STRINGSTRING
Casp8 Casp8 CgPICR_008588 CgPICR_008588 I79_021949 I79_021949 CgPICR_012401 CgPICR_012401 Nox4 Nox4 I79_018057 I79_018057 CgPICR_017546 CgPICR_017546 Tnf Tnf CgPICR_002995 CgPICR_002995 Itgb1 Itgb1 CgPICR_017739 CgPICR_017739 Sod2 Sod2 Fadd Fadd CgPICR_013910 CgPICR_013910 Stat3 Stat3 CgPICR_000709 CgPICR_000709 CgPICR_000710 CgPICR_000710 CgPICR_020194 CgPICR_020194 CgPICR_002764 CgPICR_002764 Bcl2 Bcl2 Prkca Prkca Smad2 Smad2 Sirt1 Sirt1 I79_004417 I79_004417 Mmp2 Mmp2 I79_001600 I79_001600
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Casp8Caspase-8; Belongs to the peptidase C14A family. (481 aa)
CgPICR_008588Glyceraldehyde-3-phosphate dehydrogenase. (161 aa)
I79_021949Caspase-3; Belongs to the peptidase C14A family. (195 aa)
CgPICR_012401Glyceraldehyde-3-phosphate dehydrogenase. (75 aa)
Nox4NADPH oxidase 4. (130 aa)
I79_018057Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
CgPICR_017546Glyceraldehyde-3-phosphate dehydrogenase. (127 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
CgPICR_002995Glyceraldehyde-3-phosphate dehydrogenase. (206 aa)
Itgb1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
CgPICR_017739Glyceraldehyde-3-phosphate dehydrogenase. (163 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
FaddFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
CgPICR_013910Glyceraldehyde-3-phosphate dehydrogenase. (104 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
CgPICR_000709Glyceraldehyde-3-phosphate dehydrogenase. (148 aa)
CgPICR_000710Glyceraldehyde-3-phosphate dehydrogenase. (129 aa)
CgPICR_020194Glyceraldehyde-3-phosphate dehydrogenase. (105 aa)
CgPICR_002764Glyceraldehyde-3-phosphate dehydrogenase. (77 aa)
Bcl2Apoptosis regulator Bcl-2. (203 aa)
PrkcaNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (487 aa)
Smad2Mothers against decapentaplegic homolog. (467 aa)
Sirt1NAD-dependent deacetylase sirtuin-1. (554 aa)
I79_004417Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Mmp272 kDa type IV collagenase. (662 aa)
I79_001600Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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