STRINGSTRING
Slc25a4 Slc25a4 Nol3 Nol3 Kifap3 Kifap3 Pax8 Pax8 Trip10 Trip10 Mdk Mdk Nkx2-5 Nkx2-5 Rgl2-2 Rgl2-2 Pdpk1 Pdpk1 Sirt1 Sirt1 Jak2 Jak2 Mfn2 Mfn2 Ambra1 Ambra1 Sirt5 Sirt5 Ppp1r10 Ppp1r10 Sirt4 Sirt4 Bcl2 Bcl2 Hey2 Hey2 Pcmt1 Pcmt1 Nupr1 Nupr1 Hand2 Hand2 Sfrp2 Sfrp2 Gata4 Gata4 Atg5 Atg5 Nfe2l2 Nfe2l2 Rapgef3 Rapgef3 Hsf1 Hsf1 Ilk Ilk Cflar Cflar Myocd Myocd
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Slc25a4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
Nol3Nucleolar protein 3 isoform X2. (206 aa)
Kifap3Kinesin-associated protein 3 isoform X1. (793 aa)
Pax8Paired box protein Pax-8 isoform X2. (457 aa)
Trip10Cdc42-interacting protein 4 isoform X2. (548 aa)
MdkMidkine. (143 aa)
Nkx2-5Homeobox protein Nkx-2.5. (317 aa)
Rgl2-2Ral guanine nucleotide dissociation stimulator-like 2 isoform X1. (255 aa)
Pdpk13-phosphoinositide-dependent protein kinase 1 isoform X2. (559 aa)
Sirt1NAD-dependent protein deacetylase sirtuin-1. (691 aa)
Jak2Tyrosine-protein kinase. (1132 aa)
Mfn2Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
Ambra1Activating molecule in BECN1-regulated autophagy protein 1. (1195 aa)
Sirt5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (310 aa)
Ppp1r10Serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1. (930 aa)
Sirt4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (311 aa)
Bcl2Apoptosis regulator Bcl-2. (236 aa)
Hey2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
Pcmt1Protein-L-isoaspartate O-methyltransferase. (227 aa)
Nupr1Nuclear protein 1. (80 aa)
Hand2Heart- and neural crest derivatives-expressed protein 2. (217 aa)
Sfrp2Secreted frizzled-related protein 2 precursor. (295 aa)
Gata4Transcription factor GATA-4 isoform X2. (443 aa)
Atg5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
Nfe2l2Nuclear factor erythroid 2-related factor 2 isoform X1. (604 aa)
Rapgef3Rap guanine nucleotide exchange factor 3 isoform X4. (926 aa)
Hsf1Heat shock factor protein 1. (423 aa)
IlkIntegrin-linked protein kinase. (452 aa)
CflarCASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (219 aa)
MyocdMyocardin. (931 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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