STRINGSTRING
Lep Lep Cry2 Cry2 I79_002536 I79_002536 Hdac5 Hdac5 Cry1 Cry1 Adcy2 Adcy2 PPARG PPARG Ins Ins Nr3c1 Nr3c1 Adcy4 Adcy4 I79_015980 I79_015980 Hdac4 Hdac4 CgPICR_005625 CgPICR_005625 Dbp Dbp Per2 Per2 Adcy6 Adcy6 Clock Clock Cck Cck Hdac2 Hdac2 Ghrl Ghrl Hdac1 Hdac1 Npy Npy
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Cry2Cryptochrome-2. (577 aa)
I79_002536Pro-opiomelanocortin. (159 aa)
Hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1081 aa)
Cry1Cryptochrome-1. (428 aa)
Adcy2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (999 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
InsMultifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
Nr3c1Glucocorticoid receptor. (748 aa)
Adcy4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1022 aa)
I79_015980Leptin receptor. (533 aa)
Hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (966 aa)
CgPICR_005625Agouti-related protein. (131 aa)
DbpD site-binding protein. (123 aa)
Per2Period circadian protein-like 2. (1262 aa)
Adcy6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
ClockCircadian locomoter output cycles protein kaput. (599 aa)
CckCholecystokinin. (115 aa)
Hdac2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (458 aa)
GhrlAppetite-regulating hormone. (100 aa)
Hdac1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
NpyNeuropeptide Y. (148 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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