STRINGSTRING
Tlr1 Tlr1 Tradd Tradd Nod1 Nod1 ENSMAUP00000000511 ENSMAUP00000000511 Ssh1 Ssh1 Gm36210 Gm36210 Ripk1 Ripk1 Tab3 Tab3 Cfl2 Cfl2 Ptprr Ptprr Dusp6 Dusp6 Traf2 Traf2 Tlr2 Tlr2 Tollip Tollip Traf5 Traf5 Cyld Cyld Dusp27 Dusp27 Sla Sla Cdc14b Cdc14b Irak1 Irak1 Stk38l Stk38l Tnfrsf1a Tnfrsf1a Ly86 Ly86 Plekhg6 Plekhg6 Map2k7 Map2k7 Sharpin Sharpin Zranb1 Zranb1 Nod2 Nod2 LOC106023140 LOC106023140 Tlr8 Tlr8 Dstn Dstn Rnf151 Rnf151 Limk2 Limk2 Dusp2 Dusp2 Mapkapk2 Mapkapk2 Traf6 Traf6 Mapk8ip1 Mapk8ip1 Otud7a Otud7a Map3k15 Map3k15 Mapk8 Mapk8 ENSMAUP00000004829 ENSMAUP00000004829 Map3k14 Map3k14 ENSMAUP00000005106 ENSMAUP00000005106 Pdzrn3 Pdzrn3 Map3k1 Map3k1 Tesk2 Tesk2 Snrk Snrk Tlr6 Tlr6 Tnip3 Tnip3 Faslg Faslg Nsmaf Nsmaf Bag4 Bag4 Ikbke Ikbke Ikbkg Ikbkg Ripk3 Ripk3 Fas Fas Ripk2 Ripk2 Plk2 Plk2 Map4k3 Map4k3 Plekhg5 Plekhg5 Traf4 Traf4 Myd88 Myd88 Tnip1 Tnip1 Dusp16 Dusp16 Map3k19 Map3k19 Nhlrc2 Nhlrc2 Cdc14a Cdc14a Mapk8ip2 Mapk8ip2 Mapk8ip3 Mapk8ip3 Tab2 Tab2 Dnase1l3 Dnase1l3 Rtl4 Rtl4 LOC101828971 LOC101828971 Dusp5 Dusp5 Pp2d1 Pp2d1 Dusp23 Dusp23 Cd180 Cd180 Tank Tank Peli1 Peli1 Tm2d3 Tm2d3 Ern2 Ern2 Znf32 Znf32 Limk1 Limk1 Tmc5 Tmc5 Tnfsf10 Tnfsf10 Ptprq Ptprq Map3k10 Map3k10 Map4k2 Map4k2 LOC106021788 LOC106021788 Vrk3 Vrk3 Map2k5 Map2k5 Map3k11 Map3k11 Peli2 Peli2 Irak4 Irak4 Peli3 Peli3 Styx Styx ENSMAUP00000016945 ENSMAUP00000016945 Mapk14 Mapk14 Tlr5 Tlr5 Rbck1 Rbck1 Tirap Tirap Ssh3 Ssh3 Dusp10 Dusp10 Dusp26 Dusp26 Map3k7 Map3k7 Otud7b Otud7b Mapk10 Mapk10 Ptpn5 Ptpn5 Tlr4 Tlr4 Mapk1 Mapk1 Mapk13 Mapk13 Cd14 Cd14 Mapk9 Mapk9 Lrrk1 Lrrk1 Ripk4 Ripk4 Map3k6 Map3k6 Ly96 Ly96 Tlr9 Tlr9 LOC101827806 LOC101827806 Optn Optn Fadd Fadd Dusp19 Dusp19 Tlr7 Tlr7 LOC101822968 LOC101822968 Ticam2 Ticam2 Map3k7cl Map3k7cl Cfl1 Cfl1 Rnf31 Rnf31 Trafd1 Trafd1 Map3k5 Map3k5 Birc2 Birc2 LOC101837855 LOC101837855 Mlkl Mlkl Fra10ac1 Fra10ac1 Traf1 Traf1 Dusp4 Dusp4 Unc93b1 Unc93b1 Ticam1 Ticam1 Casp8 Casp8 Wnk2 Wnk2 Nrde2 Nrde2 Nlrp14 Nlrp14 Irak3 Irak3 Dusp8 Dusp8 ENSMAUP00000021256 ENSMAUP00000021256 Tlr11 Tlr11 Mob2 Mob2 Ptpn7 Ptpn7 Tnfaip3 Tnfaip3 Dab2ip Dab2ip Cflar Cflar Stk38 Stk38 Map4k1 Map4k1 Map3k9 Map3k9 LOC106020873 LOC106020873 Map3k2 Map3k2 Myocd Myocd Map3k21 Map3k21 Lrrc56 Lrrc56 Dusp3 Dusp3 Map2k3 Map2k3 Unc93a Unc93a Dusp7 Dusp7 Map4k5 Map4k5 Ssh2 Ssh2 Pdzrn4 Pdzrn4 Spata2 Spata2 Cdca7 Cdca7 Dusp9 Dusp9 Map2k6 Map2k6 Tlr3 Tlr3 Fam184a Fam184a Map3k20 Map3k20 Dnase1l2 Dnase1l2 Slc12a9 Slc12a9 Map2k4 Map2k4 Traf3 Traf3 Tbc1d2 Tbc1d2 Map3k3 Map3k3 Tab1 Tab1 Mapk12 Mapk12 Sost Sost
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Tlr1Toll-like receptor 1; Belongs to the Toll-like receptor family. (794 aa)
TraddTumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2. (310 aa)
Nod1Nucleotide-binding oligomerization domain-containing protein 1 isoform X1. (953 aa)
ENSMAUP00000000511annotation not available (91 aa)
Ssh1Protein phosphatase Slingshot homolog 1 isoform X1. (1036 aa)
Gm36210Predicted gene, 36210. (232 aa)
Ripk1Receptor-interacting serine/threonine-protein kinase 1. (658 aa)
Tab3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X2. (715 aa)
Cfl2Cofilin 2. (105 aa)
PtprrReceptor-type tyrosine-protein phosphatase R. (645 aa)
Dusp6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (379 aa)
Traf2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
Tlr2Toll-like receptor. (784 aa)
TollipToll-interacting protein. (274 aa)
Traf5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (550 aa)
CyldUbiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family. (956 aa)
Dusp27Inactive dual specificity phosphatase 27; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (1137 aa)
SlaSrc-like-adapter. (298 aa)
Cdc14bDual specificity protein phosphatase CDC14B. (481 aa)
Irak1Interleukin-1 receptor-associated kinase 1 isoform X2. (747 aa)
Stk38lNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (464 aa)
Tnfrsf1aTumor necrosis factor receptor superfamily member 1A. (468 aa)
Ly86Lymphocyte antigen 86. (160 aa)
Plekhg6Pleckstrin homology domain-containing family G member 6. (540 aa)
Map2k7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (520 aa)
SharpinSharpin. (154 aa)
Zranb1Ubiquitin thioesterase ZRANB1. (690 aa)
Nod2Nucleotide-binding oligomerization domain-containing protein 2 isoform X2. (1023 aa)
LOC106023140LIM domain kinase 1-like. (73 aa)
Tlr8Toll-like receptor 8 isoform X1; Belongs to the Toll-like receptor family. (1028 aa)
DstnDestrin; Belongs to the actin-binding proteins ADF family. (165 aa)
Rnf151RING finger protein 151. (239 aa)
Limk2LIM domain kinase 2 isoform X1. (638 aa)
Dusp2Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (318 aa)
Mapkapk2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (386 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
Mapk8ip1C-Jun-amino-terminal kinase-interacting protein 1 isoform X1. (698 aa)
Otud7aOTU domain-containing protein 7A. (859 aa)
Map3k15Mitogen-activated protein kinase kinase kinase 15. (1197 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
ENSMAUP00000004829annotation not available (162 aa)
Map3k14Mitogen-activated protein kinase kinase kinase 14. (941 aa)
ENSMAUP00000005106annotation not available (174 aa)
Pdzrn3E3 ubiquitin-protein ligase PDZRN3 isoform X1. (1064 aa)
Map3k1Mitogen-activated protein kinase kinase kinase 1. (1475 aa)
Tesk2Dual specificity testis-specific protein kinase 2. (554 aa)
SnrkSNF-related serine/threonine-protein kinase. (743 aa)
Tlr6Toll-like receptor 6; Belongs to the Toll-like receptor family. (789 aa)
Tnip3TNFAIP3-interacting protein 3 isoform X1. (278 aa)
FaslgTumor necrosis factor ligand superfamily member 6 isoform X1; Belongs to the tumor necrosis factor family. (279 aa)
NsmafProtein FAN. (876 aa)
Bag4BAG family molecular chaperone regulator 4 isoform X2. (455 aa)
IkbkeInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (715 aa)
IkbkgNF-kappa-B essential modulator isoform X1. (412 aa)
Ripk3Receptor-interacting serine/threonine-protein kinase 3 isoform X1; Belongs to the protein kinase superfamily. (483 aa)
FasTumor necrosis factor receptor superfamily member 6 isoform X1. (323 aa)
Ripk2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (325 aa)
Plk2Serine/threonine-protein kinase PLK. (682 aa)
Map4k3Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (866 aa)
Plekhg5Pleckstrin homology domain-containing family G member 5. (1054 aa)
Traf4TNF receptor-associated factor. (470 aa)
Myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
Tnip1TNFAIP3-interacting protein 1 isoform X2. (654 aa)
Dusp16Dual specificity protein phosphatase 16. (338 aa)
Map3k19Mitogen-activated protein kinase kinase kinase 19. (1463 aa)
Nhlrc2NHL repeat containing 2. (489 aa)
Cdc14aDual specificity protein phosphatase CDC14A isoform X1. (625 aa)
Mapk8ip2C-Jun-amino-terminal kinase-interacting protein 2. (830 aa)
Mapk8ip3C-Jun-amino-terminal kinase-interacting protein 3. (1337 aa)
Tab2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1. (693 aa)
Dnase1l3Deoxyribonuclease; Belongs to the DNase I family. (313 aa)
Rtl4Zinc finger CCHC domain-containing protein 16. (304 aa)
LOC101828971Integrin-linked kinase-associated serine/threonine phosphatase 2C. (137 aa)
Dusp5Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (384 aa)
Pp2d1Protein phosphatase 2C-like domain-containing protein 1. (613 aa)
Dusp23Dual specificity protein phosphatase 23. (150 aa)
Cd180CD180 antigen. (631 aa)
TankTRAF family member-associated NF-kappa-B activator isoform X2. (443 aa)
Peli1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
Tm2d3TM2 domain-containing protein 3 isoform X2. (251 aa)
Ern2Serine/threonine-protein kinase/endoribonuclease IRE2. (901 aa)
Znf32Zinc finger protein 32 isoform X1. (272 aa)
Limk1LIM domain kinase 1. (584 aa)
Tmc5Transmembrane channel-like protein. (974 aa)
Tnfsf10Tumor necrosis factor ligand superfamily member. (289 aa)
PtprqPhosphatidylinositol phosphatase PTPRQ. (2324 aa)
Map3k10Mitogen-activated protein kinase kinase kinase. (291 aa)
Map4k2Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (790 aa)
LOC106021788Histone-lysine N-methyltransferase SMYD3-like. (165 aa)
Vrk3Inactive serine/threonine-protein kinase VRK3 isoform X1. (450 aa)
Map2k5Dual specificity mitogen-activated protein kinase kinase 5 isoform X1; Belongs to the protein kinase superfamily. (448 aa)
Map3k11Mitogen-activated protein kinase kinase kinase 11. (265 aa)
Peli2E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (419 aa)
Irak4Interleukin-1 receptor-associated kinase 4. (461 aa)
Peli3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (445 aa)
StyxSerine/threonine/tyrosine-interacting protein. (223 aa)
ENSMAUP00000016945annotation not available (190 aa)
Mapk14Mitogen-activated protein kinase. (360 aa)
Tlr5Toll-like receptor 5; Belongs to the Toll-like receptor family. (858 aa)
Rbck1ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X2. (503 aa)
TirapToll/interleukin-1 receptor domain-containing adapter protein isoform X2. (245 aa)
Ssh3Protein phosphatase Slingshot homolog 3 isoform X1. (651 aa)
Dusp10Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
Dusp26Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (211 aa)
Map3k7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (497 aa)
Otud7bOTU domain-containing protein 7B. (596 aa)
Mapk10Mitogen-activated protein kinase 10. (252 aa)
Ptpn5Tyrosine-protein phosphatase non-receptor type 5. (541 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa)
Mapk13Mitogen-activated protein kinase. (366 aa)
Cd14Monocyte differentiation antigen CD14. (370 aa)
Mapk9Mitogen-activated protein kinase. (423 aa)
Lrrk1Leucine-rich repeat serine/threonine-protein kinase 1. (1818 aa)
Ripk4Receptor-interacting serine/threonine-protein kinase 4. (786 aa)
Map3k6Mitogen-activated protein kinase kinase kinase 6 isoform X1. (1289 aa)
Ly96Lymphocyte antigen 96. (74 aa)
Tlr9Toll-like receptor 9. (1030 aa)
LOC101827806Toll-like receptor 13. (953 aa)
OptnOptineurin. (513 aa)
FaddFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
Dusp19Dual specificity protein phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (141 aa)
Tlr7Toll-like receptor 7 isoform X1; Belongs to the Toll-like receptor family. (1050 aa)
LOC101822968Tumor necrosis factor receptor superfamily member 22-like isoform X1. (108 aa)
Ticam2TIR domain-containing adapter molecule 2. (233 aa)
Map3k7clMAP3K7 C-terminal-like protein. (142 aa)
Cfl1Cofilin-1; Belongs to the actin-binding proteins ADF family. (166 aa)
Rnf31E3 ubiquitin-protein ligase RNF31. (1065 aa)
Trafd1TRAF-type zinc finger domain-containing protein 1. (44 aa)
Map3k5Mitogen-activated protein kinase kinase kinase 5 isoform X2. (1381 aa)
Birc2Baculoviral IAP repeat-containing protein 2. (592 aa)
LOC101837855C-Jun-amino-terminal kinase-interacting protein 4-like. (466 aa)
MlklMixed lineage kinase domain-like protein. (439 aa)
Fra10ac1Protein FRA10AC1 homolog. (170 aa)
Traf1TNF receptor-associated factor. (410 aa)
Dusp4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (385 aa)
Unc93b1LOW QUALITY PROTEIN: protein unc-93 homolog B1. (603 aa)
Ticam1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (733 aa)
Casp8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (481 aa)
Wnk2Serine/threonine-protein kinase WNK2 isoform X1. (2213 aa)
Nrde2Protein NRDE2 homolog. (1167 aa)
Nlrp14NACHT, LRR and PYD domains-containing protein 14 isoform X1. (996 aa)
Irak3Interleukin-1 receptor-associated kinase 3. (382 aa)
Dusp8Dual specificity protein phosphatase 8. (628 aa)
ENSMAUP00000021256annotation not available (277 aa)
Tlr11Toll-like receptor 11. (929 aa)
Mob2MOB kinase activator 2. (266 aa)
Ptpn7Tyrosine-protein phosphatase non-receptor type 7 isoform X1. (338 aa)
Tnfaip3Tumor necrosis factor alpha-induced protein 3 isoform X1. (776 aa)
Dab2ipDisabled homolog 2-interacting protein isoform X2. (1191 aa)
CflarCASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (219 aa)
Stk38Serine/threonine kinase 38. (204 aa)
Map4k1Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (743 aa)
Map3k9Mitogen-activated protein kinase kinase kinase 9 isoform X1. (1041 aa)
LOC106020873Tumor necrosis factor receptor superfamily member 26-like. (188 aa)
Map3k2Mitogen-activated protein kinase kinase kinase 2 isoform X1. (619 aa)
MyocdMyocardin. (931 aa)
Map3k21Mitogen-activated protein kinase kinase kinase. (1002 aa)
Lrrc56Leucine-rich repeat-containing protein 56 isoform X1. (552 aa)
Dusp3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (210 aa)
Map2k3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
Unc93aProtein unc-93 homolog A. (459 aa)
Dusp7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
Map4k5Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (833 aa)
Ssh2Protein phosphatase Slingshot homolog 2 isoform X1. (1405 aa)
Pdzrn4PDZ domain-containing RING finger protein 4 isoform X2. (775 aa)
Spata2Spermatogenesis-associated protein 2. (521 aa)
Cdca7Cell division cycle-associated protein 7 isoform X2. (371 aa)
Dusp9Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (384 aa)
Map2k6Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (334 aa)
Tlr3Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
Fam184aProtein FAM184A isoform X2. (510 aa)
Map3k20Mitogen-activated protein kinase kinase kinase 20. (762 aa)
Dnase1l2Deoxyribonuclease; Belongs to the DNase I family. (278 aa)
Slc12a9Solute carrier family 12 member 9. (818 aa)
Map2k4Dual specificity mitogen-activated protein kinase kinase 4 isoform X2; Belongs to the protein kinase superfamily. (131 aa)
Traf3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
Tbc1d2TBC1 domain family member 2A. (794 aa)
Map3k3Mitogen-activated protein kinase kinase kinase 3. (550 aa)
Tab1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (254 aa)
Mapk12Mitogen-activated protein kinase. (367 aa)
SostSclerostin. (213 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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