STRINGSTRING
I79_007693 I79_007693 Sirt1 Sirt1 I79_007329 I79_007329 Ccnd1 Ccnd1 I79_000801 I79_000801 Lyrm9 Lyrm9 Esr1 Esr1 Nos1 Nos1 I79_001600 I79_001600 Src Src I79_006924 I79_006924 I79_006923 I79_006923 Hdac1 Hdac1 Hkdc1 Hkdc1 Hk1 Hk1 Hk3 Hk3 I79_004417 I79_004417 Mcl1 Mcl1 Pcna Pcna Hk2 Hk2 I79_021949 I79_021949 Keap1 Keap1 Gpt2 Gpt2 I79_018057 I79_018057 IL1B IL1B Ins Ins Gpt Gpt Sod2 Sod2 Stat3 Stat3 CgPICR_013689 CgPICR_013689 Bcl2 Bcl2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I79_007693Nitric oxide synthase; Produces nitric oxide (NO). (1129 aa)
Sirt1NAD-dependent deacetylase sirtuin-1. (554 aa)
I79_007329Histone deacetylase 1. (250 aa)
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
I79_000801Histone deacetylase 1. (92 aa)
Lyrm9Nitric oxide synthase; Produces nitric oxide (NO); Belongs to the complex I LYR family. (1115 aa)
Esr1Estrogen receptor. (200 aa)
Nos1Nitric oxide synthase; Produces nitric oxide (NO). (1413 aa)
I79_001600Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
SrcTyrosine-protein kinase. (536 aa)
I79_006924Histone deacetylase 1. (188 aa)
I79_006923Histone deacetylase 1. (235 aa)
Hdac1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
Hkdc1Putative hexokinase HKDC1. (925 aa)
Hk1Hexokinase-1. (917 aa)
Hk3Hexokinase-3. (867 aa)
I79_004417Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Mcl1Putative induced myeloid leukemia cell differentiation protein Mcl-1 like protein. (120 aa)
PcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
Hk2Hexokinase-2. (704 aa)
I79_021949Caspase-3; Belongs to the peptidase C14A family. (195 aa)
Keap1Kelch-like ECH-associated protein 1. (624 aa)
Gpt2Alanine aminotransferase 2. (470 aa)
I79_018057Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
InsMultifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
GptAlanine aminotransferase 1. (481 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
CgPICR_013689Cytochrome P450 1A1; Belongs to the cytochrome P450 family. (522 aa)
Bcl2Apoptosis regulator Bcl-2. (203 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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