(10 nodes) (2023) Comparison of protective effects of hesperetin and pectolinarigenin on high-fat diet-induced hyperlipidemia and hepatic steatosis in Golden Syrian hamsters. network (Cricetulus griseus)

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Your Input:
	I79_022390	Peroxisome proliferator-activated receptor alpha. (110 aa)
	I79_025220	Serum albumin. (186 aa)
	LDLR	Low-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits; Belongs to the LDLR family. (862 aa)
	Fasn	Fatty acid synthase. (2503 aa)
	Apob	Apolipoprotein B-100. (3537 aa)
	I79_006999	Acetyl-CoA carboxylase 1. (1579 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
	Alb	Serum albumin. (430 aa)
	I79_021198	Acetyl-CoA carboxylase 1. (231 aa)
	Ppara	Peroxisome proliferator-activated receptor alpha. (393 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Alb	Apob	G3IAL6	G3GZQ0	Serum albumin.	Apolipoprotein B-100.	0.657
Alb	I79_025220	G3IAL6	G3IMS5	Serum albumin.	Serum albumin.	0.960
Alb	PPARG	G3IAL6	G3HVG0	Serum albumin.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.443
Apob	Alb	G3GZQ0	G3IAL6	Apolipoprotein B-100.	Serum albumin.	0.657
Apob	Fasn	G3GZQ0	G3GXD7	Apolipoprotein B-100.	Fatty acid synthase.	0.485
Apob	I79_022390	G3GZQ0	G3IF74	Apolipoprotein B-100.	Peroxisome proliferator-activated receptor alpha.	0.505
Apob	I79_025220	G3GZQ0	G3IMS5	Apolipoprotein B-100.	Serum albumin.	0.657
Apob	LDLR	G3GZQ0	P35950	Apolipoprotein B-100.	Low-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits; Belongs to the LDLR family.	0.958
Apob	PPARG	G3GZQ0	G3HVG0	Apolipoprotein B-100.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.584
Apob	Ppara	G3GZQ0	G3IF76	Apolipoprotein B-100.	Peroxisome proliferator-activated receptor alpha.	0.509
Fasn	Apob	G3GXD7	G3GZQ0	Fatty acid synthase.	Apolipoprotein B-100.	0.485
Fasn	I79_006999	G3GXD7	G3H9D1	Fatty acid synthase.	Acetyl-CoA carboxylase 1.	0.823
Fasn	I79_021198	G3GXD7	G3IC10	Fatty acid synthase.	Acetyl-CoA carboxylase 1.	0.823
Fasn	I79_022390	G3GXD7	G3IF74	Fatty acid synthase.	Peroxisome proliferator-activated receptor alpha.	0.404
Fasn	PPARG	G3GXD7	G3HVG0	Fatty acid synthase.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.756
Fasn	Ppara	G3GXD7	G3IF76	Fatty acid synthase.	Peroxisome proliferator-activated receptor alpha.	0.535
I79_006999	Fasn	G3H9D1	G3GXD7	Acetyl-CoA carboxylase 1.	Fatty acid synthase.	0.823
I79_006999	I79_021198	G3H9D1	G3IC10	Acetyl-CoA carboxylase 1.	Acetyl-CoA carboxylase 1.	0.927
I79_006999	I79_022390	G3H9D1	G3IF74	Acetyl-CoA carboxylase 1.	Peroxisome proliferator-activated receptor alpha.	0.545
I79_006999	PPARG	G3H9D1	G3HVG0	Acetyl-CoA carboxylase 1.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.409