(16 nodes) (2023) Optic nerve diseases and regeneration: How far are we from the promised land? network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Aqp4	Aquaporin-4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (236 aa)
	I79_001600	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
	Cd68	Macrosialin. (294 aa)
	I79_004417	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	Socs3	Suppressor of cytokine signaling 3. (225 aa)
	Tet1	Methylcytosine dioxygenase TET1. (1466 aa)
	Bcl2	Apoptosis regulator Bcl-2. (203 aa)
	Stat3	Signal transducer and activator of transcription. (770 aa)
	I79_017529	Apoptotic protease-activating factor 1. (444 aa)
	I79_017669	Apoptotic protease-activating factor 1. (434 aa)
	I79_018057	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
	Epo	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
	Cxcl12	Stromal cell-derived factor 1. (89 aa)
	Ocm2	Oncomodulin; Belongs to the parvalbumin family. (128 aa)
	I79_021949	Caspase-3; Belongs to the peptidase C14A family. (195 aa)
	Cxcr2	High affinity interleukin-8 receptor B; Belongs to the G-protein coupled receptor 1 family. (359 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Aqp4	I79_021949	G3HDY9	G3IE08	Aquaporin-4; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Caspase-3; Belongs to the peptidase C14A family.	0.426
Bcl2	I79_001600	G3HD46	G3GV69	Apoptosis regulator Bcl-2.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.993
Bcl2	I79_004417	G3HD46	G3H2K2	Apoptosis regulator Bcl-2.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.994
Bcl2	I79_017529	G3HD46	G3I2A0	Apoptosis regulator Bcl-2.	Apoptotic protease-activating factor 1.	0.768
Bcl2	I79_017669	G3HD46	G3I2M9	Apoptosis regulator Bcl-2.	Apoptotic protease-activating factor 1.	0.768
Bcl2	I79_018057	G3HD46	G3I3P7	Apoptosis regulator Bcl-2.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.994
Bcl2	I79_021949	G3HD46	G3IE08	Apoptosis regulator Bcl-2.	Caspase-3; Belongs to the peptidase C14A family.	0.938
Bcl2	Stat3	G3HD46	G3HLW9	Apoptosis regulator Bcl-2.	Signal transducer and activator of transcription.	0.697
Cd68	I79_021949	G3GY73	G3IE08	Macrosialin.	Caspase-3; Belongs to the peptidase C14A family.	0.492
Cd68	Stat3	G3GY73	G3HLW9	Macrosialin.	Signal transducer and activator of transcription.	0.418
Cxcl12	Cxcr2	G3I6P7	G3IMN7	Stromal cell-derived factor 1.	High affinity interleukin-8 receptor B; Belongs to the G-protein coupled receptor 1 family.	0.973
Cxcl12	Stat3	G3I6P7	G3HLW9	Stromal cell-derived factor 1.	Signal transducer and activator of transcription.	0.465
Cxcr2	Cxcl12	G3IMN7	G3I6P7	High affinity interleukin-8 receptor B; Belongs to the G-protein coupled receptor 1 family.	Stromal cell-derived factor 1.	0.973
Epo	I79_021949	G3I675	G3IE08	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Caspase-3; Belongs to the peptidase C14A family.	0.539
Epo	Stat3	G3I675	G3HLW9	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Signal transducer and activator of transcription.	0.431
I79_001600	Bcl2	G3GV69	G3HD46	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Apoptosis regulator Bcl-2.	0.993
I79_001600	I79_004417	G3GV69	G3H2K2	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.901
I79_001600	I79_017529	G3GV69	G3I2A0	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Apoptotic protease-activating factor 1.	0.998
I79_001600	I79_017669	G3GV69	G3I2M9	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Apoptotic protease-activating factor 1.	0.998
I79_001600	I79_018057	G3GV69	G3I3P7	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.901