STRINGSTRING
I79_020288 I79_020288 I79_025220 I79_025220 Hk2 Hk2 Rxra Rxra Gusb Gusb Lyrm9 Lyrm9 Nos1 Nos1 Cd4 Cd4 Cry2 Cry2 Nr1h3 Nr1h3 Got1 Got1 Hk3 Hk3 Myog Myog Hk1 Hk1 Hkdc1 Hkdc1 Gsk3b Gsk3b I79_007693 I79_007693 Bglap Bglap Sema4a Sema4a Ogdh Ogdh Cry1 Cry1 Hmox2 Hmox2 I79_013712 I79_013712 PPARG PPARG Sod2 Sod2 Ins Ins Nfil3 Nfil3 Adipoq Adipoq CgPICR_005625 CgPICR_005625 Tlr4 Tlr4 Per2 Per2 Got2 Got2 Cxcl1 Cxcl1 Bche Bche Nr5a1 Nr5a1 Hmox1 Hmox1 Alb Alb I79_021577 I79_021577
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I79_020288Cytosolic beta-glucosidase; Belongs to the glycosyl hydrolase 1 family. (317 aa)
I79_025220Serum albumin. (186 aa)
Hk2Hexokinase-2. (704 aa)
RxraRetinoic acid receptor RXR-alpha. (439 aa)
GusbBeta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (648 aa)
Lyrm9Nitric oxide synthase; Produces nitric oxide (NO); Belongs to the complex I LYR family. (1115 aa)
Nos1Nitric oxide synthase; Produces nitric oxide (NO). (1413 aa)
Cd4T-cell surface glycoprotein CD4. (447 aa)
Cry2Cryptochrome-2. (577 aa)
Nr1h3Oxysterols receptor LXR-alpha. (402 aa)
Got1Aspartate aminotransferase. (413 aa)
Hk3Hexokinase-3. (867 aa)
MyogMyogenin. (224 aa)
Hk1Hexokinase-1. (917 aa)
Hkdc1Putative hexokinase HKDC1. (925 aa)
Gsk3bGlycogen synthase kinase-3 beta. (328 aa)
I79_007693Nitric oxide synthase; Produces nitric oxide (NO). (1129 aa)
BglapOsteocalcin; Binds strongly to apatite and calcium. (99 aa)
Sema4aSemaphorin-4A; Belongs to the semaphorin family. (761 aa)
Ogdh2-oxoglutarate dehydrogenase E1 component, mitochondrial. (917 aa)
Cry1Cryptochrome-1. (428 aa)
Hmox2Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (316 aa)
I79_013712Suppressor of cytokine signaling 2. (198 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
InsMultifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
Nfil3Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...] (457 aa)
AdipoqAdiponectin. (248 aa)
CgPICR_005625Agouti-related protein. (131 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
Per2Period circadian protein-like 2. (1262 aa)
Got2Aspartate aminotransferase. (430 aa)
Cxcl1C-X-C motif chemokine. (101 aa)
BcheCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (507 aa)
Nr5a1Steroidogenic factor 1. (462 aa)
Hmox1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (290 aa)
AlbSerum albumin. (430 aa)
I79_021577Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (248 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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