STRINGSTRING
Dnmt1 Dnmt1 Stk4 Stk4 Pou4f2 Pou4f2 Hsf1 Hsf1 Ptk2b Ptk2b Slc25a4 Slc25a4 Agt Agt Rapgef3 Rapgef3 Map3k5 Map3k5 Ccdc142 Ccdc142 Nfe2l2 Nfe2l2 Gria4 Gria4 Atg5 Atg5 Edn1 Edn1 Lifr Lifr Gsk3b Gsk3b LOC101833362 LOC101833362 E2f3 E2f3 Camk2a Camk2a Ilk Ilk Cflar Cflar Myocd Myocd Slc7a5 Slc7a5 Igf1 Igf1 Sod2 Sod2 Erbb4 Erbb4 Alox12 Alox12 Arrb1 Arrb1 Apoh Apoh LOC101839104 LOC101839104 Adcyap1 Adcyap1 Gata4 Gata4 Cftr Cftr Camk2d Camk2d Sfrp2 Sfrp2 Arrb2 Arrb2 Zc3h12a Zc3h12a Igfbp3 Igfbp3 Hand2 Hand2 Nupr1 Nupr1 Pparg Pparg Capn2 Capn2 Atf4 Atf4 Pdcd4 Pdcd4 Tigar Tigar Rbm10 Rbm10 Pcmt1 Pcmt1 Lypd3 Lypd3 Hey2 Hey2 Bcl2 Bcl2 Igf1r Igf1r Sirt4 Sirt4 Bag3 Bag3 Lrp6 Lrp6 Ppp1r10 Ppp1r10 Dicer1 Dicer1 Sirt5 Sirt5 Smad4 Smad4 Capn1 Capn1 Ambra1 Ambra1 Mfn2 Mfn2 Jak2 Jak2 Sirt1 Sirt1 Pik3r1 Pik3r1 Pdpk1 Pdpk1 Eif5al1 Eif5al1 Rgl2-2 Rgl2-2 Fbxo32 Fbxo32 Nkx2-5 Nkx2-5 Dipk2a Dipk2a Mdk Mdk Il12a Il12a Pten Pten Cav1 Cav1 Trip10 Trip10 Pax8 Pax8 Gata6 Gata6 Cdkn2a Cdkn2a Cxcr2 Cxcr2 Fndc1 Fndc1 Kifap3 Kifap3 Ltk Ltk Nol3 Nol3 LOC101840102 LOC101840102 Trem1 Trem1 Hmox1 Hmox1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Dnmt1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1599 aa)
Stk4Serine/threonine-protein kinase 4. (448 aa)
Pou4f2POU domain protein. (408 aa)
Hsf1Heat shock factor protein 1. (423 aa)
Ptk2bProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
Slc25a4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
AgtAngiotensinogen; Belongs to the serpin family. (482 aa)
Rapgef3Rap guanine nucleotide exchange factor 3 isoform X4. (926 aa)
Map3k5Mitogen-activated protein kinase kinase kinase 5 isoform X2. (1381 aa)
Ccdc142Coiled-coil domain-containing protein 142. (734 aa)
Nfe2l2Nuclear factor erythroid 2-related factor 2 isoform X1. (604 aa)
Gria4Glutamate receptor 4 isoform X2. (433 aa)
Atg5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
Edn1Endothelin-1. (202 aa)
LifrLeukemia inhibitory factor receptor. (950 aa)
Gsk3bGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (429 aa)
LOC101833362BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (187 aa)
E2f3Transcription factor E2F3 isoform X1. (460 aa)
Camk2aCalcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (459 aa)
IlkIntegrin-linked protein kinase. (452 aa)
CflarCASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (219 aa)
MyocdMyocardin. (931 aa)
Slc7a5Large neutral amino acids transporter small subunit 1. (506 aa)
Igf1Insulin-like growth factor 1. (153 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
Erbb4Receptor protein-tyrosine kinase. (1308 aa)
Alox12Arachidonate 12-lipoxygenase, 12S-type isoform X2. (663 aa)
Arrb1Beta-arrestin-1 isoform X3. (418 aa)
ApohBeta-2-glycoprotein 1. (297 aa)
LOC101839104Insulin-like growth factor-binding protein 3. (177 aa)
Adcyap1Pituitary adenylate cyclase-activating polypeptide isoform X1. (175 aa)
Gata4Transcription factor GATA-4 isoform X2. (443 aa)
CftrCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1184 aa)
Camk2dCalcium/calmodulin-dependent protein kinase type II subunit delta. (160 aa)
Sfrp2Secreted frizzled-related protein 2 precursor. (295 aa)
Arrb2Beta-arrestin-2. (279 aa)
Zc3h12aEndoribonuclease ZC3H12A. (592 aa)
Igfbp3Insulin-like growth factor-binding protein 3. (292 aa)
Hand2Heart- and neural crest derivatives-expressed protein 2. (217 aa)
Nupr1Nuclear protein 1. (80 aa)
PpargPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (217 aa)
Capn2Calpain-2 catalytic subunit; Belongs to the peptidase C2 family. (725 aa)
Atf4Cyclic AMP-dependent transcription factor ATF-4. (350 aa)
Pdcd4Programmed cell death protein 4. (469 aa)
TigarFructose-2,6-bisphosphatase TIGAR. (266 aa)
Rbm10RNA-binding protein 10 isoform X5. (931 aa)
Pcmt1Protein-L-isoaspartate O-methyltransferase. (227 aa)
Lypd3ly6/PLAUR domain-containing protein 3. (351 aa)
Hey2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
Bcl2Apoptosis regulator Bcl-2. (236 aa)
Igf1rTyrosine-protein kinase receptor. (1154 aa)
Sirt4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (311 aa)
Bag3BAG family molecular chaperone regulator 3. (532 aa)
Lrp6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1601 aa)
Ppp1r10Serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1. (930 aa)
Dicer1Endoribonuclease Dicer isoform X1; Belongs to the helicase family. Dicer subfamily. (1917 aa)
Sirt5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (310 aa)
Smad4Mothers against decapentaplegic homolog. (552 aa)
Capn1Calpain-1 catalytic subunit; Belongs to the peptidase C2 family. (197 aa)
Ambra1Activating molecule in BECN1-regulated autophagy protein 1. (1195 aa)
Mfn2Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
Jak2Tyrosine-protein kinase. (1132 aa)
Sirt1NAD-dependent protein deacetylase sirtuin-1. (691 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
Pdpk13-phosphoinositide-dependent protein kinase 1 isoform X2. (559 aa)
Eif5al1Eukaryotic translation initiation factor 5A. (124 aa)
Rgl2-2Ral guanine nucleotide dissociation stimulator-like 2 isoform X1. (255 aa)
Fbxo32F-box only protein 32. (355 aa)
Nkx2-5Homeobox protein Nkx-2.5. (317 aa)
Dipk2aDeleted in autism protein 1. (430 aa)
MdkMidkine. (143 aa)
Il12aInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (206 aa)
PtenPhosphatase and tensin homolog. (403 aa)
Cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
Trip10Cdc42-interacting protein 4 isoform X2. (548 aa)
Pax8Paired box protein Pax-8 isoform X2. (457 aa)
Gata6Transcription factor GATA-6. (442 aa)
Cdkn2aCyclin-dependent kinase inhibitor 2A. (157 aa)
Cxcr2C-X-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (359 aa)
Fndc1Fibronectin type III domain-containing protein 1 isoform X1. (1773 aa)
Kifap3Kinesin-associated protein 3 isoform X1. (793 aa)
LtkTyrosine-protein kinase receptor. (835 aa)
Nol3Nucleolar protein 3 isoform X2. (206 aa)
LOC101840102Eukaryotic translation initiation factor 5A. (86 aa)
Trem1Triggering receptor expressed on myeloid cells 1. (215 aa)
Hmox1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (290 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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