STRINGSTRING
Smad3 Smad3 Adcyap1 Adcyap1 Tspo Tspo Hhex Hhex Nf1 Nf1 Cdk6 Cdk6 Srd5a1 Srd5a1 Rbpj Rbpj Sox9 Sox9 Ascl1 Ascl1 Vhl Vhl Nr3c1 Nr3c1 Nkx2-1 Nkx2-1 Pbx1 Pbx1 Dkk3 Dkk3 Pax1 Pax1 Tbx1 Tbx1 Nkx6-1 Nkx6-1 Sall1 Sall1 Pdgfra Pdgfra Inhbb Inhbb Six1 Six1 Kdm1a Kdm1a Bmp5 Bmp5 Tbx19 Tbx19 Hoxd3 Hoxd3 Bak1 Bak1 Creb1 Creb1 Srf Srf Myt1 Myt1 Apoa1 Apoa1 Cdkn1c Cdkn1c Onecut1 Onecut1 LOC101835497 LOC101835497 Il6 Il6 Mapk1 Mapk1 Sox2 Sox2 Hmga2 Hmga2 Crkl Crkl Ednra Ednra Crhr1 Crhr1 Crh Crh Shh Shh Lhx3 Lhx3 Foxa2 Foxa2 Fgf8 Fgf8 Mnx1 Mnx1 Gata3 Gata3 Bmpr1a Bmpr1a Edn1 Edn1 Aldh1a2 Aldh1a2 Braf Braf Neurod1 Neurod1 Cdh1 Cdh1 Bmp2 Bmp2 Gcm2 Gcm2 Duox2 Duox2 Cdh2 Cdh2 Fgf2 Fgf2 Wnt5a Wnt5a Sidt2 Sidt2 Men1 Men1 Ly6e Ly6e Tcf7l2 Tcf7l2 Gsx1 Gsx1 Prop1 Prop1 Pax4 Pax4 Tgfbr1 Tgfbr1 Hes1 Hes1 Cyp1b1 Cyp1b1 Dll1 Dll1 Mapk3 Mapk3 Pdgfrb Pdgfrb Fgf10 Fgf10 Six3 Six3 Gdf11 Gdf11 Map2k2 Map2k2 Pcsk1 Pcsk1 Map2k1 Map2k1 Wnt4 Wnt4 Hoxb3 Hoxb3 Bmp6 Bmp6 Nr5a1 Nr5a1 Drd2 Drd2 Il6r Il6r Gli1 Gli1 Neurog3 Neurog3 Igf1r Igf1r Pou3f2 Pou3f2 Smo Smo Rfx3 Rfx3 Anxa1 Anxa1 Isl1 Isl1 Smad4 Smad4 Onecut2 Onecut2 Hnf1b Hnf1b Pax6 Pax6 Thra Thra Gip Gip Stra6 Stra6 Arid5b Arid5b Gli2 Gli2 Insm1 Insm1 Nog Nog Wnt11 Wnt11 Pdpk1 Pdpk1 Wt1 Wt1 Hnf4a Hnf4a Pou1f1 Pou1f1 Otp Otp Nkx2-5 Nkx2-5 Gata2 Gata2 Pitx1 Pitx1 Mdk Mdk Smad2 Smad2 Armc5 Armc5 Pax8 Pax8 Nkx6-2 Nkx6-2 Gata6 Gata6 Cited2 Cited2 Rfx6 Rfx6 ENSMAUP00000002638 ENSMAUP00000002638 Hoxa5 Hoxa5 Bmp4 Bmp4 Sox4 Sox4 Hoxa3 Hoxa3 Nr0b1 Nr0b1 Eif2ak3 Eif2ak3 Pitx2 Pitx2 Hesx1 Hesx1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Smad3Mothers against decapentaplegic homolog. (425 aa)
Adcyap1Pituitary adenylate cyclase-activating polypeptide isoform X1. (175 aa)
TspoTranslocator protein. (169 aa)
HhexHematopoietically-expressed homeobox protein HHEX. (271 aa)
Nf1Neurofibromin. (2400 aa)
Cdk6Cyclin-dependent kinase 6. (203 aa)
Srd5a13-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (255 aa)
RbpjRecombining binding protein suppressor of hairless isoform X1. (526 aa)
Sox9Transcription factor SOX-9. (507 aa)
Ascl1Achaete-scute homolog 1. (234 aa)
VhlVon Hippel-Lindau disease tumor suppressor isoform X2. (184 aa)
Nr3c1Glucocorticoid receptor isoform X2. (382 aa)
Nkx2-1Homeobox protein Nkx-2.1 isoform X2. (372 aa)
Pbx1pre-B-cell leukemia transcription factor 1 isoform X1. (430 aa)
Dkk3Dickkopf-related protein 3. (348 aa)
Pax1Paired box protein Pax-1. (449 aa)
Tbx1T-box transcription factor TBX1. (464 aa)
Nkx6-1Homeobox protein Nkx-6.1; Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity). Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. (217 aa)
Sall1Sal-like protein 1. (1318 aa)
PdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
InhbbInhibin beta B chain. (411 aa)
Six1Homeobox protein SIX1. (284 aa)
Kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (870 aa)
Bmp5Bone morphogenetic protein 5. (454 aa)
Tbx19T-box transcription factor TBX19. (447 aa)
Hoxd3Homeobox protein Hox-D3. (432 aa)
Bak1Bcl-2 homologous antagonist/killer. (209 aa)
Creb1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
SrfSerum response factor isoform X1. (509 aa)
Myt1Myelin transcription factor 1 isoform X1. (1176 aa)
Apoa1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. (264 aa)
Cdkn1cCyclin-dependent kinase inhibitor 1C isoform X2. (348 aa)
Onecut1One cut domain family member. (465 aa)
LOC101835497Lymphocyte antigen 6E-like. (136 aa)
Il6Interleukin-6. (212 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa)
Sox2Transcription factor SOX-2. (319 aa)
Hmga2High mobility group protein HMGI-C isoform X1. (108 aa)
CrklCrk-like protein. (303 aa)
EdnraEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
Crhr1Type-1 corticotropin-releasing hormone receptor alpha isoform; Belongs to the G-protein coupled receptor 2 family. (415 aa)
CrhCorticoliberin. (187 aa)
ShhHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (439 aa)
Lhx3LIM/homeobox protein Lhx3 isoform X1. (403 aa)
Foxa2Hepatocyte nuclear factor 3-beta isoform X2. (460 aa)
Fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
Mnx1Motor neuron and pancreas homeobox protein 1. (360 aa)
Gata3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (443 aa)
Bmpr1aReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
Edn1Endothelin-1. (202 aa)
Aldh1a2Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. (518 aa)
BrafSerine/threonine-protein kinase B-raf. (710 aa)
Neurod1Neurogenic differentiation factor 1; Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or [...] (355 aa)
Cdh1Cadherin-1 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (886 aa)
Bmp2Bone morphogenetic protein 2 isoform X1. (394 aa)
Gcm2Chorion-specific transcription factor GCMb. (503 aa)
Duox2Dual oxidase 2. (1306 aa)
Cdh2Cadherin-2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
Fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
Wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
Sidt2SID1 transmembrane family member 2 isoform X1. (853 aa)
Men1Menin isoform X2. (610 aa)
Ly6eLymphocyte antigen 6E-like. (136 aa)
Tcf7l2Transcription factor 7-like 2 isoform X17. (598 aa)
Gsx1GS homeobox 1. (265 aa)
Prop1Homeobox protein prophet of Pit-1. (223 aa)
Pax4Paired box protein Pax-4. (356 aa)
Tgfbr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
Hes1Transcription factor HES-1. (281 aa)
Cyp1b1Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (541 aa)
Dll1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (733 aa)
Mapk3Mitogen-activated protein kinase. (380 aa)
PdgfrbPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (703 aa)
Fgf10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
Six3Homeobox protein SIX3. (279 aa)
Gdf11Growth/differentiation factor 11. (389 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
Pcsk1Proprotein convertase subtilisin/kexin type 1. (607 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
Wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
Hoxb3Homeobox protein Hox-B3. (429 aa)
Bmp6Bone morphogenetic protein 6. (502 aa)
Nr5a1Steroidogenic factor 1. (252 aa)
Drd2D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (444 aa)
Il6rInterleukin-6 receptor subunit alpha. (460 aa)
Gli1Zinc finger protein GLI1. (981 aa)
Neurog3Neurogenin-3. (214 aa)
Igf1rTyrosine-protein kinase receptor. (1154 aa)
Pou3f2POU domain protein. (445 aa)
SmoSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (757 aa)
Rfx3Transcription factor RFX3 isoform X2. (749 aa)
Anxa1Annexin. (346 aa)
Isl1Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for [...] (349 aa)
Smad4Mothers against decapentaplegic homolog. (552 aa)
Onecut2One cut domain family member. (433 aa)
Hnf1bHepatocyte nuclear factor 1-beta isoform X1. (558 aa)
Pax6Paired box protein Pax-6 isoform X1. (436 aa)
ThraThyroid hormone receptor alpha. (491 aa)
GipGastric inhibitory polypeptide. (141 aa)
Stra6Stimulated by retinoic acid gene 6 protein homolog. (671 aa)
Arid5bAT-rich interactive domain-containing protein 5B isoform X1. (1189 aa)
Gli2Zinc finger protein GLI2. (1544 aa)
Insm1Insulinoma-associated protein 1. (517 aa)
NogNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
Wnt11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
Pdpk13-phosphoinositide-dependent protein kinase 1 isoform X2. (559 aa)
Wt1Wilms tumor protein isoform X2. (516 aa)
Hnf4aHepatocyte nuclear factor 4-alpha. (456 aa)
Pou1f1Pituitary-specific positive transcription factor 1. (227 aa)
OtpHomeobox protein orthopedia. (325 aa)
Nkx2-5Homeobox protein Nkx-2.5. (317 aa)
Gata2Endothelial transcription factor GATA-2. (480 aa)
Pitx1Homeobox protein. (314 aa)
MdkMidkine. (143 aa)
Smad2Mothers against decapentaplegic homolog. (467 aa)
Armc5Armadillo repeat-containing protein 5. (926 aa)
Pax8Paired box protein Pax-8 isoform X2. (457 aa)
Nkx6-2Homeobox protein Nkx-6.2. (277 aa)
Gata6Transcription factor GATA-6. (442 aa)
Cited2Cbp/p300-interacting transactivator 2. (269 aa)
Rfx6DNA-binding protein RFX6. (926 aa)
ENSMAUP00000002638annotation not available (153 aa)
Hoxa5Homeobox protein Hox-A5. (271 aa)
Bmp4Bone morphogenetic protein 4. (409 aa)
Sox4Transcription factor SOX. (439 aa)
Hoxa3Homeobox protein Hox-A3. (445 aa)
Nr0b1Nuclear receptor subfamily 0 group B member 1. (476 aa)
Eif2ak3Eukaryotic translation initiation factor 2-alpha kinase 3. (1095 aa)
Pitx2Homeobox protein. (324 aa)
Hesx1Homeobox expressed in ES cells 1. (185 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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