(32 nodes) (2023) The Complexity of Interferon Signaling in Host Defense against Protozoan Parasite Infection. network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	Stat1	Signal transducer and activator of transcription. (749 aa)
	Tlr4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	Lta	Lymphotoxin-alpha; Belongs to the tumor necrosis factor family. (202 aa)
	Tnf	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
	Jak1	Tyrosine-protein kinase. (1140 aa)
	I79_015333	Natural resistance-associated macrophage protein 1. (436 aa)
	Atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (147 aa)
	Stat2	Signal transducer and activator of transcription. (806 aa)
	Myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	Ido1	Indoleamine 2,3-dioxygenase 1. (567 aa)
	Ido2	Indoleamine 2,3-dioxygenase 2. (280 aa)
	Irf9	Interferon regulatory factor 9. (398 aa)
	Il10	Interleukin-10. (178 aa)
	Mavs	Mitochondrial antiviral-signaling protein. (505 aa)
	Il18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
	Pfn4	Profilin-4; Belongs to the profilin family. (110 aa)
	Tlr9	Toll-like receptor 9. (1239 aa)
	Traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (508 aa)
	Pfn1	Profilin-1; Belongs to the profilin family. (55 aa)
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	Ifngr1	Interferon-gamma receptor alpha chain. (471 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)
	Ifnar1	Interferon-alpha/beta receptor alpha chain. (483 aa)
	I79_000639	Circumsporozoite protein. (113 aa)
	ICAM1	Intercellular adhesion molecule 1. (527 aa)
	Trim21	52 kDa Ro protein. (463 aa)
	Tlr3	Toll-like receptor 3. (164 aa)
	Gbp5	Guanylate-binding protein 5. (182 aa)
	Jak2	Tyrosine-protein kinase. (1122 aa)
	Vcam1	Vascular cell adhesion protein 1. (220 aa)
	CgPICR_018843	Profilin; Belongs to the profilin family. (153 aa)
	Pfn2	Profilin; Belongs to the profilin family. (91 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atg5	Cd4	G3HVR2	G3GUN9	Autophagy protein 5; Involved in autophagic vesicle formation.	T-cell surface glycoprotein CD4.	0.564
Atg5	Mavs	G3HVR2	G3H421	Autophagy protein 5; Involved in autophagic vesicle formation.	Mitochondrial antiviral-signaling protein.	0.947
Atg5	Stat1	G3HVR2	G3I9F9	Autophagy protein 5; Involved in autophagic vesicle formation.	Signal transducer and activator of transcription.	0.448
Atg5	Traf6	G3HVR2	G3GZ05	Autophagy protein 5; Involved in autophagic vesicle formation.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.467
Cd4	Atg5	G3GUN9	G3HVR2	T-cell surface glycoprotein CD4.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.564
Cd4	ICAM1	G3GUN9	Q9ERF7	T-cell surface glycoprotein CD4.	Intercellular adhesion molecule 1.	0.864
Cd4	Ido1	G3GUN9	G3HGG2	T-cell surface glycoprotein CD4.	Indoleamine 2,3-dioxygenase 1.	0.798
Cd4	Ido2	G3GUN9	G3HGG1	T-cell surface glycoprotein CD4.	Indoleamine 2,3-dioxygenase 2.	0.795
Cd4	Ifnar1	G3GUN9	G3GT51	T-cell surface glycoprotein CD4.	Interferon-alpha/beta receptor alpha chain.	0.771
Cd4	Ifng	G3GUN9	G3GY20	T-cell surface glycoprotein CD4.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.966
Cd4	Ifngr1	G3GUN9	G3GW63	T-cell surface glycoprotein CD4.	Interferon-gamma receptor alpha chain.	0.587
Cd4	Il10	G3GUN9	G3HB01	T-cell surface glycoprotein CD4.	Interleukin-10.	0.968
Cd4	Il18	G3GUN9	G3H2H9	T-cell surface glycoprotein CD4.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.886
Cd4	Irf9	G3GUN9	G3HDE1	T-cell surface glycoprotein CD4.	Interferon regulatory factor 9.	0.407
Cd4	Jak1	G3GUN9	G3HY52	T-cell surface glycoprotein CD4.	Tyrosine-protein kinase.	0.800
Cd4	Jak2	G3GUN9	G3IEQ4	T-cell surface glycoprotein CD4.	Tyrosine-protein kinase.	0.745
Cd4	Lta	G3GUN9	G3HZH0	T-cell surface glycoprotein CD4.	Lymphotoxin-alpha; Belongs to the tumor necrosis factor family.	0.749
Cd4	Mavs	G3GUN9	G3H421	T-cell surface glycoprotein CD4.	Mitochondrial antiviral-signaling protein.	0.489
Cd4	Myd88	G3GUN9	G3HQV3	T-cell surface glycoprotein CD4.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.879
Cd4	Stat1	G3GUN9	G3I9F9	T-cell surface glycoprotein CD4.	Signal transducer and activator of transcription.	0.893