STRINGSTRING
Edn1 Edn1 Map3k4 Map3k4 Nod2 Nod2 Hacd3 Hacd3 Tgfb1 Tgfb1 Nrk Nrk Map3k8 Map3k8 Map2k7 Map2k7 Ret Ret LOC101842741 LOC101842741 Ccr3 Ccr3 Stradb Stradb Mapk6 Mapk6 Irak1 Irak1 Pea15 Pea15 Ror2 Ror2 Nphs1 Nphs1 Ppm1l Ppm1l Scg2 Scg2 Ywhaz Ywhaz Ar Ar Tnfsf11 Tnfsf11 Pafah1b1 Pafah1b1 Mbp Mbp Pbk Pbk Cd36 Cd36 Ripk1 Ripk1 Fgf18 Fgf18 Spry2 Spry2 Setx Setx Nod1 Nod1 Prkce Prkce Hesx1 Hesx1 Mt3 Mt3 Shank3 Shank3 Rhbdd3 Rhbdd3 Mapkapk2 Mapkapk2 Traf6 Traf6 Mapk8ip1 Mapk8ip1 Map3k15 Map3k15 Mapk8 Mapk8 ENSMAUP00000004933 ENSMAUP00000004933 Map3k14 Map3k14 Pabpn1 Pabpn1 Map3k1 Map3k1 Myc Myc Ercc6 Ercc6 Iqgap3 Iqgap3 Igfbp4 Igfbp4 Fgf13 Fgf13 Pak3 Pak3 Ankrd10 Ankrd10 Ripk2 Ripk2 Fgf23 Fgf23 Btn2a2 Btn2a2 Smad4 Smad4 Map4k3 Map4k3 Trib1 Trib1 Map4k4 Map4k4 Araf Araf Myd88 Myd88 Ywhae Ywhae Nenf Nenf Mapk8ip2 Mapk8ip2 Mapk8ip3 Mapk8ip3 Taok2 Taok2 Brap Brap Map2k1 Map2k1 Map2k2 Map2k2 LOC101843307 LOC101843307 Map3k13 Map3k13 Fgf10 Fgf10 Mapk3 Mapk3 Rapgef1 Rapgef1 LOC101825816 LOC101825816 Fgfr3 Fgfr3 Igfbp3 Igfbp3 Mapk7 Mapk7 Gadd45a Gadd45a ENSMAUP00000013047 ENSMAUP00000013047 Il18 Il18 Itpkb Itpkb Lrrk2 Lrrk2 Ptger4 Ptger4 Tnf Tnf Men1 Men1 Mef2a Mef2a Wnt5a Wnt5a Map3k10 Map3k10 Fgf2 Fgf2 Map4k2 Map4k2 Mef2c Mef2c Htr2b Htr2b Bank1 Bank1 Map2k5 Map2k5 Raf1 Raf1 Mapk15 Mapk15 Egf Egf Ccl11 Ccl11 Map3k11 Map3k11 Itgav Itgav Irak4 Irak4 Mapk14 Mapk14 Braf Braf Kdr Kdr Fgf8 Fgf8 Ctsh Ctsh Spry1 Spry1 Stk3 Stk3 Dusp10 Dusp10 Nox1 Nox1 Mos Mos Nr2c2 Nr2c2 Map3k7 Map3k7 Mapk10 Mapk10 Tlr4 Tlr4 Mapk1 Mapk1 Mapk4 Mapk4 Mapk13 Mapk13 Tmem248 Tmem248 Tbc1d10c Tbc1d10c Mapk9 Mapk9 Nlk Nlk Map3k6 Map3k6 Il1b Il1b C1ql4 C1ql4 Flcn Flcn Sbk2 Sbk2 Dusp19 Dusp19 Tlr7 Tlr7 Plvap Plvap Cckbr Cckbr Nfkb1 Nfkb1 Map3k5 Map3k5 Taok3 Taok3 Cdc42ep5 Cdc42ep5 Atf2 Atf2 Gps2 Gps2 Mapk11 Mapk11 Smad3 Smad3 Nrg1 Nrg1 Mapk12 Mapk12 LOC101839104 LOC101839104 Sorbs3 Sorbs3 Nf1 Nf1 Map2k4 Map2k4 Trf Trf Map3k20 Map3k20 Tlr3 Tlr3 Zfp36 Zfp36 Ccl3 Ccl3 Map2k6 Map2k6 Tnik Tnik Igf1 Igf1 Map4k5 Map4k5 Grb10 Grb10 Ccl2 Ccl2 Oxtr Oxtr Sox9 Sox9 Card9 Card9 Map2k3 Map2k3 Atf7 Atf7 Map3k21 Map3k21 Map3k2 Map3k2 Smad1 Smad1 Zfp36l1 Zfp36l1 Map3k9 Map3k9 Map4k1 Map4k1 Mink1 Mink1 Taok1 Taok1 Daxx Daxx Map3k12 Map3k12 Adra1a Adra1a Cav3 Cav3 Pou4f2 Pou4f2 Hsf1 Hsf1 Ptk2b Ptk2b Agt Agt
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Edn1Endothelin-1. (202 aa)
Map3k4Mitogen-activated protein kinase kinase kinase 4 isoform X2. (578 aa)
Nod2Nucleotide-binding oligomerization domain-containing protein 2 isoform X2. (1023 aa)
Hacd3Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (362 aa)
Tgfb1Transforming growth factor beta-1. (286 aa)
NrkNik-related protein kinase. (357 aa)
Map3k8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
Map2k7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (520 aa)
RetProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
LOC101842741Kinesin-related protein 4-like. (686 aa)
Ccr3C-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (359 aa)
StradbSTE20-related kinase adapter protein beta. (280 aa)
Mapk6Mitogen-activated protein kinase 6. (722 aa)
Irak1Interleukin-1 receptor-associated kinase 1 isoform X2. (747 aa)
Pea15Astrocytic phosphoprotein PEA-15. (130 aa)
Ror2Tyrosine-protein kinase transmembrane receptor ROR2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (922 aa)
Nphs1Nephrin isoform X1. (1256 aa)
Ppm1lProtein phosphatase 1L. (360 aa)
Scg2Secretogranin-2 isoform X1. (620 aa)
Ywhaz14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (212 aa)
ArAndrogen receptor. (900 aa)
Tnfsf11Tumor necrosis factor ligand superfamily member. (318 aa)
Pafah1b1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (349 aa)
MbpMyelin basic protein isoform X1. (195 aa)
PbkLymphokine-activated killer T-cell-originated protein kinase. (322 aa)
Cd36Platelet glycoprotein 4; Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor- ligand complexes. The depende [...] (472 aa)
Ripk1Receptor-interacting serine/threonine-protein kinase 1. (658 aa)
Fgf18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Spry2Protein sprouty homolog 2. (320 aa)
SetxProbable helicase senataxin. (2604 aa)
Nod1Nucleotide-binding oligomerization domain-containing protein 1 isoform X1. (953 aa)
PrkceProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (623 aa)
Hesx1Homeobox expressed in ES cells 1. (185 aa)
Mt3Metallothionein 3. (68 aa)
Shank3SH3 and multiple ankyrin repeat domains protein 3. (1710 aa)
Rhbdd3Rhomboid domain-containing protein 3. (385 aa)
Mapkapk2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (386 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
Mapk8ip1C-Jun-amino-terminal kinase-interacting protein 1 isoform X1. (698 aa)
Map3k15Mitogen-activated protein kinase kinase kinase 15. (1197 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
ENSMAUP00000004933annotation not available (593 aa)
Map3k14Mitogen-activated protein kinase kinase kinase 14. (941 aa)
Pabpn1Polyadenylate-binding protein 2. (333 aa)
Map3k1Mitogen-activated protein kinase kinase kinase 1. (1475 aa)
MycMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
Ercc6DNA excision repair protein ERCC-6. (1236 aa)
Iqgap3Ras GTPase-activating-like protein IQGAP3 isoform X2. (1632 aa)
Igfbp4Insulin-like growth factor-binding protein 4. (254 aa)
Fgf13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
Pak3Non-specific serine/threonine protein kinase. (559 aa)
Ankrd10Ankyrin repeat domain-containing protein 10 isoform X1. (413 aa)
Ripk2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (325 aa)
Fgf23Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
Btn2a2Butyrophilin subfamily 2 member A2. (514 aa)
Smad4Mothers against decapentaplegic homolog. (552 aa)
Map4k3Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (866 aa)
Trib1Tribbles homolog 1 isoform X1. (373 aa)
Map4k4Mitogen-activated protein kinase kinase kinase kinase 4 isoform X13. (1289 aa)
ArafSerine/threonine-protein kinase A-Raf isoform X2. (604 aa)
Myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
Ywhae14-3-3 protein epsilon isoform X1; Belongs to the 14-3-3 family. (255 aa)
NenfNeudesin; Belongs to the cytochrome b5 family. (171 aa)
Mapk8ip2C-Jun-amino-terminal kinase-interacting protein 2. (830 aa)
Mapk8ip3C-Jun-amino-terminal kinase-interacting protein 3. (1337 aa)
Taok2Serine/threonine-protein kinase TAO2 isoform X1. (1240 aa)
BrapBRCA1-associated protein. (589 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
LOC101843307LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 26-like. (520 aa)
Map3k13Mitogen-activated protein kinase kinase kinase 13. (560 aa)
Fgf10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
Mapk3Mitogen-activated protein kinase. (380 aa)
Rapgef1Rap guanine nucleotide exchange factor 1. (1202 aa)
LOC101825816STE20-related kinase adapter protein beta. (172 aa)
Fgfr3Fibroblast growth factor receptor. (802 aa)
Igfbp3Insulin-like growth factor-binding protein 3. (292 aa)
Mapk7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (806 aa)
Gadd45aGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
ENSMAUP00000013047annotation not available (67 aa)
Il18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (197 aa)
ItpkbKinase; Belongs to the inositol phosphokinase (IPK) family. (941 aa)
Lrrk2Leucine-rich repeat serine/threonine-protein kinase 2. (2527 aa)
Ptger4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (488 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
Men1Menin isoform X2. (610 aa)
Mef2aMyocyte-specific enhancer factor 2A isoform X1. (274 aa)
Wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
Map3k10Mitogen-activated protein kinase kinase kinase. (291 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
Map4k2Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (790 aa)
Mef2cMyocyte-specific enhancer factor 2C isoform X4. (483 aa)
Htr2b5-hydroxytryptamine receptor 2B. (480 aa)
Bank1B-cell scaffold protein with ankyrin repeats. (787 aa)
Map2k5Dual specificity mitogen-activated protein kinase kinase 5 isoform X1; Belongs to the protein kinase superfamily. (448 aa)
Raf1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
Mapk15Mitogen-activated protein kinase. (539 aa)
EgfPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (254 aa)
Ccl11C-C motif chemokine. (97 aa)
Map3k11Mitogen-activated protein kinase kinase kinase 11. (265 aa)
ItgavIntegrin alpha-V isoform X1; Belongs to the integrin alpha chain family. (1045 aa)
Irak4Interleukin-1 receptor-associated kinase 4. (461 aa)
Mapk14Mitogen-activated protein kinase. (360 aa)
BrafSerine/threonine-protein kinase B-raf. (710 aa)
KdrVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1347 aa)
Fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
CtshPro-cathepsin H; Belongs to the peptidase C1 family. (333 aa)
Spry1Protein sprouty homolog 1. (313 aa)
Stk3Serine/threonine-protein kinase 3. (468 aa)
Dusp10Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
Nox1NADPH oxidase 1. (587 aa)
MosProto-oncogene serine/threonine-protein kinase mos; Belongs to the protein kinase superfamily. (357 aa)
Nr2c2Nuclear receptor subfamily 2, group C, member 2. (450 aa)
Map3k7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (497 aa)
Mapk10Mitogen-activated protein kinase 10. (252 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa)
Mapk4Mitogen-activated protein kinase 4. (583 aa)
Mapk13Mitogen-activated protein kinase. (366 aa)
Tmem248Transmembrane protein 248 isoform X2. (314 aa)
Tbc1d10cCarabin isoform X1. (446 aa)
Mapk9Mitogen-activated protein kinase. (423 aa)
NlkMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
Map3k6Mitogen-activated protein kinase kinase kinase 6 isoform X1. (1289 aa)
Il1bMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
C1ql4Complement C1q-like protein 4. (238 aa)
FlcnFolliculin. (466 aa)
Sbk2Serine/threonine-protein kinase SBK2; Belongs to the protein kinase superfamily. (382 aa)
Dusp19Dual specificity protein phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (141 aa)
Tlr7Toll-like receptor 7 isoform X1; Belongs to the Toll-like receptor family. (1050 aa)
PlvapPlasmalemma vesicle-associated protein. (440 aa)
CckbrGastrin/cholecystokinin type B receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (451 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit isoform X1. (970 aa)
Map3k5Mitogen-activated protein kinase kinase kinase 5 isoform X2. (1381 aa)
Taok3Serine/threonine-protein kinase TAO3. (898 aa)
Cdc42ep5Cdc42 effector protein 5. (153 aa)
Atf2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (480 aa)
Gps2G protein pathway suppressor 2 isoform X2. (327 aa)
Mapk11Mitogen-activated protein kinase. (355 aa)
Smad3Mothers against decapentaplegic homolog. (425 aa)
Nrg1Pro-neuregulin-1, membrane-bound isoform. (655 aa)
Mapk12Mitogen-activated protein kinase. (367 aa)
LOC101839104Insulin-like growth factor-binding protein 3. (177 aa)
Sorbs3Vinexin isoform X1. (735 aa)
Nf1Neurofibromin. (2400 aa)
Map2k4Dual specificity mitogen-activated protein kinase kinase 4 isoform X2; Belongs to the protein kinase superfamily. (131 aa)
TrfSerotransferrin; Belongs to the transferrin family. (702 aa)
Map3k20Mitogen-activated protein kinase kinase kinase 20. (762 aa)
Tlr3Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
Zfp36mRNA decay activator protein ZFP36. (311 aa)
Ccl3C-C motif chemokine. (98 aa)
Map2k6Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (334 aa)
TnikTRAF2 and NCK-interacting protein kinase. (538 aa)
Igf1Insulin-like growth factor 1. (153 aa)
Map4k5Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (833 aa)
Grb10Growth factor receptor-bound protein 10 isoform X2. (584 aa)
Ccl2C-C motif chemokine. (143 aa)
OxtrOxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (390 aa)
Sox9Transcription factor SOX-9. (507 aa)
Card9Caspase recruitment domain-containing protein 9 isoform X2. (537 aa)
Map2k3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
Atf7Cyclic AMP-dependent transcription factor ATF-7. (385 aa)
Map3k21Mitogen-activated protein kinase kinase kinase. (1002 aa)
Map3k2Mitogen-activated protein kinase kinase kinase 2 isoform X1. (619 aa)
Smad1Mothers against decapentaplegic homolog. (465 aa)
Zfp36l1mRNA decay activator protein ZFP36L1. (338 aa)
Map3k9Mitogen-activated protein kinase kinase kinase 9 isoform X1. (1041 aa)
Map4k1Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (743 aa)
Mink1Misshapen-like kinase 1 isoform X7. (1319 aa)
Taok1LOW QUALITY PROTEIN: serine/threonine-protein kinase TAO1. (1001 aa)
DaxxDeath domain-associated protein 6 isoform X1. (131 aa)
Map3k12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (877 aa)
Adra1aalpha-1A adrenergic receptor isoform X1. (465 aa)
Cav3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
Pou4f2POU domain protein. (408 aa)
Hsf1Heat shock factor protein 1. (423 aa)
Ptk2bProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
AgtAngiotensinogen; Belongs to the serpin family. (482 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
Server load: low (32%) [HD]