(42 nodes) (2023) CRISPR Technologies in Chinese Hamster Ovary Cell Line Engineering. network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Anxa2	Annexin. (244 aa)
	Mtor	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
	Stat1	Signal transducer and activator of transcription. (749 aa)
	B4galt1	Beta-1,4-galactosyltransferase 1. (258 aa)
	Epo	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
	Ctsd	Cathepsin D; Belongs to the peptidase A1 family. (408 aa)
	St3gal6	Type 2 lactosamine alpha-2,3-sialyltransferase; Belongs to the glycosyltransferase 29 family. (320 aa)
	B4galt4	Beta-1,4-galactosyltransferase 4. (344 aa)
	Naga	Alpha-galactosidase. (415 aa)
	St6gal1	Beta-galactoside alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (402 aa)
	Mecp2	Methyl-CpG-binding protein 2. (203 aa)
	Cpd	Carboxypeptidase D. (1106 aa)
	Mgat4b	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B. (612 aa)
	Glul-2	Glutamine synthetase. (373 aa)
	Mgat1	Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase. (447 aa)
	Sppl3	Signal peptide peptidase-like 3. (347 aa)
	Trim24	Transcription intermediary factor 1-alpha. (493 aa)
	Glul	Glutamine synthetase; Belongs to the glutamine synthetase family. (297 aa)
	St3gal4	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 3-sialyltransferase; Belongs to the glycosyltransferase 29 family. (359 aa)
	St3gal3	CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase; Belongs to the glycosyltransferase 29 family. (398 aa)
	B4galt2	Beta-1,4-galactosyltransferase 2. (369 aa)
	B3gnt2	Hexosyltransferase. (397 aa)
	Bcl2	Apoptosis regulator Bcl-2. (203 aa)
	Calr	Calreticulin. (417 aa)
	Fut8	Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (575 aa)
	I79_006254	Bone morphogenetic protein 4. (406 aa)
	Lpl	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (450 aa)
	Tet1	Methylcytosine dioxygenase TET1. (1466 aa)
	Cdt1	DNA replication factor Cdt1. (553 aa)
	Gla	Alpha-galactosidase. (341 aa)
	Calr3	Calreticulin. (380 aa)
	Hpd	4-hydroxyphenylpyruvate dioxygenase. (393 aa)
	Mgat5	Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A. (740 aa)
	Slc35c1	GDP-fucose transporter 1. (365 aa)
	C1s	Calcium-dependent serine proteinase; Belongs to the peptidase S1 family. (695 aa)
	Lig4	DNA ligase. (912 aa)
	DHFR	Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. (187 aa)
	Csf3	Granulocyte colony-stimulating factor. (208 aa)
	Abhd11	Abhydrolase domain-containing protein 11. (307 aa)
	Casp7	Caspase-7. (303 aa)
	Xrcc6	ATP-dependent DNA helicase 2 subunit 1. (608 aa)
	Tlr3	Toll-like receptor 3. (164 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Anxa2	Calr	G3IG05	G3HCX8	Annexin.	Calreticulin.	0.448
B3gnt2	B4galt1	G3HDQ9	G3I8W2	Hexosyltransferase.	Beta-1,4-galactosyltransferase 1.	0.928
B3gnt2	B4galt2	G3HDQ9	G3HFF7	Hexosyltransferase.	Beta-1,4-galactosyltransferase 2.	0.924
B3gnt2	B4galt4	G3HDQ9	G3I1K4	Hexosyltransferase.	Beta-1,4-galactosyltransferase 4.	0.936
B3gnt2	Fut8	G3HDQ9	G3HCE4	Hexosyltransferase.	Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family.	0.708
B3gnt2	Mgat5	G3HDQ9	G3GZF3	Hexosyltransferase.	Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A.	0.555
B3gnt2	Sppl3	G3HDQ9	G3HI62	Hexosyltransferase.	Signal peptide peptidase-like 3.	0.896
B3gnt2	St3gal3	G3HDQ9	G3HFG3	Hexosyltransferase.	CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase; Belongs to the glycosyltransferase 29 family.	0.733
B3gnt2	St3gal6	G3HDQ9	G3I3V5	Hexosyltransferase.	Type 2 lactosamine alpha-2,3-sialyltransferase; Belongs to the glycosyltransferase 29 family.	0.934
B3gnt2	St6gal1	G3HDQ9	G3HYF9	Hexosyltransferase.	Beta-galactoside alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family.	0.461
B4galt1	B3gnt2	G3I8W2	G3HDQ9	Beta-1,4-galactosyltransferase 1.	Hexosyltransferase.	0.928
B4galt1	B4galt2	G3I8W2	G3HFF7	Beta-1,4-galactosyltransferase 1.	Beta-1,4-galactosyltransferase 2.	0.939
B4galt1	B4galt4	G3I8W2	G3I1K4	Beta-1,4-galactosyltransferase 1.	Beta-1,4-galactosyltransferase 4.	0.941
B4galt1	Fut8	G3I8W2	G3HCE4	Beta-1,4-galactosyltransferase 1.	Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family.	0.974
B4galt1	Mgat4b	G3I8W2	G3HP67	Beta-1,4-galactosyltransferase 1.	Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B.	0.715
B4galt1	Mgat5	G3I8W2	G3GZF3	Beta-1,4-galactosyltransferase 1.	Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A.	0.707
B4galt1	Slc35c1	G3I8W2	G3GYH6	Beta-1,4-galactosyltransferase 1.	GDP-fucose transporter 1.	0.468
B4galt1	St3gal3	G3I8W2	G3HFG3	Beta-1,4-galactosyltransferase 1.	CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase; Belongs to the glycosyltransferase 29 family.	0.969
B4galt1	St3gal4	G3I8W2	G3HFJ0	Beta-1,4-galactosyltransferase 1.	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 3-sialyltransferase; Belongs to the glycosyltransferase 29 family.	0.693
B4galt1	St3gal6	G3I8W2	G3I3V5	Beta-1,4-galactosyltransferase 1.	Type 2 lactosamine alpha-2,3-sialyltransferase; Belongs to the glycosyltransferase 29 family.	0.945