STRINGSTRING
Akt2 Akt2 Atf4 Atf4 Jak2 Jak2 Mtor Mtor I79_021949 I79_021949 Lcn2 Lcn2 I79_020089 I79_020089 Xiap Xiap HSPA5 HSPA5 Rel Rel Ccl5 Ccl5 I79_018057 I79_018057 Tlr4 Tlr4 Akt3 Akt3 Hus1 Hus1 Nfkb2 Nfkb2 Gli1 Gli1 PPARG PPARG Becn1 Becn1 Stat3 Stat3 Cdc25a Cdc25a Bcl2 Bcl2 I79_007693 I79_007693 Mmp9 Mmp9 Igf1 Igf1 I79_004417 I79_004417 Src Src Fasn Fasn Hus1b Hus1b I79_001600 I79_001600 Nos1 Nos1 Lyrm9 Lyrm9 Ccnd1 Ccnd1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Akt2Non-specific serine/threonine protein kinase. (200 aa)
Atf4Cyclic AMP-dependent transcription factor ATF-4. (348 aa)
Jak2Tyrosine-protein kinase. (1122 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
I79_021949Caspase-3; Belongs to the peptidase C14A family. (195 aa)
Lcn2Neutrophil gelatinase-associated lipocalin; Belongs to the calycin superfamily. Lipocalin family. (229 aa)
I79_020089Caspase-9; Belongs to the peptidase C14A family. (689 aa)
XiapBaculoviral IAP repeat-containing protein 4. (441 aa)
HSPA5Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (654 aa)
RelC-Rel proto-oncogene protein. (566 aa)
Ccl5C-C motif chemokine. (91 aa)
I79_018057Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
Akt3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
Hus1Checkpoint protein; Belongs to the HUS1 family. (281 aa)
Nfkb2Nuclear factor NF-kappa-B p100 subunit. (306 aa)
Gli1Zinc finger protein GLI1. (1104 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Becn1Beclin-1. (448 aa)
Stat3Signal transducer and activator of transcription. (770 aa)
Cdc25aM-phase inducer phosphatase 1. (121 aa)
Bcl2Apoptosis regulator Bcl-2. (203 aa)
I79_007693Nitric oxide synthase; Produces nitric oxide (NO). (1129 aa)
Mmp9Matrix metalloproteinase-9. (710 aa)
Igf1Insulin-like growth factor I. (75 aa)
I79_004417Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
SrcTyrosine-protein kinase. (536 aa)
FasnFatty acid synthase. (2503 aa)
Hus1bCheckpoint protein; Belongs to the HUS1 family. (277 aa)
I79_001600Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
Nos1Nitric oxide synthase; Produces nitric oxide (NO). (1413 aa)
Lyrm9Nitric oxide synthase; Produces nitric oxide (NO); Belongs to the complex I LYR family. (1115 aa)
Ccnd1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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