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Pfkp Pfkp Suclg2 Suclg2 Hao1 Hao1 I79_000715 I79_000715 I79_001391 I79_001391 Eno2 Eno2 Tkt Tkt Acox3 Acox3 I79_002237 I79_002237 Hadha Hadha Eno3 Eno3 Cat Cat Glyctk Glyctk Pgam1 Pgam1 Got1 Got1 Idh3a Idh3a Hk3 Hk3 Got1l1 Got1l1 Dlat Dlat Pkm Pkm Rgn Rgn Idh3b Idh3b Pgls Pgls Agxt Agxt Rpe Rpe PDH-A1 PDH-A1 Fh Fh Hk1 Hk1 Hkdc1 Hkdc1 Acss1 Acss1 Amt Amt H671_1g1921 H671_1g1921 Pfkl Pfkl Acss2 Acss2 Pgp Pgp Pklr Pklr CgPICR_016797 CgPICR_016797 Mdh1 Mdh1 Adpgk Adpgk Dlst Dlst CgPICR_011488 CgPICR_011488 Pcca Pcca Acads Acads Tktl2 Tktl2 Aldob Aldob Ehhadh Ehhadh Pgam2 Pgam2 Gck Gck Ogdh Ogdh I79_011887 I79_011887 Aldh6a1 Aldh6a1 Pgk1 Pgk1 Phgdh Phgdh SUCLG1 SUCLG1 Mcee Mcee Cs Cs Tktl1 Tktl1 Idh3g Idh3g Me2 Me2 Acox1 Acox1 Sdhc Sdhc Idh1 Idh1 Shmt2 Shmt2 Gpt Gpt Sucla2 Sucla2 Gcsh Gcsh Acat1 Acat1 Pccb Pccb Dld Dld Psph Psph Got2 Got2 Taldo1 Taldo1 Esd Esd CgPICR_016294 CgPICR_016294 Aldoa Aldoa PC PC I79_018485 I79_018485 I79_018923 I79_018923 Mmut Mmut Sdsl Sdsl Sds Sds H6pd H6pd CgPICR_011545 CgPICR_011545 Gpt2 Gpt2 CgPICR_015813 CgPICR_015813 Prps2 Prps2 I79_020676 I79_020676 I79_020703 I79_020703 G6pd G6pd Pfkm Pfkm Sdhb Sdhb Sdha Sdha Hk2 Hk2 Hibch Hibch Idh2 Idh2 Mthfr Mthfr Pgd Pgd Aco2 Aco2 Tkfc Tkfc Aldoc Aldoc Psat1 Psat1 I79_024784 I79_024784 I79_024892 I79_024892 Adh5 Adh5
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
PfkpATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (793 aa)
Suclg2Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial. (358 aa)
Hao1Hydroxyacid oxidase 1. (373 aa)
I79_000715Glyceraldehyde-3-phosphate dehydrogenase. (161 aa)
I79_001391Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (260 aa)
Eno2Gamma-enolase. (434 aa)
TktTransketolase. (623 aa)
Acox3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (700 aa)
I79_002237Alpha-enolase. (217 aa)
HadhaTrifunctional enzyme subunit alpha, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
Eno3Beta-enolase. (270 aa)
CatCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (555 aa)
GlyctkGlycerate kinase. (396 aa)
Pgam1Phosphoglycerate mutase 1. (178 aa)
Got1Aspartate aminotransferase. (413 aa)
Idh3aIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (366 aa)
Hk3Hexokinase-3. (867 aa)
Got1l1Putative aspartate aminotransferase, cytoplasmic 2. (791 aa)
DlatAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (646 aa)
PkmPyruvate kinase; Belongs to the pyruvate kinase family. (472 aa)
RgnRegucalcin. (265 aa)
Idh3bIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (385 aa)
Pgls6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (169 aa)
AgxtSerine--pyruvate aminotransferase. (414 aa)
RpeRibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)
PDH-A1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
FhFumarate hydratase, mitochondrial. (507 aa)
Hk1Hexokinase-1. (917 aa)
Hkdc1Putative hexokinase HKDC1. (925 aa)
Acss1Acetyl-coenzyme A synthetase. (577 aa)
AmtAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (409 aa)
H671_1g1921Dihydrolipoyl dehydrogenase, mitochondrial. (180 aa)
Pfkl6-phosphofructokinase; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily. (745 aa)
Acss2Acetyl-coenzyme A synthetase, cytoplasmic. (391 aa)
PgpPhosphoglycolate phosphatase. (617 aa)
PklrPyruvate kinase; Belongs to the pyruvate kinase family. (543 aa)
CgPICR_016797Ribose-phosphate pyrophosphokinase 1. (318 aa)
Mdh1Malate dehydrogenase. (334 aa)
AdpgkADP-dependent glucokinase. (496 aa)
DlstDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (308 aa)
CgPICR_011488Acetyl-CoA acetyltransferase, cytosolic; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
PccaPropionyl-CoA carboxylase alpha chain, mitochondrial. (869 aa)
AcadsShort-chain specific acyl-CoA dehydrogenase, mitochondrial. (412 aa)
Tktl2Transketolase-like protein 2. (627 aa)
AldobFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
EhhadhPeroxisomal bifunctional enzyme. (701 aa)
Pgam2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
GckPhosphotransferase. (465 aa)
Ogdh2-oxoglutarate dehydrogenase E1 component, mitochondrial. (917 aa)
I79_011887Glyceraldehyde-3-phosphate dehydrogenase. (342 aa)
Aldh6a1Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial. (243 aa)
Pgk1Phosphoglycerate kinase. (242 aa)
PhgdhD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
SUCLG1Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (333 aa)
MceeMethylmalonyl-CoA epimerase, mitochondrial. (178 aa)
CsCitrate synthase; Belongs to the citrate synthase family. (313 aa)
Tktl1Transketolase-like protein 1. (100 aa)
Idh3gIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (335 aa)
Me2Malic enzyme. (584 aa)
Acox1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (556 aa)
SdhcSuccinate dehydrogenase cytochrome b560 subunit, mitochondrial. (132 aa)
Idh1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
Shmt2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
GptAlanine aminotransferase 1. (481 aa)
Sucla2Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial. (238 aa)
GcshGlycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (170 aa)
Acat1Acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. (424 aa)
PccbPropionyl-CoA carboxylase beta chain, mitochondrial. (539 aa)
DldDihydrolipoyl dehydrogenase. (509 aa)
PsphPhosphoserine phosphatase. (250 aa)
Got2Aspartate aminotransferase. (430 aa)
Taldo1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (337 aa)
EsdS-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (282 aa)
CgPICR_016294Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
AldoaFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
PCPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1178 aa)
I79_018485Isocitrate dehydrogenase [NADP] cytoplasmic. (235 aa)
I79_018923Ribose-phosphate pyrophosphokinase 1. (177 aa)
MmutMethylmalonyl-CoA mutase, mitochondrial. (599 aa)
SdslSerine dehydratase-like. (298 aa)
SdsL-serine dehydratase/L-threonine deaminase. (327 aa)
H6pdGDH/6PGL endoplasmic bifunctional protein. (789 aa)
CgPICR_011545Ribose-5-phosphate isomerase. (161 aa)
Gpt2Alanine aminotransferase 2. (470 aa)
CgPICR_015813Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial. (399 aa)
Prps2Ribose-phosphate pyrophosphokinase 2. (318 aa)
I79_020676Alpha-enolase. (429 aa)
I79_020703Putative gluconokinase. (98 aa)
G6pdGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (624 aa)
PfkmATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
SdhbSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (223 aa)
SdhaSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (653 aa)
Hk2Hexokinase-2. (704 aa)
Hibch3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (358 aa)
Idh2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
MthfrMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (644 aa)
Pgd6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (483 aa)
Aco2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (780 aa)
TkfcBifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (Cyclizing). (578 aa)
AldocFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (363 aa)
Psat1Phosphoserine aminotransferase. (309 aa)
I79_024784Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (327 aa)
I79_024892Fructose-1,6-bisphosphatase 1. (66 aa)
Adh5S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (326 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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