STRINGSTRING
Tlr6 Tlr6 CgPICR_017379 CgPICR_017379 Jak2 Jak2 I79_021949 I79_021949 Tlr7 Tlr7 I79_020089 I79_020089 I79_018057 I79_018057 Tlr4 Tlr4 PPARG PPARG IL2 IL2 Foxp3 Foxp3 Stat3 Stat3 Ccna1 Ccna1 Bcl2 Bcl2 Il10 Il10 Sirt1 Sirt1 Mmp9 Mmp9 Kras Kras I79_004417 I79_004417 Nfe2l2 Nfe2l2 Ifng Ifng I79_001600 I79_001600 Cd4 Cd4 Gata3 Gata3 Ccnd1 Ccnd1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Tlr6Toll-like receptor. (795 aa)
CgPICR_017379Toll-like receptor 11. (916 aa)
Jak2Tyrosine-protein kinase. (1122 aa)
I79_021949Caspase-3; Belongs to the peptidase C14A family. (195 aa)
Tlr7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1033 aa)
I79_020089Caspase-9; Belongs to the peptidase C14A family. (689 aa)
I79_018057Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
Foxp3Forkhead box protein P3. (428 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
Ccna1Cyclin-A1; Belongs to the cyclin family. (351 aa)
Bcl2Apoptosis regulator Bcl-2. (203 aa)
Il10Interleukin-10. (178 aa)
Sirt1NAD-dependent deacetylase sirtuin-1. (554 aa)
Mmp9Matrix metalloproteinase-9. (710 aa)
KrasGTPase KRas. (155 aa)
I79_004417Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Nfe2l2Nuclear factor erythroid 2-related factor 2. (588 aa)
IfngInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
I79_001600Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
Cd4T-cell surface glycoprotein CD4. (447 aa)
Gata3Trans-acting T-cell-specific transcription factor GATA-3. (443 aa)
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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