Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ch25h | Cyp17a1 | ENSMAUP00000002020 | ENSMAUP00000015990 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.410 |
| Ch25h | Cyp1b1 | ENSMAUP00000002020 | ENSMAUP00000012410 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Cytochrome P450 1B1; Belongs to the cytochrome P450 family. | 0.407 |
| Ch25h | Cyp21a1 | ENSMAUP00000002020 | ENSMAUP00000025484 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Steroid 21-hydroxylase isoform X2; Belongs to the cytochrome P450 family. | 0.404 |
| Ch25h | Cyp27a1 | ENSMAUP00000002020 | ENSMAUP00000011597 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Sterol 26-hydroxylase, mitochondrial isoform X1; Belongs to the cytochrome P450 family. | 0.919 |
| Ch25h | Cyp39a1 | ENSMAUP00000002020 | ENSMAUP00000015175 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | 24-hydroxycholesterol 7-alpha-hydroxylase; Belongs to the cytochrome P450 family. | 0.948 |
| Ch25h | Cyp46a1 | ENSMAUP00000002020 | ENSMAUP00000013463 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Cholesterol 24-hydroxylase; Belongs to the cytochrome P450 family. | 0.944 |
| Ch25h | Cyp7a1 | ENSMAUP00000002020 | ENSMAUP00000011088 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 0.979 |
| Ch25h | Cyp7b1 | ENSMAUP00000002020 | ENSMAUP00000022904 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | 25-hydroxycholesterol 7-alpha-hydroxylase; Belongs to the cytochrome P450 family. | 0.979 |
| Ch25h | Cyp8b1 | ENSMAUP00000002020 | ENSMAUP00000003881 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; Belongs to the cytochrome P450 family. | 0.907 |
| Ch25h | LOC101823339 | ENSMAUP00000002020 | ENSMAUP00000012066 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] | 0.604 |
| Ch25h | LOC101827747 | ENSMAUP00000002020 | ENSMAUP00000011954 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] | 0.604 |
| Ch25h | Ptgis | ENSMAUP00000002020 | ENSMAUP00000017258 | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. | 0.933 |
| Cyp17a1 | Ch25h | ENSMAUP00000015990 | ENSMAUP00000002020 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. | 0.410 |
| Cyp17a1 | Cyp1a1 | ENSMAUP00000015990 | ENSMAUP00000012248 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | 0.867 |
| Cyp17a1 | Cyp1a2 | ENSMAUP00000015990 | ENSMAUP00000007198 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] | 0.869 |
| Cyp17a1 | Cyp1b1 | ENSMAUP00000015990 | ENSMAUP00000012410 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Cytochrome P450 1B1; Belongs to the cytochrome P450 family. | 0.713 |
| Cyp17a1 | Cyp21a1 | ENSMAUP00000015990 | ENSMAUP00000025484 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Steroid 21-hydroxylase isoform X2; Belongs to the cytochrome P450 family. | 0.897 |
| Cyp17a1 | Cyp27a1 | ENSMAUP00000015990 | ENSMAUP00000011597 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Sterol 26-hydroxylase, mitochondrial isoform X1; Belongs to the cytochrome P450 family. | 0.490 |
| Cyp17a1 | Cyp2ab1 | ENSMAUP00000015990 | ENSMAUP00000013818 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Cytochrome P450 2J2-like; Belongs to the cytochrome P450 family. | 0.528 |
| Cyp17a1 | Cyp2c70 | ENSMAUP00000015990 | ENSMAUP00000004415 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Cytochrome P450 2C70-like; Belongs to the cytochrome P450 family. | 0.885 |
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