(37 nodes) (2022) Filoviruses: Innate Immunity, Inflammatory Cell Death, and Cytokines. network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Bcl2	Apoptosis regulator Bcl-2. (203 aa)
	Il10	Interleukin-10. (178 aa)
	Mavs	Mitochondrial antiviral-signaling protein. (505 aa)
	I79_004417	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	Il18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
	Ctsb	Cathepsin B; Belongs to the peptidase C1 family. (339 aa)
	Traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (508 aa)
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	Irak2	Interleukin-1 receptor-associated kinase-like 2. (626 aa)
	I79_001600	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
	Ifnar1	Interferon-alpha/beta receptor alpha chain. (483 aa)
	Casp8	Caspase-8; Belongs to the peptidase C14A family. (481 aa)
	I79_025440	Cathepsin L1; Belongs to the peptidase C1 family. (333 aa)
	Casp7	Caspase-7. (303 aa)
	Tlr3	Toll-like receptor 3. (164 aa)
	Ripk1	Receptor-interacting serine/threonine-protein kinase 1. (655 aa)
	I79_021949	Caspase-3; Belongs to the peptidase C14A family. (195 aa)
	Irak4	Interleukin-1 receptor-associated kinase 4. (462 aa)
	Stat1	Signal transducer and activator of transcription. (749 aa)
	I79_020089	Caspase-9; Belongs to the peptidase C14A family. (689 aa)
	I79_019922	Serine/threonine-protein kinase TBK1. (421 aa)
	I79_019425	Apoptosis-associated speck-like protein containing a CARD. (192 aa)
	Gsdmd	Gasdermin-D. (486 aa)
	I79_018057	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
	Mlkl	Mixed lineage kinase domain-like protein. (484 aa)
	I79_017574	Caspase-12; Belongs to the peptidase C14A family. (729 aa)
	Tlr4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	H671_7g18521	Pyrin-like protein. (685 aa)
	Tradd	Tumor necrosis factor receptor type 1-associated DEATH domain protein. (306 aa)
	Jak1	Tyrosine-protein kinase. (1140 aa)
	Mex3c	RNA-binding protein MEX3C. (358 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
	Irak1	Interleukin-1 receptor-associated kinase 1. (494 aa)
	Myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	Fadd	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	Nlrc4	NLR family CARD domain-containing protein 4. (857 aa)
	Irf9	Interferon regulatory factor 9. (398 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bcl2	Casp7	G3HD46	G3IL63	Apoptosis regulator Bcl-2.	Caspase-7.	0.713
Bcl2	Casp8	G3HD46	B2CMK5	Apoptosis regulator Bcl-2.	Caspase-8; Belongs to the peptidase C14A family.	0.860
Bcl2	Ctsb	G3HD46	G3H0L9	Apoptosis regulator Bcl-2.	Cathepsin B; Belongs to the peptidase C1 family.	0.919
Bcl2	Fadd	G3HD46	G3HQ71	Apoptosis regulator Bcl-2.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.538
Bcl2	I79_001600	G3HD46	G3GV69	Apoptosis regulator Bcl-2.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.993
Bcl2	I79_004417	G3HD46	G3H2K2	Apoptosis regulator Bcl-2.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.994
Bcl2	I79_017574	G3HD46	G3I2E4	Apoptosis regulator Bcl-2.	Caspase-12; Belongs to the peptidase C14A family.	0.636
Bcl2	I79_018057	G3HD46	G3I3P7	Apoptosis regulator Bcl-2.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.994
Bcl2	I79_020089	G3HD46	G3I954	Apoptosis regulator Bcl-2.	Caspase-9; Belongs to the peptidase C14A family.	0.970
Bcl2	I79_021949	G3HD46	G3IE08	Apoptosis regulator Bcl-2.	Caspase-3; Belongs to the peptidase C14A family.	0.938
Bcl2	I79_025440	G3HD46	G3INC5	Apoptosis regulator Bcl-2.	Cathepsin L1; Belongs to the peptidase C1 family.	0.901
Bcl2	IL2	G3HD46	G3HTL8	Apoptosis regulator Bcl-2.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.467
Bcl2	Ifng	G3HD46	G3GY20	Apoptosis regulator Bcl-2.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.478
Bcl2	Il10	G3HD46	G3HB01	Apoptosis regulator Bcl-2.	Interleukin-10.	0.500
Bcl2	Stat1	G3HD46	G3I9F9	Apoptosis regulator Bcl-2.	Signal transducer and activator of transcription.	0.474
Casp7	Bcl2	G3IL63	G3HD46	Caspase-7.	Apoptosis regulator Bcl-2.	0.713
Casp7	Casp8	G3IL63	B2CMK5	Caspase-7.	Caspase-8; Belongs to the peptidase C14A family.	0.968
Casp7	Fadd	G3IL63	G3HQ71	Caspase-7.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.640
Casp7	Gsdmd	G3IL63	G3I5H6	Caspase-7.	Gasdermin-D.	0.631
Casp7	I79_001600	G3IL63	G3GV69	Caspase-7.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.769