STRINGSTRING
AEW92572.1 AEW92572.1 AEW92766.1 AEW92766.1 dapD dapD leuA leuA AEW94442.1 AEW94442.1 serC serC AEW94805.1 AEW94805.1 asd asd dapA dapA ilvD ilvD ilvE ilvE asd-2 asd-2 AEW95306.1 AEW95306.1 AEW95682.1 AEW95682.1 AEW96345.1 AEW96345.1 AEW96347.1 AEW96347.1 AEW96348.1 AEW96348.1 AEW96351.1 AEW96351.1 lysA-2 lysA-2 AEW96534.1 AEW96534.1 AEW96535.1 AEW96535.1 thrB thrB AEW96691.1 AEW96691.1 AEW96694.1 AEW96694.1 AEW96695.1 AEW96695.1 ilvC ilvC AEW96698.1 AEW96698.1 AEW96713.1 AEW96713.1 AEW96714.1 AEW96714.1 AEW96720.1 AEW96720.1 leuC leuC leuD leuD dapB dapB dapA-2 dapA-2 dapF dapF AEW97648.1 AEW97648.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AEW92572.1Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (609 aa)
AEW92766.1Dihydrodipicolinate synthetase protein; Belongs to the DapA family. (268 aa)
dapDTransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (331 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (590 aa)
AEW94442.1Lysine/ornithine decarboxylase. (459 aa)
serCPutative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (372 aa)
AEW94805.1Threonine synthase. (426 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (346 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (327 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (612 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (332 aa)
asd-2Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (354 aa)
AEW95306.1Aspartate kinase; Belongs to the aspartokinase family. (424 aa)
AEW95682.1Aminotransferase. (392 aa)
AEW96345.1Hypothetical protein. (279 aa)
AEW96347.1Putative ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (106 aa)
AEW96348.1N-succinyldiaminopimelate aminotransferase. (366 aa)
AEW96351.1Succinyl-diaminopimelate desuccinylase. (355 aa)
lysA-2Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (463 aa)
AEW96534.1Homoserine dehydrogenase. (446 aa)
AEW96535.1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (362 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (315 aa)
AEW96691.1Dehydrogenase. (294 aa)
AEW96694.1Acetolactate synthase 1 catalytic subunit. (589 aa)
AEW96695.1Acetolactate synthase 3 regulatory subunit. (175 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa)
AEW96698.1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa)
AEW96713.13-isopropylmalate dehydrogenase. (327 aa)
AEW96714.1Branched-chain amino acid aminotransferase. (367 aa)
AEW96720.1Hypothetical protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (559 aa)
leuCPutative isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (474 aa)
leuDIsopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (245 aa)
dapA-2Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (299 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (295 aa)
AEW97648.1Aminotransferase. (273 aa)
Your Current Organism:
Streptomyces cattleya
NCBI taxonomy Id: 1003195
Other names: S. cattleya NRRL 8057 = DSM 46488, Streptomyces cattleya DSM 46488, Streptomyces cattleya DSM 46488 = NRRL 8057, Streptomyces cattleya JCM 4925, Streptomyces cattleya NBRC 14057, Streptomyces cattleya NRRL 8057, Streptomyces cattleya NRRL 8057 = DSM 46488
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.