55 items (Cricetulus griseus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ccnd1	G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
	Casp8	Caspase-8; Belongs to the peptidase C14A family. (481 aa)
	Ccnb2	G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (398 aa)
	Ccnd2	G1/S-specific cyclin-D2; Belongs to the cyclin family. (288 aa)
	I79_001515	Tumor necrosis factor receptor superfamily member 10B. (320 aa)
	I79_001600	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (118 aa)
	I79_001975	P53 apoptosis effector related to PMP-22. (121 aa)
	Cdk6	Cell division protein kinase 6. (273 aa)
	Sesn1	Sestrin-1. (551 aa)
	Mdm2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (476 aa)
	Tp53	Cellular tumor antigen p53. (148 aa)
	Cd82	Tetraspanin. (249 aa)
	Tp53i3	Quinone oxidoreductase PIG3-like protein. (331 aa)
	Sesn2	Sestrin-2. (480 aa)
	I79_004417	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	Siva1	Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa)
	Steap3	Metalloreductase STEAP3. (488 aa)
	Igf1	Insulin-like growth factor I. (75 aa)
	Sesn3	Sestrin-3. (414 aa)
	Ccng1	Cyclin-G1-like protein; Belongs to the cyclin family. (294 aa)
	Cop1	E3 ubiquitin-protein ligase RFWD2. (556 aa)
	Serpine1	Plasminogen activator inhibitor 1; Belongs to the serpin family. (270 aa)
	Tsc2	Tuberin. (1546 aa)
	Chek2	Serine/threonine-protein kinase Chk2. (539 aa)
	Serpinb5	Serpin B5; Belongs to the serpin family. (375 aa)
	Bcl2	Apoptosis regulator Bcl-2. (203 aa)
	Bcl2l1	Bcl-2-like protein 1. (233 aa)
	Thbs1	Thrombospondin-1. (533 aa)
	Ccne2	G1/S-specific cyclin-E2. (134 aa)
	Gadd45g	Growth arrest and DNA-damage-inducible protein GADD45 gamma. (165 aa)
	Cdkn1a	Cyclin-dependent kinase inhibitor 1. (163 aa)
	Shisa5	Protein shisa-5. (242 aa)
	Rrm2b	Ribonucleoside-diphosphate reductase subunit M2 B. (114 aa)
	Igfbp3	Insulin-like growth factor-binding protein 3. (75 aa)
	Gorab	RAB6-interacting golgin. (367 aa)
	Bid	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (194 aa)
	Fas	Tumor necrosis factor receptor superfamily member 6. (124 aa)
	Ccnd3	G1/S-specific cyclin-D3; Belongs to the cyclin family. (353 aa)
	Ccnb1	G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (409 aa)
	Gadd45b	Growth arrest and DNA-damage-inducible protein GADD45 beta. (232 aa)
	Cdk1	Cell division control protein 2-like; Belongs to the protein kinase superfamily. (297 aa)
	I79_015181	14-3-3 protein sigma; Belongs to the 14-3-3 family. (249 aa)
	Sfn	14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
	Siah1	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (282 aa)
	Bax	Apoptosis regulator BAX. (521 aa)
	Zmat3	Zinc finger matrin-type protein 3. (290 aa)
	Rrm2	Ribonucleoside-diphosphate reductase subunit M2. (390 aa)
	Pidd1	Leucine-rich repeat and death domain-containing protein. (915 aa)
	I79_018057	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
	Ccne1	G1/S-specific cyclin-E1; Belongs to the cyclin family. (291 aa)
	Chek1	Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (476 aa)
	Ei24	Etoposide-induced protein 2.4-like. (341 aa)
	Rchy1	RING finger and CHY zinc finger domain-containing protein 1. (259 aa)
	Rprm	Protein reprimo-like protein. (109 aa)
	Gtse1	G2 and S phase-expressed protein 1. (749 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bax	Bcl2	G3HZX7	G3HD46	Apoptosis regulator BAX.	Apoptosis regulator Bcl-2.	0.901
Bax	Bcl2l1	G3HZX7	G3HEA7	Apoptosis regulator BAX.	Bcl-2-like protein 1.	0.901
Bax	Bid	G3HZX7	G3HQ86	Apoptosis regulator BAX.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.900
Bax	I79_001600	G3HZX7	G3GV69	Apoptosis regulator BAX.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.914
Bax	I79_004417	G3HZX7	G3H2K2	Apoptosis regulator BAX.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.914
Bax	I79_018057	G3HZX7	G3I3P7	Apoptosis regulator BAX.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.914
Bax	Tp53	G3HZX7	G3GY68	Apoptosis regulator BAX.	Cellular tumor antigen p53.	0.901
Bcl2	Bax	G3HD46	G3HZX7	Apoptosis regulator Bcl-2.	Apoptosis regulator BAX.	0.901
Bcl2	Bcl2l1	G3HD46	G3HEA7	Apoptosis regulator Bcl-2.	Bcl-2-like protein 1.	0.902
Bcl2	Bid	G3HD46	G3HQ86	Apoptosis regulator Bcl-2.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.981
Bcl2	Casp8	G3HD46	B2CMK5	Apoptosis regulator Bcl-2.	Caspase-8; Belongs to the peptidase C14A family.	0.860
Bcl2	Ccnd1	G3HD46	A5A422	Apoptosis regulator Bcl-2.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.770
Bcl2	Cdk6	G3HD46	G3GXH4	Apoptosis regulator Bcl-2.	Cell division protein kinase 6.	0.531
Bcl2	Cdkn1a	G3HD46	G3HKC6	Apoptosis regulator Bcl-2.	Cyclin-dependent kinase inhibitor 1.	0.480
Bcl2	I79_001600	G3HD46	G3GV69	Apoptosis regulator Bcl-2.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.993
Bcl2	I79_004417	G3HD46	G3H2K2	Apoptosis regulator Bcl-2.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.994
Bcl2	I79_018057	G3HD46	G3I3P7	Apoptosis regulator Bcl-2.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.994
Bcl2	Igf1	G3HD46	G3H672	Apoptosis regulator Bcl-2.	Insulin-like growth factor I.	0.440
Bcl2	Mdm2	G3HD46	G3GY28	Apoptosis regulator Bcl-2.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.569
Bcl2	Siva1	G3HD46	G3H396	Apoptosis regulator Bcl-2.	Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.	0.931