(11 nodes) (2023) Diversity in Notch ligand-receptor signaling interactions. network (Cricetulus griseus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	Dll4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (578 aa)
	Alb	Serum albumin. (430 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2527 aa)
	Mat2a	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (332 aa)
	Dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (741 aa)
	Plp2	Proteolipid protein 2. (151 aa)
	Heyl	Hairy/enhancer-of-split related with YRPW motif-like protein. (300 aa)
	Rfng	Beta-1,3-N-acetylglucosaminyltransferase radical fringe. (229 aa)
	Jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1186 aa)
	Adam10	Disintegrin and metalloproteinase domain-containing protein 10. (675 aa)
	I79_025220	Serum albumin. (186 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adam10	Dll1	G3GRM2	G3HNT7	Disintegrin and metalloproteinase domain-containing protein 10.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.698
Adam10	Dll4	G3GRM2	G3ICK3	Disintegrin and metalloproteinase domain-containing protein 10.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.523
Adam10	Jag1	G3GRM2	G3GSA7	Disintegrin and metalloproteinase domain-containing protein 10.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.553
Adam10	NOTCH1	G3GRM2	G3I6Z6	Disintegrin and metalloproteinase domain-containing protein 10.	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...]	0.737
Alb	I79_025220	G3IAL6	G3IMS5	Serum albumin.	Serum albumin.	0.960
Dll1	Adam10	G3HNT7	G3GRM2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Disintegrin and metalloproteinase domain-containing protein 10.	0.698
Dll1	Dll4	G3HNT7	G3ICK3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.942
Dll1	Heyl	G3HNT7	G3HN78	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hairy/enhancer-of-split related with YRPW motif-like protein.	0.529
Dll1	Jag1	G3HNT7	G3GSA7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.577
Dll1	NOTCH1	G3HNT7	G3I6Z6	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...]	0.995
Dll1	Rfng	G3HNT7	G3GXD4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Beta-1,3-N-acetylglucosaminyltransferase radical fringe.	0.652
Dll4	Adam10	G3ICK3	G3GRM2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Disintegrin and metalloproteinase domain-containing protein 10.	0.523
Dll4	Dll1	G3ICK3	G3HNT7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.942
Dll4	Heyl	G3ICK3	G3HN78	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hairy/enhancer-of-split related with YRPW motif-like protein.	0.513
Dll4	Jag1	G3ICK3	G3GSA7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.503
Dll4	NOTCH1	G3ICK3	G3I6Z6	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...]	0.998
Dll4	Rfng	G3ICK3	G3GXD4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Beta-1,3-N-acetylglucosaminyltransferase radical fringe.	0.517
Heyl	Dll1	G3HN78	G3HNT7	Hairy/enhancer-of-split related with YRPW motif-like protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.529
Heyl	Dll4	G3HN78	G3ICK3	Hairy/enhancer-of-split related with YRPW motif-like protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.513
Heyl	Jag1	G3HN78	G3GSA7	Hairy/enhancer-of-split related with YRPW motif-like protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.618