(29 nodes) (2023) Regulatory Functions of Hypoxia in Host-Parasite Interactions: A Focus on Enteric, Tissue, and Blood Protozoa. network (Cricetulus griseus)

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second shell of interactors

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Predicted Interactions

gene neighborhood

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Your Input:
	Bnip3	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (151 aa)
	Il1rn	Interleukin-1. (157 aa)
	CgPICR_017245	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
	ICAM1	Intercellular adhesion molecule 1. (527 aa)
	Edn1	Endothelin-1. (202 aa)
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	Cldn1	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	Lyrm9	Nitric oxide synthase; Produces nitric oxide (NO); Belongs to the complex I LYR family. (1115 aa)
	Nos1	Nitric oxide synthase; Produces nitric oxide (NO). (1413 aa)
	Skp1	S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
	Cryab	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
	Gpx3	Glutathione peroxidase 3. (53 aa)
	I79_007693	Nitric oxide synthase; Produces nitric oxide (NO). (1129 aa)
	CgPICR_018649	Alpha-enolase. (111 aa)
	Pgk1	Phosphoglycerate kinase. (242 aa)
	Ocln	Occludin. (488 aa)
	Sod2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
	Atg9a	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (839 aa)
	Cldn2	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
	Tlr4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
	I79_017574	Caspase-12; Belongs to the peptidase C14A family. (729 aa)
	Ankrd37	Ankyrin repeat domain-containing protein 37. (154 aa)
	Cxcl1	C-X-C motif chemokine. (101 aa)
	Il33	Interleukin-33. (217 aa)
	Epo	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
	Vegfb	Vascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (150 aa)
	Sucnr1	Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (244 aa)
	Ccn2	Connective tissue growth factor-like protein. (348 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ankrd37	Bnip3	G3I3L6	G3IFW8	Ankyrin repeat domain-containing protein 37.	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3.	0.526
Bnip3	Ankrd37	G3IFW8	G3I3L6	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3.	Ankyrin repeat domain-containing protein 37.	0.526
Bnip3	IL1B	G3IFW8	G3I1B0	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.493
Bnip3	Sod2	G3IFW8	G3HWB8	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.496
Bnip3	Tlr4	G3IFW8	G3I192	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.407
Ccn2	Edn1	G3IAP3	G3H0G9	Connective tissue growth factor-like protein.	Endothelin-1.	0.729
CgPICR_017245	Cldn1	G3IMK5	G3GT81	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.811
CgPICR_017245	Cldn2	G3IMK5	G3I169	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.688
CgPICR_017245	Ocln	G3IMK5	G3HRV7	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Occludin.	0.942
CgPICR_018649	Pgk1	G3HJB3	G3HNY5	Alpha-enolase.	Phosphoglycerate kinase.	0.724
Cldn1	CgPICR_017245	G3GT81	G3IMK5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.811
Cldn1	Cldn2	G3GT81	G3I169	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.743
Cldn1	Ifng	G3GT81	G3GY20	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.421
Cldn1	Ocln	G3GT81	G3HRV7	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Occludin.	0.985
Cldn1	Tlr4	G3GT81	G3I192	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.547
Cldn2	CgPICR_017245	G3I169	G3IMK5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.688
Cldn2	Cldn1	G3I169	G3GT81	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.743
Cldn2	Ocln	G3I169	G3HRV7	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Occludin.	0.884
Cxcl1	ICAM1	G3I473	Q9ERF7	C-X-C motif chemokine.	Intercellular adhesion molecule 1.	0.594
Cxcl1	IL1B	G3I473	G3I1B0	C-X-C motif chemokine.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.780