(11 nodes) (2023) Recent advances in respiratory immunization: A focus on COVID-19 vaccines. network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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protein homology

Your Input:
	Cd4	T-cell surface glycoprotein CD4. (447 aa)
	fur	Furin endoprotease; Belongs to the peptidase S8 family. (794 aa)
	Tlr3	Toll-like receptor 3. (164 aa)
	Tlr7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1033 aa)
	Tlr4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	Il15	Interleukin; Belongs to the IL-15/IL-21 family. (155 aa)
	Piga	N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein. (485 aa)
	Il10	Interleukin-10. (178 aa)
	Mavs	Mitochondrial antiviral-signaling protein. (505 aa)
	Il18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
	Tlr5	Toll-like receptor 5; Belongs to the Toll-like receptor family. (858 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cd4	Il10	G3GUN9	G3HB01	T-cell surface glycoprotein CD4.	Interleukin-10.	0.968
Cd4	Il15	G3GUN9	G3HJ60	T-cell surface glycoprotein CD4.	Interleukin; Belongs to the IL-15/IL-21 family.	0.915
Cd4	Il18	G3GUN9	G3H2H9	T-cell surface glycoprotein CD4.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.886
Cd4	Mavs	G3GUN9	G3H421	T-cell surface glycoprotein CD4.	Mitochondrial antiviral-signaling protein.	0.489
Cd4	Tlr3	G3GUN9	G3IHU2	T-cell surface glycoprotein CD4.	Toll-like receptor 3.	0.905
Cd4	Tlr4	G3GUN9	G3I192	T-cell surface glycoprotein CD4.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.914
Cd4	Tlr5	G3GUN9	G3GRB7	T-cell surface glycoprotein CD4.	Toll-like receptor 5; Belongs to the Toll-like receptor family.	0.784
Cd4	Tlr7	G3GUN9	G3I9Z2	T-cell surface glycoprotein CD4.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.912
Cd4	fur	G3GUN9	Q60426	T-cell surface glycoprotein CD4.	Furin endoprotease; Belongs to the peptidase S8 family.	0.866
Il10	Cd4	G3HB01	G3GUN9	Interleukin-10.	T-cell surface glycoprotein CD4.	0.968
Il10	Il15	G3HB01	G3HJ60	Interleukin-10.	Interleukin; Belongs to the IL-15/IL-21 family.	0.905
Il10	Il18	G3HB01	G3H2H9	Interleukin-10.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.909
Il10	Tlr3	G3HB01	G3IHU2	Interleukin-10.	Toll-like receptor 3.	0.757
Il10	Tlr4	G3HB01	G3I192	Interleukin-10.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.942
Il10	Tlr5	G3HB01	G3GRB7	Interleukin-10.	Toll-like receptor 5; Belongs to the Toll-like receptor family.	0.673
Il10	Tlr7	G3HB01	G3I9Z2	Interleukin-10.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.708
Il10	fur	G3HB01	Q60426	Interleukin-10.	Furin endoprotease; Belongs to the peptidase S8 family.	0.444
Il15	Cd4	G3HJ60	G3GUN9	Interleukin; Belongs to the IL-15/IL-21 family.	T-cell surface glycoprotein CD4.	0.915
Il15	Il10	G3HJ60	G3HB01	Interleukin; Belongs to the IL-15/IL-21 family.	Interleukin-10.	0.905
Il15	Il18	G3HJ60	G3H2H9	Interleukin; Belongs to the IL-15/IL-21 family.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.827