(18 nodes) (2023) Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells. network (Cricetulus griseus)

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Your Input:
	CgPICR_012401	Glyceraldehyde-3-phosphate dehydrogenase. (75 aa)
	Topbp1	DNA topoisomerase II-binding protein 1. (1517 aa)
	Cip2a	Protein CIP2A. (588 aa)
	Ccna1	Cyclin-A1; Belongs to the cyclin family. (351 aa)
	CgPICR_002764	Glyceraldehyde-3-phosphate dehydrogenase. (77 aa)
	CgPICR_020194	Glyceraldehyde-3-phosphate dehydrogenase. (105 aa)
	CgPICR_000710	Glyceraldehyde-3-phosphate dehydrogenase. (129 aa)
	CgPICR_000709	Glyceraldehyde-3-phosphate dehydrogenase. (148 aa)
	Brca1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1790 aa)
	Brca2	Breast cancer type 2 susceptibility protein-like. (3008 aa)
	CgPICR_013910	Glyceraldehyde-3-phosphate dehydrogenase. (104 aa)
	Cdk1	Cell division control protein 2-like; Belongs to the protein kinase superfamily. (297 aa)
	CgPICR_017739	Glyceraldehyde-3-phosphate dehydrogenase. (163 aa)
	CgPICR_002995	Glyceraldehyde-3-phosphate dehydrogenase. (206 aa)
	CgPICR_017546	Glyceraldehyde-3-phosphate dehydrogenase. (127 aa)
	I79_020971	Nucleophosmin. (280 aa)
	CgPICR_008588	Glyceraldehyde-3-phosphate dehydrogenase. (161 aa)
	Plk1	Serine/threonine-protein kinase PLK. (602 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Brca1	Brca2	G3HM05	G3HM86	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Breast cancer type 2 susceptibility protein-like.	0.999
Brca1	Ccna1	G3HM05	G3HGB6	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Cyclin-A1; Belongs to the cyclin family.	0.650
Brca1	Cdk1	G3HM05	G3HVL1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	0.724
Brca1	Plk1	G3HM05	G3IN30	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Serine/threonine-protein kinase PLK.	0.781
Brca1	Topbp1	G3HM05	G3GZG7	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA topoisomerase II-binding protein 1.	0.983
Brca2	Brca1	G3HM86	G3HM05	Breast cancer type 2 susceptibility protein-like.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.999
Brca2	Ccna1	G3HM86	G3HGB6	Breast cancer type 2 susceptibility protein-like.	Cyclin-A1; Belongs to the cyclin family.	0.496
Brca2	Cdk1	G3HM86	G3HVL1	Breast cancer type 2 susceptibility protein-like.	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	0.599
Brca2	Plk1	G3HM86	G3IN30	Breast cancer type 2 susceptibility protein-like.	Serine/threonine-protein kinase PLK.	0.896
Brca2	Topbp1	G3HM86	G3GZG7	Breast cancer type 2 susceptibility protein-like.	DNA topoisomerase II-binding protein 1.	0.598
Ccna1	Brca1	G3HGB6	G3HM05	Cyclin-A1; Belongs to the cyclin family.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.650
Ccna1	Brca2	G3HGB6	G3HM86	Cyclin-A1; Belongs to the cyclin family.	Breast cancer type 2 susceptibility protein-like.	0.496
Ccna1	Cdk1	G3HGB6	G3HVL1	Cyclin-A1; Belongs to the cyclin family.	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	0.998
Ccna1	Plk1	G3HGB6	G3IN30	Cyclin-A1; Belongs to the cyclin family.	Serine/threonine-protein kinase PLK.	0.853
Cdk1	Brca1	G3HVL1	G3HM05	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.724
Cdk1	Brca2	G3HVL1	G3HM86	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	Breast cancer type 2 susceptibility protein-like.	0.599
Cdk1	Ccna1	G3HVL1	G3HGB6	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	Cyclin-A1; Belongs to the cyclin family.	0.998
Cdk1	Cip2a	G3HVL1	G3H7C7	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	Protein CIP2A.	0.423
Cdk1	Plk1	G3HVL1	G3IN30	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase PLK.	0.999
Cdk1	Topbp1	G3HVL1	G3GZG7	Cell division control protein 2-like; Belongs to the protein kinase superfamily.	DNA topoisomerase II-binding protein 1.	0.466