STRINGSTRING
Masp2 Masp2 Stat6 Stat6 H2-DMa H2-DMa C1r C1r C8b C8b Rnf8 Rnf8 ENSMAUP00000004122 ENSMAUP00000004122 Xrcc4 Xrcc4 Batf Batf Tnfsf13 Tnfsf13 Kiaa1841 Kiaa1841 Mbl2 Mbl2 LOC106021697 LOC106021697 C6 C6 Igll5 Igll5 C1rl C1rl Inpp5d Inpp5d Exosc6 Exosc6 Exosc3 Exosc3 ENSMAUP00000007509 ENSMAUP00000007509 Il4 Il4 Cr2 Cr2 Myd88 Myd88 Exo1 Exo1 C1s C1s LOC106021236 LOC106021236 Hspd1 Hspd1 C7 C7 Cr1l Cr1l Cd81 Cd81 C9 C9 Lig4 Lig4 Bcl3 Bcl3 Traf3ip2-2 Traf3ip2-2 Msh2 Msh2 Atad5 Atad5 Irf7 Irf7 Cd40lg Cd40lg H2-Ab1 H2-Ab1 Card9 Card9 Zp3 Zp3 Cfi Cfi C1qbp C1qbp ENSMAUP00000024144 ENSMAUP00000024144 Prkcd Prkcd Nbn Nbn C1qc C1qc Ccr6 Ccr6 Bcl10 Bcl10 C8a C8a Ung Ung Il4r Il4r Aicda Aicda Def6 Def6 C1qa C1qa Traf3ip2 Traf3ip2 Swap70 Swap70 Serping1 Serping1 C3 C3 Rnf168 Rnf168 Il21r Il21r Cd55 Cd55 Trex1 Trex1 ENSMAUP00000014320 ENSMAUP00000014320 Il9r Il9r Tcirg1 Tcirg1 Mbl1 Mbl1 Ercc1 Ercc1 Morn5 Morn5 Il13ra2 Il13ra2 Bcl6 Bcl6 Fcer1g Fcer1g C4b C4b Fcgr2b Fcgr2b Btk Btk Il9 Il9 Mlh1 Mlh1 LOC101830849 LOC101830849 Cd74 Cd74 Foxp3 Foxp3 ENSMAUP00000017484 ENSMAUP00000017484 C1qb C1qb C4bp C4bp ENSMAUP00000018538 ENSMAUP00000018538
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Masp2Mannan-binding lectin serine protease 2 isoform X1; Belongs to the peptidase S1 family. (685 aa)
Stat6Signal transducer and activator of transcription. (746 aa)
H2-DMaClass II histocompatibility antigen, M alpha chain; Belongs to the MHC class II family. (261 aa)
C1rComplement C1r subcomponent; Belongs to the peptidase S1 family. (705 aa)
C8bComplement component C8 beta chain isoform X1. (588 aa)
Rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (488 aa)
ENSMAUP00000004122annotation not available (116 aa)
Xrcc4DNA repair protein XRCC4 isoform X2. (327 aa)
BatfBasic leucine zipper transcriptional factor ATF-like. (125 aa)
Tnfsf13Tumor necrosis factor ligand superfamily member 13 isoform X2; Belongs to the tumor necrosis factor family. (241 aa)
Kiaa1841Uncharacterized protein KIAA1841 homolog isoform X4. (189 aa)
Mbl2Mannose-binding protein C isoform X2. (244 aa)
LOC106021697DNA mismatch repair protein Msh6. (191 aa)
C6Complement component C6. (732 aa)
Igll5Immunoglobulin lambda-like polypeptide 5. (209 aa)
C1rlLOW QUALITY PROTEIN: complement C1r subcomponent-like protein; Belongs to the peptidase S1 family. (485 aa)
Inpp5dPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1153 aa)
Exosc6Exosome complex component MTR3. (272 aa)
Exosc3Exosome complex component RRP40. (274 aa)
ENSMAUP00000007509annotation not available (458 aa)
Il4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (147 aa)
Cr2Complement receptor type 2 isoform X1. (1410 aa)
Myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
Exo1Exonuclease 1 isoform X1. (191 aa)
C1sCalcium-dependent serine proteinase heavy chain; Capable of degrading extracellular matrix proteins. CASP degrades type I and IV collagen and fibronectin in the presence of calcium; Belongs to the peptidase S1 family. (695 aa)
LOC106021236LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial-like; Belongs to the chaperonin (HSP60) family. (569 aa)
Hspd160 kDa heat shock protein, mitochondrial. (387 aa)
C7Complement component C7. (827 aa)
Cr1lComplement component receptor 1-like protein. (401 aa)
Cd81Tetraspanin. (236 aa)
C9Complement component C9. (570 aa)
Lig4DNA ligase. (848 aa)
Bcl3B-cell lymphoma 3 protein. (292 aa)
Traf3ip2-2Adapter protein CIKS isoform X2. (264 aa)
Msh2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
Atad5ATPase family AAA domain-containing protein 5. (1819 aa)
Irf7Interferon regulatory factor 7 isoform X1. (394 aa)
Cd40lgCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
H2-Ab1Rano class II histocompatibility antigen, A beta chain-like. (263 aa)
Card9Caspase recruitment domain-containing protein 9 isoform X2. (537 aa)
Zp3Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation; Belongs to the ZP domain family. ZPC subfamily. (422 aa)
CfiComplement factor I; Belongs to the peptidase S1 family. (599 aa)
C1qbpComplement component 1 Q subcomponent-binding protein, mitochondrial. (281 aa)
ENSMAUP00000024144annotation not available (159 aa)
PrkcdProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
NbnNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (556 aa)
C1qcComplement C1q subcomponent subunit C. (245 aa)
Ccr6C-C chemokine receptor type 6 isoform X1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
Bcl10B-cell lymphoma/leukemia 10. (232 aa)
C8aComplement component C8 alpha chain. (582 aa)
UngUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (199 aa)
Il4rInterleukin-4 receptor subunit alpha. (42 aa)
AicdaSingle-stranded DNA cytosine deaminase. (198 aa)
Def6Differentially expressed in FDCP 6 homolog. (630 aa)
C1qaComplement C1q subcomponent subunit A. (245 aa)
Traf3ip2Adapter protein CIKS isoform X4. (109 aa)
Swap70Switch-associated protein 70. (585 aa)
Serping1Plasma protease C1 inhibitor; Belongs to the serpin family. (547 aa)
C3Complement C3. (1483 aa)
Rnf168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (537 aa)
Il21rInterleukin-21 receptor. (537 aa)
Cd55Complement decay-accelerating factor isoform X2. (208 aa)
Trex1Three-prime repair exonuclease 1. (313 aa)
ENSMAUP00000014320annotation not available (157 aa)
Il9rInterleukin-9 receptor isoform X1. (477 aa)
Tcirg1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (832 aa)
Mbl1Mannose-binding protein A-like. (235 aa)
Ercc1DNA excision repair protein ERCC-1. (297 aa)
Morn5MORN repeat-containing protein 5. (171 aa)
Il13ra2Interleukin-13 receptor subunit alpha-2. (417 aa)
Bcl6B-cell lymphoma 6 protein. (707 aa)
Fcer1gHigh affinity immunoglobulin epsilon receptor subunit gamma. (86 aa)
C4bComplement C4 isoform X2. (1738 aa)
Fcgr2bLow affinity immunoglobulin gamma Fc region receptor II-b isoform X2. (340 aa)
BtkTyrosine-protein kinase. (659 aa)
Il9Interleukin-9. (147 aa)
Mlh1DNA mismatch repair protein Mlh1. (720 aa)
LOC101830849B-cell lymphoma 3 protein homolog. (114 aa)
Cd74HLA class II histocompatibility antigen gamma chain isoform X1. (289 aa)
Foxp3Forkhead box protein P3 isoform X3. (427 aa)
ENSMAUP00000017484annotation not available (397 aa)
C1qbComplement C1q subcomponent subunit B isoform X2. (254 aa)
C4bpC4b-binding protein alpha chain. (449 aa)
ENSMAUP00000018538annotation not available (171 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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