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Sod2 Sod2 Pdcd4 Pdcd4 Apoh Apoh Rbm10 Rbm10 Lypd3 Lypd3 Lrp6 Lrp6 Mfn2 Mfn2 Sirt1 Sirt1 Dipk2a Dipk2a Il12a Il12a Cdkn2a Cdkn2a Atf4 Atf4 Pparg Pparg Arrb2 Arrb2 Cftr Cftr Gsk3b Gsk3b Edn1 Edn1 Gria4 Gria4 Ccdc142 Ccdc142 Stk4 Stk4 Dnmt1 Dnmt1 E2f3 E2f3 Slc7a5 Slc7a5 Igf1 Igf1 Arrb1 Arrb1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
Pdcd4Programmed cell death protein 4. (469 aa)
ApohBeta-2-glycoprotein 1. (297 aa)
Rbm10RNA-binding protein 10 isoform X5. (931 aa)
Lypd3ly6/PLAUR domain-containing protein 3. (351 aa)
Lrp6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1601 aa)
Mfn2Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
Sirt1NAD-dependent protein deacetylase sirtuin-1. (691 aa)
Dipk2aDeleted in autism protein 1. (430 aa)
Il12aInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (206 aa)
Cdkn2aCyclin-dependent kinase inhibitor 2A. (157 aa)
Atf4Cyclic AMP-dependent transcription factor ATF-4. (350 aa)
PpargPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (217 aa)
Arrb2Beta-arrestin-2. (279 aa)
CftrCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1184 aa)
Gsk3bGlycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (429 aa)
Edn1Endothelin-1. (202 aa)
Gria4Glutamate receptor 4 isoform X2. (433 aa)
Ccdc142Coiled-coil domain-containing protein 142. (734 aa)
Stk4Serine/threonine-protein kinase 4. (448 aa)
Dnmt1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1599 aa)
E2f3Transcription factor E2F3 isoform X1. (460 aa)
Slc7a5Large neutral amino acids transporter small subunit 1. (506 aa)
Igf1Insulin-like growth factor 1. (153 aa)
Arrb1Beta-arrestin-1 isoform X3. (418 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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