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Pdss1 Pdss1 Afmid Afmid Cyp21a1 Cyp21a1 Dhrs9 Dhrs9 Stard3 Stard3 Ubiad1 Ubiad1 Sirt6 Sirt6 Srd5a1 Srd5a1 Coq4 Coq4 Kyat3 Kyat3 ENSMAUP00000023469 ENSMAUP00000023469 Coq8b Coq8b Scp2 Scp2 Glo1 Glo1 Kyat1 Kyat1 Hsd11b2 Hsd11b2 Ido2 Ido2 Fdxr Fdxr ENSMAUP00000021079 ENSMAUP00000021079 Hsd17b3 Hsd17b3 Got2 Got2 LOC101843311 LOC101843311 Cbr4 Cbr4 Akr1c14 Akr1c14 Cacna1h Cacna1h Coq8a Coq8a Srd5a2 Srd5a2 Gatd1 Gatd1 Akr1c18 Akr1c18 Tdo2 Tdo2 Aadat Aadat Cyp17a1 Cyp17a1 Park7 Park7 Ednrb Ednrb Cyp19a1 Cyp19a1 LOC101830409 LOC101830409 Coq2-2 Coq2-2 Cyp46a1 Cyp46a1 Afp Afp Dhrs4 Dhrs4 Coq2 Coq2 Coq3 Coq3 Pnkd Pnkd Kynu Kynu Hsd17b10 Hsd17b10 Hagh Hagh Gpd1 Gpd1 Aldoa Aldoa Coq6 Coq6 Ido1 Ido1 Coq10a Coq10a Coq10b Coq10b Kdsr Kdsr Coq9 Coq9 Cryzl1 Cryzl1 Aifm2 Aifm2 Akr1b1 Akr1b1 Vkorc1l1 Vkorc1l1 ENSMAUP00000006970 ENSMAUP00000006970 Cyp4f14 Cyp4f14 Haghl Haghl Nqo1 Nqo1 ENSMAUP00000006531 ENSMAUP00000006531 Coq5 Coq5 Nmt1 Nmt1 Pdss2 Pdss2 Tpi1 Tpi1 LOC101840628 LOC101840628 LOC101843587 LOC101843587 Hsd17b1 Hsd17b1 Cyp4f40 Cyp4f40 LOC101839651 LOC101839651 LOC101835654 LOC101835654 Adh4 Adh4 Nqo2 Nqo2 LOC106021445 LOC106021445 Kmo Kmo Coq7 Coq7 Ndufa9 Ndufa9 Cbr3 Cbr3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Pdss1Decaprenyl-diphosphate synthase subunit 1; Belongs to the FPP/GGPP synthase family. (407 aa)
AfmidKynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (311 aa)
Cyp21a1Steroid 21-hydroxylase isoform X2; Belongs to the cytochrome P450 family. (496 aa)
Dhrs9Dehydrogenase/reductase SDR family member 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (322 aa)
Stard3stAR-related lipid transfer protein 3. (442 aa)
Ubiad1ubiA prenyltransferase domain-containing protein 1. (338 aa)
Sirt6NAD-dependent protein deacetylase sirtuin-6 isoform X1. (334 aa)
Srd5a13-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (255 aa)
Coq4Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. (284 aa)
Kyat3Kynurenine--oxoglutarate transaminase 3. (379 aa)
ENSMAUP00000023469annotation not available (143 aa)
Coq8bAtypical kinase COQ8B, mitochondrial. (517 aa)
Scp2Non-specific lipid-transfer protein isoform X2; Belongs to the thiolase-like superfamily. Thiolase family. (231 aa)
Glo1Lactoylglutathione lyase. (184 aa)
Kyat1Kynurenine--oxoglutarate transaminase 1 isoform X3. (458 aa)
Hsd11b2Corticosteroid 11-beta-dehydrogenase isozyme 2. (401 aa)
Ido2Indoleamine 2,3-dioxygenase 2 isoform X1. (405 aa)
FdxrNADPH:adrenodoxin oxidoreductase, mitochondrial. (493 aa)
ENSMAUP00000021079annotation not available (162 aa)
Hsd17b3Testosterone 17-beta-dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (217 aa)
Got2Aspartate aminotransferase. (430 aa)
LOC1018433113-hydroxyhexobarbital dehydrogenase 1/3-alpha, 17-beta-hydroxysteroid dehydrogenase. (323 aa)
Cbr4Carbonyl reductase family member 4. (236 aa)
Akr1c143-alpha-hydroxysteroid dehydrogenase-like isoform X1. (323 aa)
Cacna1hVoltage-dependent T-type calcium channel subunit alpha-1H isoform X3. (147 aa)
Coq8aAtypical kinase COQ8A, mitochondrial. (649 aa)
Srd5a23-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (253 aa)
Gatd1Parkinson disease 7 domain-containing protein 1 isoform X2. (200 aa)
Akr1c18Aldo-keto reductase family 1 member C18 isoform X1. (323 aa)
Tdo2Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (407 aa)
AadatKynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform X1. (425 aa)
Cyp17a1Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] (431 aa)
Park7Protein/nucleic acid deglycase DJ-1, N-terminally processed; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hem [...] (188 aa)
EdnrbEndothelin B receptor; Belongs to the G-protein coupled receptor 1 family. (432 aa)
Cyp19a1Aromatase; Belongs to the cytochrome P450 family. (503 aa)
LOC101830409Probable hydrolase PNKD. (142 aa)
Coq2-2Coenzyme Q2, polyprenyltransferase. (44 aa)
Cyp46a1Cholesterol 24-hydroxylase; Belongs to the cytochrome P450 family. (500 aa)
AfpAlpha-fetoprotein. (609 aa)
Dhrs4Dehydrogenase/reductase SDR family member 4. (279 aa)
Coq24-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (211 aa)
Coq3Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (367 aa)
PnkdProbable hydrolase PNKD. (360 aa)
KynuKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (467 aa)
Hsd17b103-hydroxyacyl-CoA dehydrogenase type-2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
HaghHydroxyacylglutathione hydrolase, mitochondrial isoform X2. (260 aa)
Gpd1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
AldoaAldolase A, fructose-bisphosphate. (139 aa)
Coq6Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (471 aa)
Ido1Indoleamine 2,3-dioxygenase 1 isoform X1. (397 aa)
Coq10aCoenzyme Q-binding protein COQ10 homolog A, mitochondrial. (256 aa)
Coq10bCoenzyme Q-binding protein COQ10 homolog B, mitochondrial. (213 aa)
Kdsr3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (332 aa)
Coq9Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. (317 aa)
Cryzl1Quinone oxidoreductase-like protein 1 isoform X3. (333 aa)
Aifm2Apoptosis-inducing factor 2. (373 aa)
Akr1b1Aldose reductase. (316 aa)
Vkorc1l1Vitamin K epoxide reductase complex subunit 1-like protein 1 isoform X1. (176 aa)
ENSMAUP00000006970annotation not available (246 aa)
Cyp4f14leukotriene-B4 omega-hydroxylase 3 isoform X2; Belongs to the cytochrome P450 family. (524 aa)
HaghlHydroxyacylglutathione hydrolase-like protein. (235 aa)
Nqo1NAD(P)H dehydrogenase [quinone] 1. (275 aa)
ENSMAUP00000006531annotation not available (236 aa)
Coq52-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (327 aa)
Nmt1Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (504 aa)
Pdss2Decaprenyl-diphosphate synthase subunit 2; Belongs to the FPP/GGPP synthase family. (423 aa)
Tpi1Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. (249 aa)
LOC101840628Vitamin K epoxide reductase complex subunit 1. (94 aa)
LOC101843587Aldo-keto reductase family 1 member C21-like isoform X1. (319 aa)
Hsd17b1Estradiol 17-beta-dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (343 aa)
Cyp4f40Cytochrome P450 4F4-like; Belongs to the cytochrome P450 family. (532 aa)
LOC101839651Aldo-keto reductase family 1 member C21-like. (310 aa)
LOC101835654Signal transducer and activator of transcription. (228 aa)
Adh4Alcohol dehydrogenase 4. (377 aa)
Nqo2Ribosyldihydronicotinamide dehydrogenase [quinone]. (231 aa)
LOC106021445L-xylulose reductase-like isoform X1. (163 aa)
KmoKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (479 aa)
Coq75-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (216 aa)
Ndufa9NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial. (377 aa)
Cbr3Carbonyl reductase [NADPH] 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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