(87 nodes) Actin filament-based movement network (Mesocricetus auratus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	Cacna1g	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (385 aa)
	Abcc9	ATP-binding cassette sub-family C member 9 isoform X2. (1550 aa)
	Ryr2	LOW QUALITY PROTEIN: ryanodine receptor 2. (4881 aa)
	Kcnj8	ATP-sensitive inward rectifier potassium channel 8. (424 aa)
	Actc1	Actin, alpha cardiac muscle 1. (377 aa)
	Kcne4	Potassium voltage-gated channel subfamily E member 4. (50 aa)
	Gpd1l	Glycerol-3-phosphate dehydrogenase [NAD(+)]. (351 aa)
	Kcnq1	Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (669 aa)
	Kcnj2	Inward rectifier potassium channel 2. (427 aa)
	Myo5c	Unconventional myosin-Vc; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1733 aa)
	Myl6b	Myosin light chain 6B. (221 aa)
	Pik3ca	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	Wipf1	WAS/WASL-interacting protein family member 1. (497 aa)
	Wasl	Neural Wiskott-Aldrich syndrome protein. (501 aa)
	Kcnd3	Potassium voltage-gated channel subfamily D member 3 isoform X1; Belongs to the potassium channel family. (655 aa)
	Myl6	Myosin light polypeptide 6 isoform X2. (151 aa)
	Cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	Myo1a	Unconventional myosin-Ia; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1043 aa)
	Wipf3	WAS/WASL-interacting protein family member 3. (502 aa)
	Cacna1c	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2194 aa)
	Myo15b	Myosin XVB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (512 aa)
	Gsn	Gelsolin isoform X1. (778 aa)
	Syne2	Nesprin-2. (804 aa)
	Myo15	Unconventional myosin-XV; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (3481 aa)
	Myh9	Myosin-9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)
	Gja5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
	Epb41l5	Band 4.1-like protein 5 isoform X1. (114 aa)
	Frmd6	FERM domain-containing protein 6 isoform X1. (619 aa)
	Tpm1	Tropomyosin alpha-1 chain isoform X7; Belongs to the tropomyosin family. (326 aa)
	Ccdc88c	Protein Daple. (2003 aa)
	Scn5a	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2021 aa)
	ENSMAUP00000015453	annotation not available (164 aa)
	Myo1h	Unconventional myosin-Ih; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1038 aa)
	Myh10	Myosin-10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1976 aa)
	Snta1	Alpha-1-syntrophin. (491 aa)
	Kcnn2	Small conductance calcium-activated potassium channel protein 2 isoform X1. (839 aa)
	Camk2d	Calcium/calmodulin-dependent protein kinase type II subunit delta. (160 aa)
	Scn3b	Sodium channel subunit beta-3. (215 aa)
	ENSMAUP00000013256	annotation not available (90 aa)
	Myo1b	Unconventional myosin-Ib isoform X3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (862 aa)
	Pdpn	Podoplanin. (162 aa)
	Myo1d	Unconventional myosin-Id isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1006 aa)
	Myh14	LOW QUALITY PROTEIN: myosin-14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1979 aa)
	ENSMAUP00000012145	annotation not available (374 aa)
	Myo7b	Unconventional myosin-VIIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2071 aa)
	Wasf2	wiskott-Aldrich syndrome protein family member 2-like. (385 aa)
	Emp2	Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (172 aa)
	Kcnh2	Potassium voltage-gated channel subfamily H member 2 isoform X1. (1163 aa)
	Rock1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
	Kcnj5	G protein-activated inward rectifier potassium channel 4. (343 aa)
	Pard3	Partitioning defective 3 homolog isoform X3. (1334 aa)
	ENSMAUP00000010641	annotation not available (100 aa)
	Kcne3	Potassium voltage-gated channel subfamily E member 3. (103 aa)
	LOC106022467	Myosin-7. (1037 aa)
	Myh6	Myosin-6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1382 aa)
	Kcna5	Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (539 aa)
	Pkp2	Plakophilin-2 isoform X1. (794 aa)
	Tnnt2	Troponin T, cardiac muscle. (216 aa)
	Myo1c	Unconventional myosin-Ic; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (856 aa)
	Parva	Alpha-parvin. (342 aa)
	ENSMAUP00000007234	annotation not available (110 aa)
	Myo19	Unconventional myosin-XIX; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (930 aa)
	ENSMAUP00000006623	annotation not available (500 aa)
	Myo1e	Unconventional myosin-Ie; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (924 aa)
	Kcne1	Potassium voltage-gated channel subfamily E member 1 isoform X1. (129 aa)
	Myo6	Unconventional myosin-VI isoform X2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1272 aa)
	Scn2b	Sodium channel subunit beta-2. (215 aa)
	Epdr1	Mammalian ependymin-related protein 1. (229 aa)
	Cacna2d1	Voltage-dependent calcium channel subunit alpha-2/delta-1. (1017 aa)
	Cacnb2	Voltage-dependent L-type calcium channel subunit beta-2 isoform X1. (655 aa)
	ENSMAUP00000003329	annotation not available (502 aa)
	Nup155	Nucleoporin 155. (912 aa)
	Myo7a	Unconventional myosin-VIIa isoform X2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2177 aa)
	Wipf2	WAS/WASL-interacting protein family member 2. (440 aa)
	Kcne5	Potassium voltage-gated channel subfamily E regulatory beta subunit 5. (143 aa)
	Myo1f	Unconventional myosin-If; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1098 aa)
	Myo5a	Unconventional myosin-Va; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1810 aa)
	ENSMAUP00000001689	annotation not available (1186 aa)
	Actn4	Actinin alpha 4. (523 aa)
	Vil1	Villin-1. (859 aa)
	Scn4b	Sodium channel subunit beta-4. (228 aa)
	Slc9a1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (412 aa)
	Myo5b	Unconventional myosin-Vb isoform X2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1843 aa)
	Kcne2	Potassium voltage-gated channel subfamily E member 2. (123 aa)
	Scn1b	Sodium channel subunit beta-1. (218 aa)
	Was	wiskott-Aldrich syndrome protein. (515 aa)
	Fnbp1l	Formin-binding protein 1-like. (587 aa)

Your Current Organism:

Mesocricetus auratus

NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Abcc9	Kcne3	ENSMAUP00000025783	ENSMAUP00000010617	ATP-binding cassette sub-family C member 9 isoform X2.	Potassium voltage-gated channel subfamily E member 3.	0.506
Abcc9	Kcnj2	ENSMAUP00000025783	ENSMAUP00000022899	ATP-binding cassette sub-family C member 9 isoform X2.	Inward rectifier potassium channel 2.	0.704
Abcc9	Kcnj5	ENSMAUP00000025783	ENSMAUP00000010775	ATP-binding cassette sub-family C member 9 isoform X2.	G protein-activated inward rectifier potassium channel 4.	0.714
Abcc9	Kcnj8	ENSMAUP00000025783	ENSMAUP00000024985	ATP-binding cassette sub-family C member 9 isoform X2.	ATP-sensitive inward rectifier potassium channel 8.	0.996
Abcc9	Pard3	ENSMAUP00000025783	ENSMAUP00000010705	ATP-binding cassette sub-family C member 9 isoform X2.	Partitioning defective 3 homolog isoform X3.	0.404
Actc1	Actn4	ENSMAUP00000024705	ENSMAUP00000001548	Actin, alpha cardiac muscle 1.	Actinin alpha 4.	0.665
Actc1	Cav3	ENSMAUP00000024705	ENSMAUP00000021421	Actin, alpha cardiac muscle 1.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.638
Actc1	ENSMAUP00000013256	ENSMAUP00000024705	ENSMAUP00000013256	Actin, alpha cardiac muscle 1.	annotation not available	0.744
Actc1	ENSMAUP00000015453	ENSMAUP00000024705	ENSMAUP00000015453	Actin, alpha cardiac muscle 1.	annotation not available	0.505
Actc1	Fnbp1l	ENSMAUP00000024705	ENSMAUP00000000278	Actin, alpha cardiac muscle 1.	Formin-binding protein 1-like.	0.421
Actc1	Gsn	ENSMAUP00000024705	ENSMAUP00000018710	Actin, alpha cardiac muscle 1.	Gelsolin isoform X1.	0.626
Actc1	LOC106022467	ENSMAUP00000024705	ENSMAUP00000010516	Actin, alpha cardiac muscle 1.	Myosin-7.	0.901
Actc1	Myh10	ENSMAUP00000024705	ENSMAUP00000014658	Actin, alpha cardiac muscle 1.	Myosin-10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.803
Actc1	Myh14	ENSMAUP00000024705	ENSMAUP00000012537	Actin, alpha cardiac muscle 1.	LOW QUALITY PROTEIN: myosin-14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.780
Actc1	Myh6	ENSMAUP00000024705	ENSMAUP00000010028	Actin, alpha cardiac muscle 1.	Myosin-6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.901
Actc1	Myh9	ENSMAUP00000024705	ENSMAUP00000018272	Actin, alpha cardiac muscle 1.	Myosin-9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.803
Actc1	Myl6	ENSMAUP00000024705	ENSMAUP00000021562	Actin, alpha cardiac muscle 1.	Myosin light polypeptide 6 isoform X2.	0.744
Actc1	Myl6b	ENSMAUP00000024705	ENSMAUP00000022473	Actin, alpha cardiac muscle 1.	Myosin light chain 6B.	0.791
Actc1	Myo15	ENSMAUP00000024705	ENSMAUP00000018396	Actin, alpha cardiac muscle 1.	Unconventional myosin-XV; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.678
Actc1	Myo15b	ENSMAUP00000024705	ENSMAUP00000019432	Actin, alpha cardiac muscle 1.	Myosin XVB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.544

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