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Cyp26b1 Cyp26b1 Ch25h Ch25h LOC101844487 LOC101844487 LOC101831088 LOC101831088 LOC101825889 LOC101825889 Tyr Tyr Ccdc160 Ccdc160 Hmox1 Hmox1 Micalcl Micalcl Kmo Kmo LOC101833813 LOC101833813 Coq7 Coq7 Agmo Agmo ENSMAUP00000018841 ENSMAUP00000018841 Nos3 Nos3 Nos1 Nos1 Cmah Cmah Akr1c18 Akr1c18 Tti2 Tti2 Nos2 Nos2 Ptgis Ptgis LOC101844221 LOC101844221 LOC101844759 LOC101844759 Akr1c19 Akr1c19 Cyp17a1 Cyp17a1 LOC101826326 LOC101826326 Cyp2u1 Cyp2u1 Cyp39a1 Cyp39a1 Cyp19a1 Cyp19a1 LOC101826047 LOC101826047 Cyp2ab1 Cyp2ab1 Miox Miox Cyp46a1 Cyp46a1 Pam Pam LOC101836914 LOC101836914 Cyp24a1 Cyp24a1 Gm4847 Gm4847 Dbh Dbh Cyp1b1 Cyp1b1 Cyp1a1 Cyp1a1 LOC101823339 LOC101823339 LOC101827747 LOC101827747 LOC101838830 LOC101838830 Cyp27a1 Cyp27a1 Msmo1 Msmo1 Tph2 Tph2 Cyp4x1 Cyp4x1 Cyp4b1 Cyp4b1 Cyp7a1 Cyp7a1 LOC101831958 LOC101831958 Akr1d1 Akr1d1 Coq6 Coq6 Mical3 Mical3 Cyp4a30b Cyp4a30b Fmo9 Fmo9 Hmox2 Hmox2 Cyp3a13 Cyp3a13 Fmo4 Fmo4 Pcbd1 Pcbd1 LOC101830103 LOC101830103 Cyp4f13 Cyp4f13 Tbxas1 Tbxas1 Cyp1a2 Cyp1a2 ENSMAUP00000007047 ENSMAUP00000007047 Cyp4f14 Cyp4f14 LOC101841191 LOC101841191 Mical2 Mical2 Ccndbp1 Ccndbp1 Dohh Dohh Cyp27b1 Cyp27b1 Bco1 Bco1 Fmo2 Fmo2 Mical1 Mical1 LOC101844281 LOC101844281 LOC101832144 LOC101832144 Cyp2c70 Cyp2c70 Cyp8b1 Cyp8b1 Sqle Sqle LOC101843587 LOC101843587 Fmo3 Fmo3 LOC101830700 LOC101830700 Saal1 Saal1 Cyp2w1 Cyp2w1 LOC101829291 LOC101829291 ENSMAUP00000024468 ENSMAUP00000024468 Cyp21a1 Cyp21a1 Gm12248 Gm12248 Cyp2f2 Cyp2f2 LOC101842021 LOC101842021 LOC101823194 LOC101823194 Cyp2j6 Cyp2j6 LOC101841752 LOC101841752 Cyp26c1 Cyp26c1 ENSMAUP00000024979 ENSMAUP00000024979 LOC101831527 LOC101831527 Cyp2g1 Cyp2g1 Cyp4f39 Cyp4f39 LOC101830438 LOC101830438 LOC101830378 LOC101830378 Fmo5 Fmo5 LOC101823450 LOC101823450 LOC101826941 LOC101826941 Cyp7b1 Cyp7b1 LOC101842245 LOC101842245 Cyp2t4 Cyp2t4 Cyp2r1 Cyp2r1 Fmo1 Fmo1 LOC101842758 LOC101842758 Fmo6 Fmo6 LOC106021304 LOC106021304 Th Th Pah Pah Moxd1 Moxd1 LOC101843311 LOC101843311 Akr1c14 Akr1c14 Cyp2s1 Cyp2s1 ENSMAUP00000019005 ENSMAUP00000019005 Foxred2 Foxred2 LOC101841267 LOC101841267 Cyp26a1 Cyp26a1 Tph1 Tph1 Cyp4f40 Cyp4f40 LOC101839651 LOC101839651 LOC101843716 LOC101843716
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Cyp26b1Cytochrome P450 26B1; Belongs to the cytochrome P450 family. (512 aa)
Ch25hCholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (284 aa)
LOC101844487Cytochrome P450, family 2 subfamily B polypeptide 29; Belongs to the cytochrome P450 family. (491 aa)
LOC101831088Cytochrome P450 2C26; Catalyzes the hydroxylation of tolbutamide and the N- demethylation of aminopyrine and benzphetamine. (490 aa)
LOC101825889Cytochrome P450 2A8; Highly active in 7-ethoxycoumarin O-deethylation, and benzphetamine N-demethylation; moderately active in testosterone 7- alpha-hydroxylation, ethylmorphine N-demethylation, p-nitroanisole O- demethylation; and only slightly active in benzopyrene 3-hydroxylation, 7-ethoxyresorufin O-deethylation, testosterone 2-alpha-hydroxylation and testosterone 17-oxidation. Competent in the metabolic activation of aflatoxin B1; Belongs to the cytochrome P450 family. (494 aa)
TyrTyrosinase. (530 aa)
Ccdc160Coiled-coil domain-containing protein 160 isoform X2. (323 aa)
Hmox1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (290 aa)
MicalclMICAL C-terminal-like protein. (690 aa)
KmoKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (479 aa)
LOC101833813Cytochrome P450 2B1-like. (456 aa)
Coq75-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (216 aa)
AgmoAlkylglycerol monooxygenase; Belongs to the sterol desaturase family. (449 aa)
ENSMAUP00000018841annotation not available (120 aa)
Nos3Nitric oxide synthase; Produces nitric oxide (NO). (1202 aa)
Nos1Nitric oxide synthase; Produces nitric oxide (NO). (80 aa)
CmahCytidine monophosphate-N-acetylneuraminic acid hydroxylase. (577 aa)
Akr1c18Aldo-keto reductase family 1 member C18 isoform X1. (323 aa)
Tti2TELO2-interacting protein 2. (516 aa)
Nos2Nitric oxide synthase; Produces nitric oxide (NO). (1156 aa)
PtgisProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (493 aa)
LOC101844221Cytochrome P450 2B1-like; Belongs to the cytochrome P450 family. (491 aa)
LOC101844759Cytochrome P450 2B1-like; Belongs to the cytochrome P450 family. (491 aa)
Akr1c19Aldo-keto reductase family 1 member C13-like. (251 aa)
Cyp17a1Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] (431 aa)
LOC101826326Cytochrome P450 2A9; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (493 aa)
Cyp2u1Cytochrome P450 2U1; Belongs to the cytochrome P450 family. (532 aa)
Cyp39a124-hydroxycholesterol 7-alpha-hydroxylase; Belongs to the cytochrome P450 family. (377 aa)
Cyp19a1Aromatase; Belongs to the cytochrome P450 family. (503 aa)
LOC101826047Lanosterol 14-alpha demethylase; Belongs to the cytochrome P450 family. (200 aa)
Cyp2ab1Cytochrome P450 2J2-like; Belongs to the cytochrome P450 family. (280 aa)
MioxInositol oxygenase. (282 aa)
Cyp46a1Cholesterol 24-hydroxylase; Belongs to the cytochrome P450 family. (500 aa)
PamPeptidyl-glycine alpha-amidating monooxygenase isoform X1. (980 aa)
LOC101836914Cytochrome P450 3A31; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (473 aa)
Cyp24a11,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (514 aa)
Gm4847Dimethylaniline monooxygenase [N-oxide-forming]. (538 aa)
DbhDopamine beta-hydroxylase. (620 aa)
Cyp1b1Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (541 aa)
Cyp1a1Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] (507 aa)
LOC101823339Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] (319 aa)
LOC101827747Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa)
LOC101838830LOW QUALITY PROTEIN: cytochrome P450 2D20-like; Belongs to the cytochrome P450 family. (476 aa)
Cyp27a1Sterol 26-hydroxylase, mitochondrial isoform X1; Belongs to the cytochrome P450 family. (534 aa)
Msmo1Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. (293 aa)
Tph2Tryptophan 5-hydroxylase 2. (490 aa)
Cyp4x1Cytochrome P450 4X1; Belongs to the cytochrome P450 family. (505 aa)
Cyp4b1Cytochrome P450 4B1; Belongs to the cytochrome P450 family. (509 aa)
Cyp7a1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
LOC101831958Lithocholate 6-beta-hydroxylase; Catalyzes the 6 beta-hydroxylation of lithocholic acid and steroid hormones; Belongs to the cytochrome P450 family. (503 aa)
Akr1d13-oxo-5-beta-steroid 4-dehydrogenase. (325 aa)
Coq6Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (471 aa)
Mical3Microtubule associated monooxygenase, calponin and LIM domain containing 3. (56 aa)
Cyp4a30bCytochrome P450 4A14-like; Belongs to the cytochrome P450 family. (477 aa)
Fmo9Flavin-containing monooxygenase. (539 aa)
Hmox2Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (316 aa)
Cyp3a13Cytochrome P450 3A9. (503 aa)
Fmo4Dimethylaniline monooxygenase [N-oxide-forming]. (557 aa)
Pcbd1Pterin-4-alpha-carbinolamine dehydratase. (104 aa)
LOC101830103Cytochrome P450 4F5 isoform X1; Belongs to the cytochrome P450 family. (524 aa)
Cyp4f13Cytochrome P450 4F6 isoform X1; Belongs to the cytochrome P450 family. (524 aa)
Tbxas1thromboxane-A synthase. (428 aa)
Cyp1a2Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] (513 aa)
ENSMAUP00000007047annotation not available (75 aa)
Cyp4f14leukotriene-B4 omega-hydroxylase 3 isoform X2; Belongs to the cytochrome P450 family. (524 aa)
LOC101841191Cytochrome P450 2J3-like. (443 aa)
Mical2Microtubule associated monooxygenase, calponin and LIM domain containing 2. (851 aa)
Ccndbp1cyclin-D1-binding protein 1. (305 aa)
DohhDeoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor; Belongs to the deoxyhypusine hydroxylase family. (302 aa)
Cyp27b125-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (508 aa)
Bco1Beta,beta-carotene 15,15'-dioxygenase. (555 aa)
Fmo2Dimethylaniline monooxygenase [N-oxide-forming]. (535 aa)
Mical1F-actin-methionine sulfoxide oxidase MICAL1 isoform X2. (1049 aa)
LOC101844281Cytochrome P450 20A1. (216 aa)
LOC101832144Cytochrome P450 2C28; Catalyzes the N-demethylation of aminopyrine and benzphetamine, but does not catalyze the hydroxylation of tolbutamide, testosterone, and progesterone; Belongs to the cytochrome P450 family. (490 aa)
Cyp2c70Cytochrome P450 2C70-like; Belongs to the cytochrome P450 family. (489 aa)
Cyp8b17-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; Belongs to the cytochrome P450 family. (501 aa)
SqleSqualene monooxygenase. (573 aa)
LOC101843587Aldo-keto reductase family 1 member C21-like isoform X1. (319 aa)
Fmo3Dimethylaniline monooxygenase [N-oxide-forming]. (533 aa)
LOC101830700Cytochrome P450 2J3 isoform X1; Belongs to the cytochrome P450 family. (502 aa)
Saal1Protein SAAL1. (474 aa)
Cyp2w1Cytochrome P450 2W1; Belongs to the cytochrome P450 family. (493 aa)
LOC101829291Cytochrome P450 4F5-like; Belongs to the cytochrome P450 family. (524 aa)
ENSMAUP00000024468annotation not available (458 aa)
Cyp21a1Steroid 21-hydroxylase isoform X2; Belongs to the cytochrome P450 family. (496 aa)
Gm12248Fatty acid hydroxylase domain-containing protein 2; Belongs to the sterol desaturase family. (343 aa)
Cyp2f2Cytochrome P450 2F2; Belongs to the cytochrome P450 family. (491 aa)
LOC101842021Cytochrome P450 2C26-like; Belongs to the cytochrome P450 family. (217 aa)
LOC101823194Cytochrome P450 4A12; Belongs to the cytochrome P450 family. (508 aa)
Cyp2j6Cytochrome P450 2J6-like; Belongs to the cytochrome P450 family. (421 aa)
LOC101841752Cytochrome P450 2C27-like. (401 aa)
Cyp26c1Cytochrome P450 26C1; Belongs to the cytochrome P450 family. (516 aa)
ENSMAUP00000024979annotation not available (426 aa)
LOC101831527Cytochrome P450 2C19-like; Belongs to the cytochrome P450 family. (490 aa)
Cyp2g1Cytochrome P450 2G1 isoform X1; Belongs to the cytochrome P450 family. (494 aa)
Cyp4f39Cytochrome P450 4F22; Belongs to the cytochrome P450 family. (532 aa)
LOC101830438Cytochrome P450 2J3-like isoform X1; Belongs to the cytochrome P450 family. (502 aa)
LOC101830378Cytochrome P450 2C26-like isoform X2; Belongs to the cytochrome P450 family. (490 aa)
Fmo5Flavin containing dimethylaniline monoxygenase 5. (368 aa)
LOC101823450Cytochrome P450 2C25-like. (383 aa)
LOC101826941Cytochrome P450 2A3-like; Belongs to the cytochrome P450 family. (494 aa)
Cyp7b125-hydroxycholesterol 7-alpha-hydroxylase; Belongs to the cytochrome P450 family. (509 aa)
LOC101842245Aldo-keto reductase family 1 member C13-like isoform X1. (311 aa)
Cyp2t4LOW QUALITY PROTEIN: cytochrome P450 2F3-like. (478 aa)
Cyp2r1Vitamin D 25-hydroxylase; Belongs to the cytochrome P450 family. (501 aa)
Fmo1Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
LOC101842758Cytochrome P450 4V2; Belongs to the cytochrome P450 family. (522 aa)
Fmo6Dimethylaniline monooxygenase [N-oxide-forming]. (533 aa)
LOC106021304Cytochrome P450 4A10-like. (368 aa)
ThTyrosine 3-monooxygenase. (498 aa)
PahPhenylalanine-4-hydroxylase. (453 aa)
Moxd1DBH-like monooxygenase protein 1. (613 aa)
LOC1018433113-hydroxyhexobarbital dehydrogenase 1/3-alpha, 17-beta-hydroxysteroid dehydrogenase. (323 aa)
Akr1c143-alpha-hydroxysteroid dehydrogenase-like isoform X1. (323 aa)
Cyp2s1Cytochrome P450 2S1 isoform X1; Belongs to the cytochrome P450 family. (500 aa)
ENSMAUP00000019005annotation not available (354 aa)
Foxred2FAD-dependent oxidoreductase domain-containing protein 2. (666 aa)
LOC101841267prostaglandin-E(2) 9-reductase-like isoform X2. (311 aa)
Cyp26a1Cytochrome P450 26A1; Belongs to the cytochrome P450 family. (497 aa)
Tph1Tryptophan 5-hydroxylase 1. (443 aa)
Cyp4f40Cytochrome P450 4F4-like; Belongs to the cytochrome P450 family. (532 aa)
LOC101839651Aldo-keto reductase family 1 member C21-like. (310 aa)
LOC101843716Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. (493 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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