transporter. (562 aa)
	Foxp3	Forkhead box protein P3. (428 aa)
	Slc1a1	Amino acid transporter. (492 aa)
	Ahr	Aryl hydrocarbon receptor. (247 aa)
	Hdac4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (966 aa)
	I79_018852	Amino acid transporter. (158 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ace	Cd4	G3HGE5	G3GUN9	Angiotensin-converting enzyme.	T-cell surface glycoprotein CD4.	0.577
Ace	H671_xg20748	G3HGE5	G3HH90	Angiotensin-converting enzyme.	Angiotensin-converting enzyme.	0.456
Ace	I79_001019	G3HGE5	G3GTN4	Angiotensin-converting enzyme.	Amino acid transporter.	0.410
Ace	I79_018852	G3HGE5	G3I5U4	Angiotensin-converting enzyme.	Amino acid transporter.	0.410
Ace	Il10	G3HGE5	G3HB01	Angiotensin-converting enzyme.	Interleukin-10.	0.440
Cd4	Ace	G3GUN9	G3HGE5	T-cell surface glycoprotein CD4.	Angiotensin-converting enzyme.	0.577
Cd4	Foxp3	G3GUN9	G3HNB1	T-cell surface glycoprotein CD4.	Forkhead box protein P3.	0.966
Cd4	Gata3	G3GUN9	G3GR59	T-cell surface glycoprotein CD4.	Trans-acting T-cell-specific transcription factor GATA-3.	0.885
Cd4	H671_xg20748	G3GUN9	G3HH90	T-cell surface glycoprotein CD4.	Angiotensin-converting enzyme.	0.762
Cd4	I79_009669	G3GUN9	G3HGE4	T-cell surface glycoprotein CD4.	Angiotensin-converting enzyme.	0.521
Cd4	I79_009671	G3GUN9	G3HGE6	T-cell surface glycoprotein CD4.	Angiotensin-converting enzyme.	0.521
Cd4	Il10	G3GUN9	G3HB01	T-cell surface glycoprotein CD4.	Interleukin-10.	0.968
Cd4	Il18	G3GUN9	G3H2H9	T-cell surface glycoprotein CD4.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.886
Foxp3	Cd4	G3HNB1	G3GUN9	Forkhead box protein P3.	T-cell surface glycoprotein CD4.	0.966
Foxp3	Gata3	G3HNB1	G3GR59	Forkhead box protein P3.	Trans-acting T-cell-specific transcription factor GATA-3.	0.814
Foxp3	Hdac1	G3HNB1	G3H942	Forkhead box protein P3.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.403
Foxp3	Il10	G3HNB1	G3HB01	Forkhead box protein P3.	Interleukin-10.	0.921
Foxp3	Il18	G3HNB1	G3H2H9	Forkhead box protein P3.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.499
Gata3	Cd4	G3GR59	G3GUN9	Trans-acting T-cell-specific transcription factor GATA-3.	T-cell surface glycoprotein CD4.	0.885
Gata3	Foxp3	G3GR59	G3HNB1	Trans-acting T-cell-specific transcription factor GATA-3.	Forkhead box protein P3.	0.814