node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aldh1a2 | Cyp1a2 | ENSMAUP00000017209 | ENSMAUP00000007198 | Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | 0.847 |
Aldh1a2 | Cyp26a1 | ENSMAUP00000017209 | ENSMAUP00000002954 | Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. | Cytochrome P450 26A1; Belongs to the cytochrome P450 family. | 0.930 |
Aldh1a2 | Cyp26b1 | ENSMAUP00000017209 | ENSMAUP00000002110 | Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. | Cytochrome P450 26B1; Belongs to the cytochrome P450 family. | 0.923 |
Aldh1a2 | Cyp26c1 | ENSMAUP00000017209 | ENSMAUP00000025122 | Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. | Cytochrome P450 26C1; Belongs to the cytochrome P450 family. | 0.903 |
Aldh1a2 | Cyp2c70 | ENSMAUP00000017209 | ENSMAUP00000004415 | Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. | Cytochrome P450 2C70-like; Belongs to the cytochrome P450 family. | 0.845 |
Aldh1a2 | Cyp2s1 | ENSMAUP00000017209 | ENSMAUP00000019491 | Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. | Cytochrome P450 2S1 isoform X1; Belongs to the cytochrome P450 family. | 0.845 |
Aldh1a2 | Cyp3a13 | ENSMAUP00000017209 | ENSMAUP00000008552 | Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. | Cytochrome P450 3A9. | 0.857 |
Aldh1a2 | LOC101836914 | ENSMAUP00000017209 | ENSMAUP00000013162 | Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. | Cytochrome P450 3A31; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.857 |
Aldh1a2 | Ugt2a3 | ENSMAUP00000017209 | ENSMAUP00000001751 | Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.798 |
Aldh1a2 | Ugt2b1 | ENSMAUP00000017209 | ENSMAUP00000022597 | Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. | UDP-glucuronosyltransferase 2B1; Belongs to the UDP-glycosyltransferase family. | 0.845 |
Cyp1a2 | Aldh1a2 | ENSMAUP00000007198 | ENSMAUP00000017209 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. | 0.847 |
Cyp1a2 | Cyp26a1 | ENSMAUP00000007198 | ENSMAUP00000002954 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Cytochrome P450 26A1; Belongs to the cytochrome P450 family. | 0.919 |
Cyp1a2 | Cyp26b1 | ENSMAUP00000007198 | ENSMAUP00000002110 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Cytochrome P450 26B1; Belongs to the cytochrome P450 family. | 0.910 |
Cyp1a2 | Cyp26c1 | ENSMAUP00000007198 | ENSMAUP00000025122 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Cytochrome P450 26C1; Belongs to the cytochrome P450 family. | 0.908 |
Cyp1a2 | Cyp2c70 | ENSMAUP00000007198 | ENSMAUP00000004415 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Cytochrome P450 2C70-like; Belongs to the cytochrome P450 family. | 0.915 |
Cyp1a2 | Cyp2s1 | ENSMAUP00000007198 | ENSMAUP00000019491 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Cytochrome P450 2S1 isoform X1; Belongs to the cytochrome P450 family. | 0.863 |
Cyp1a2 | Cyp3a13 | ENSMAUP00000007198 | ENSMAUP00000008552 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Cytochrome P450 3A9. | 0.907 |
Cyp1a2 | LOC101836914 | ENSMAUP00000007198 | ENSMAUP00000013162 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | Cytochrome P450 3A31; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.925 |
Cyp1a2 | Ugt2a3 | ENSMAUP00000007198 | ENSMAUP00000001751 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.927 |
Cyp1a2 | Ugt2b1 | ENSMAUP00000007198 | ENSMAUP00000022597 | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | UDP-glucuronosyltransferase 2B1; Belongs to the UDP-glycosyltransferase family. | 0.941 |