STRINGSTRING
Gpx5 Gpx5 Myd88 Myd88 PPARG PPARG I79_015041 I79_015041 Sod2 Sod2 Pik3c3 Pik3c3 Ins Ins Adipoq Adipoq I79_016240 I79_016240 Nqo1 Nqo1 I79_018057 I79_018057 I79_020089 I79_020089 Stat1 Stat1 Gpx8 Gpx8 I79_021949 I79_021949 Bnip3 Bnip3 Tyms Tyms Ache Ache I79_001600 I79_001600 Gpx7 Gpx7 Ifng Ifng Prdx1 Prdx1 Lep Lep I79_004417 I79_004417 Socs3 Socs3 Gpx3 Gpx3 Tyk2 Tyk2 Gpx1 Gpx1 Il10 Il10 Bcl2 Bcl2 I79_009215 I79_009215 Stat3 Stat3 Becn1 Becn1 Gpx6 Gpx6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Gpx5Glutathione peroxidase; Belongs to the glutathione peroxidase family. (192 aa)
Myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
I79_015041Thymidylate synthase. (192 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
Pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (822 aa)
InsMultifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
AdipoqAdiponectin. (248 aa)
I79_016240Beclin-1. (119 aa)
Nqo1NAD(P)H dehydrogenase [quinone] 1. (274 aa)
I79_018057Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
I79_020089Caspase-9; Belongs to the peptidase C14A family. (689 aa)
Stat1Signal transducer and activator of transcription. (749 aa)
Gpx8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
I79_021949Caspase-3; Belongs to the peptidase C14A family. (195 aa)
Bnip3BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (151 aa)
TymsThymidylate synthase-like protein. (307 aa)
AcheCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (575 aa)
I79_001600Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
Gpx7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
IfngInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
Prdx1Peroxiredoxin-1. (199 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
I79_004417Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Socs3Suppressor of cytokine signaling 3. (225 aa)
Gpx3Glutathione peroxidase 3. (53 aa)
Tyk2Tyrosine-protein kinase. (1182 aa)
Gpx1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (145 aa)
Il10Interleukin-10. (178 aa)
Bcl2Apoptosis regulator Bcl-2. (203 aa)
I79_009215Glutathione peroxidase; Belongs to the glutathione peroxidase family. (199 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
Becn1Beclin-1. (448 aa)
Gpx6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (221 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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