STRINGSTRING
Umps Umps IMPDH IMPDH Gmps Gmps Tk1 Tk1 ITPA ITPA Tk2 Tk2 Mgst1 Mgst1 H671_7g18194 H671_7g18194 CgPICR_020542 CgPICR_020542 Nme3 Nme3 Hprt1 Hprt1 Uckl1 Uckl1 I79_009940 I79_009940 Upp2 Upp2 Nme6 Nme6 Rrm2b Rrm2b Uck2 Uck2 Mgst3 Mgst3 CgPICR_015959 CgPICR_015959 I79_015930 I79_015930 I79_015931 I79_015931 I79_015932 I79_015932 Upb1 Upb1 Nme7 Nme7 Rrm2 Rrm2 Rrm1 Rrm1 Gstp1 Gstp1 I79_018158 I79_018158 Xdh Xdh I79_018719 I79_018719 I79_018758 I79_018758 I79_019350 I79_019350 I79_019351 I79_019351 I79_019352 I79_019352 I79_019354 I79_019354 I79_019629 I79_019629 Upp1 Upp1 Dpyd Dpyd Uck1 Uck1 I79_021042 I79_021042 Gusb Gusb I79_022242 I79_022242 I79_022517 I79_022517 I79_022518 I79_022518 I79_023022 I79_023022 I79_023024 I79_023024 I79_023111 I79_023111 CgPICR_009695 CgPICR_009695 I79_023630 I79_023630 I79_023814 I79_023814 I79_024324 I79_024324 I79_024436 I79_024436 Gstm3 Gstm3 I79_024716 I79_024716 I79_024718 I79_024718 I79_025478 I79_025478 IMPDH2 IMPDH2 nat nat
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UmpsUridine 5'-monophosphate synthase. (480 aa)
IMPDHInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (437 aa)
GmpsGMP synthase [glutamine-hydrolyzing]. (1159 aa)
Tk1Thymidine kinase. (234 aa)
ITPAInosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (196 aa)
Tk2Thymidine kinase 2, mitochondrial. (264 aa)
Mgst1Microsomal glutathione S-transferase 1. (155 aa)
H671_7g18194Nucleoside diphosphate kinase. (152 aa)
CgPICR_020542Nucleoside diphosphate kinase. (152 aa)
Nme3Nucleoside diphosphate kinase. (169 aa)
Hprt1Hypoxanthine-guanine phosphoribosyltransferase. (76 aa)
Uckl1Uridine-cytidine kinase; Belongs to the uridine kinase family. (334 aa)
I79_009940Glutathione S-transferase A1; Belongs to the GST superfamily. (223 aa)
Upp2Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (250 aa)
Nme6Nucleoside diphosphate kinase. (186 aa)
Rrm2bRibonucleoside-diphosphate reductase subunit M2 B. (114 aa)
Uck2Uridine-cytidine kinase 2. (235 aa)
Mgst3Microsomal glutathione S-transferase 3. (152 aa)
CgPICR_015959Glutathione S-transferase theta-1; Belongs to the GST superfamily. (241 aa)
I79_015930Glutathione S-transferase theta-1; Belongs to the GST superfamily. (240 aa)
I79_015931Glutathione S-transferase theta-4; Belongs to the GST superfamily. (240 aa)
I79_015932Glutathione S-transferase theta-2. (244 aa)
Upb1Beta-ureidopropionase. (393 aa)
Nme7Nucleoside diphosphate kinase 7; Belongs to the NDK family. (160 aa)
Rrm2Ribonucleoside-diphosphate reductase subunit M2. (390 aa)
Rrm1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa)
Gstp1Glutathione S-transferase P. (221 aa)
I79_018158Glutathione S-transferase P 2. (210 aa)
XdhXanthine dehydrogenase/oxidase. (1332 aa)
I79_018719Glutathione S-transferase A4; Belongs to the GST superfamily. (222 aa)
I79_018758UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (448 aa)
I79_019350Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (128 aa)
I79_019351Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (561 aa)
I79_019352Liver carboxylesterase; Belongs to the type-B carboxylesterase/lipase family. (795 aa)
I79_019354Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (545 aa)
I79_019629Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (564 aa)
Upp1Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (282 aa)
DpydDihydropyrimidine dehydrogenase [NADP+]. (74 aa)
Uck1Dynamin-1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (948 aa)
I79_021042UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
GusbBeta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (648 aa)
I79_022242UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (535 aa)
I79_022517Glutathione S-transferase alpha-5. (128 aa)
I79_022518Glutathione S-transferase alpha-3. (128 aa)
I79_023022UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (218 aa)
I79_023024UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (526 aa)
I79_023111UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (218 aa)
CgPICR_009695Cytochrome P450 2E1; Belongs to the cytochrome P450 family. (493 aa)
I79_023630Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (561 aa)
I79_023814Arylamine N-acetyltransferase 1; Belongs to the arylamine N-acetyltransferase family. (290 aa)
I79_024324Glutathione S-transferase Mu 6; Belongs to the GST superfamily. (740 aa)
I79_024436Glutathione S-transferase omega-2. (163 aa)
Gstm3Glutathione S-transferase. (227 aa)
I79_024716Glutathione S-transferase. (265 aa)
I79_024718Glutathione S-transferase. (218 aa)
I79_025478Glutathione S-transferase Mu 1. (218 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase 2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. Belongs to the IMPDH/GMPR family. (514 aa)
natArylamine N-acetyltransferase 2; Belongs to the arylamine N-acetyltransferase family. (290 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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