STRINGSTRING
Pcsk1 Pcsk1 Six3 Six3 Fgf10 Fgf10 Wnt1 Wnt1 Olig2 Olig2 Pou4f1 Pou4f1 Hes1 Hes1 Ptchd4 Ptchd4 Prop1 Prop1 Gsx1 Gsx1 Tcf7l2 Tcf7l2 Wnt5a Wnt5a Fgf2 Fgf2 Duox2 Duox2 Bmp2 Bmp2 Cdh1 Cdh1 Hesx1 Hesx1 Hap1 Hap1 Bax Bax Zeb2 Zeb2 LOC101832402 LOC101832402 Aldh1a2 Aldh1a2 Bmpr1a Bmpr1a Fgf8 Fgf8 Lhx3 Lhx3 Gli2 Gli2 Nog Nog Tal2 Tal2 Pou1f1 Pou1f1 Myc Myc Otp Otp Gata2 Gata2 Nr4a2 Nr4a2 Pax6 Pax6 Isl1 Isl1 Ndnf Ndnf Smo Smo Shh Shh Crh Crh Crhr1 Crhr1 Rax Rax Srd5a2 Srd5a2 Hmga2 Hmga2 Nhlh2 Nhlh2 Sox2 Sox2 Otx2 Otx2 Creb1 Creb1 Tbx19 Tbx19 Kdm1a Kdm1a Inhbb Inhbb Sall1 Sall1 Otx1 Otx1 Plxna3 Plxna3 Ncor1 Ncor1 Nkx2-1 Nkx2-1 Foxb1 Foxb1 Rbpj Rbpj Kcnc1 Kcnc1 Nrp2 Nrp2 Srd5a1 Srd5a1 Gbx2 Gbx2 Ncam1 Ncam1 Uqcrq Uqcrq Chrnb2 Chrnb2 Adcyap1 Adcyap1 Pitx1 Pitx1 Nrp1 Nrp1 Rab3gap1 Rab3gap1 Nkx2-6 Nkx2-6 Ptchd1 Ptchd1 Arx Arx Bmp4 Bmp4 Ctnnb1 Ctnnb1 Sema3a Sema3a Pitx2 Pitx2 Pou3f2 Pou3f2 Lrp6 Lrp6 Kcnc2 Kcnc2 Gli1 Gli1 Drd2 Drd2 Wnt4 Wnt4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Pcsk1Proprotein convertase subtilisin/kexin type 1. (607 aa)
Six3Homeobox protein SIX3. (279 aa)
Fgf10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
Wnt1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
Olig2Oligodendrocyte transcription factor 2. (322 aa)
Pou4f1POU domain protein. (292 aa)
Hes1Transcription factor HES-1. (281 aa)
Ptchd4Patched domain-containing protein 4 isoform X2. (901 aa)
Prop1Homeobox protein prophet of Pit-1. (223 aa)
Gsx1GS homeobox 1. (265 aa)
Tcf7l2Transcription factor 7-like 2 isoform X17. (598 aa)
Wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
Duox2Dual oxidase 2. (1306 aa)
Bmp2Bone morphogenetic protein 2 isoform X1. (394 aa)
Cdh1Cadherin-1 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (886 aa)
Hesx1Homeobox expressed in ES cells 1. (185 aa)
Hap1Huntingtin-associated protein 1 isoform X2. (648 aa)
BaxApoptosis regulator BAX isoform X1. (192 aa)
Zeb2Zinc finger E-box-binding homeobox 2 isoform X1. (1214 aa)
LOC101832402Uncharacterized protein LOC101832402. (131 aa)
Aldh1a2Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. (518 aa)
Bmpr1aReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
Fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
Lhx3LIM/homeobox protein Lhx3 isoform X1. (403 aa)
Gli2Zinc finger protein GLI2. (1544 aa)
NogNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
Tal2T-cell acute lymphocytic leukemia protein 2. (108 aa)
Pou1f1Pituitary-specific positive transcription factor 1. (227 aa)
MycMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
OtpHomeobox protein orthopedia. (325 aa)
Gata2Endothelial transcription factor GATA-2. (480 aa)
Nr4a2Nuclear receptor subfamily 4 group A member 2 isoform X1. (598 aa)
Pax6Paired box protein Pax-6 isoform X1. (436 aa)
Isl1Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for [...] (349 aa)
NdnfProtein NDNF. (568 aa)
SmoSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (757 aa)
ShhHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (439 aa)
CrhCorticoliberin. (187 aa)
Crhr1Type-1 corticotropin-releasing hormone receptor alpha isoform; Belongs to the G-protein coupled receptor 2 family. (415 aa)
RaxRetinal homeobox protein Rx. (341 aa)
Srd5a23-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (253 aa)
Hmga2High mobility group protein HMGI-C isoform X1. (108 aa)
Nhlh2Helix-loop-helix protein 2. (135 aa)
Sox2Transcription factor SOX-2. (319 aa)
Otx2Homeobox protein OTX2. (289 aa)
Creb1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
Tbx19T-box transcription factor TBX19. (447 aa)
Kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (870 aa)
InhbbInhibin beta B chain. (411 aa)
Sall1Sal-like protein 1. (1318 aa)
Otx1Homeobox protein OTX1. (355 aa)
Plxna3plexin-A3 isoform X1. (1872 aa)
Ncor1Nuclear receptor corepressor 1. (2242 aa)
Nkx2-1Homeobox protein Nkx-2.1 isoform X2. (372 aa)
Foxb1Forkhead box protein B1. (325 aa)
RbpjRecombining binding protein suppressor of hairless isoform X1. (526 aa)
Kcnc1Potassium voltage-gated channel subfamily C member 1 isoform X2; Belongs to the potassium channel family. (585 aa)
Nrp2Neuropilin; Belongs to the neuropilin family. (931 aa)
Srd5a13-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (255 aa)
Gbx2Homeobox protein GBX-2. (348 aa)
Ncam1Neural cell adhesion molecule 1 isoform X5. (851 aa)
UqcrqCytochrome b-c1 complex subunit 8. (82 aa)
Chrnb2Neuronal acetylcholine receptor subunit beta-2. (502 aa)
Adcyap1Pituitary adenylate cyclase-activating polypeptide isoform X1. (175 aa)
Pitx1Homeobox protein. (314 aa)
Nrp1Neuropilin; Belongs to the neuropilin family. (910 aa)
Rab3gap1Rab3 GTPase-activating protein catalytic subunit. (939 aa)
Nkx2-6Homeobox protein Nkx-2.6. (277 aa)
Ptchd1Patched domain-containing protein 1. (888 aa)
ArxHomeobox protein ARX. (557 aa)
Bmp4Bone morphogenetic protein 4. (409 aa)
Ctnnb1Catenin beta-1. (781 aa)
Sema3asemaphorin-3A; Belongs to the semaphorin family. (772 aa)
Pitx2Homeobox protein. (324 aa)
Pou3f2POU domain protein. (445 aa)
Lrp6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1601 aa)
Kcnc2Potassium voltage-gated channel subfamily C member 2. (405 aa)
Gli1Zinc finger protein GLI1. (981 aa)
Drd2D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (444 aa)
Wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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