(52 nodes) Positive regulation of protein import into nucleus network (Mesocricetus auratus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	Smo	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (757 aa)
	Zic1	Zinc finger protein ZIC 1. (447 aa)
	Dmap1	DNA methyltransferase 1-associated protein 1. (468 aa)
	Rbm22	pre-mRNA-splicing factor RBM22. (420 aa)
	1700009N14Rik	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (216 aa)
	Tnfrsf1a	Tumor necrosis factor receptor superfamily member 1A. (468 aa)
	Tgfb1	Transforming growth factor beta-1. (286 aa)
	Psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	ENSMAUP00000004541	annotation not available (622 aa)
	LOC101825141	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (216 aa)
	Pik3r1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	ENSMAUP00000006643	annotation not available (1305 aa)
	Jak2	Tyrosine-protein kinase. (1132 aa)
	Ect2	Protein ECT2 isoform X1. (912 aa)
	ENSMAUP00000008492	annotation not available (391 aa)
	Gli3	Transcriptional activator GLI3. (1582 aa)
	Bag3	BAG family molecular chaperone regulator 3. (532 aa)
	Hdac3	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
	Efcab7	EF-hand calcium-binding domain-containing protein 7. (628 aa)
	Zc3h12a	Endoribonuclease ZC3H12A. (592 aa)
	Chp2	Calcineurin B homologous protein 2 isoform X2. (196 aa)
	Gper1	G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
	LOC101842052	filamin-A. (816 aa)
	Zpr1	Zinc finger protein ZPR1. (459 aa)
	Mavs	Mitochondrial antiviral-signaling protein isoform X1. (498 aa)
	Cdh1	Cadherin-1 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (886 aa)
	Ran	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (113 aa)
	Jup	Junction plakoglobin. (729 aa)
	Mapk14	Mitogen-activated protein kinase. (360 aa)
	LOC101837891	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (216 aa)
	Shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (439 aa)
	Ipo5	Importin-5. (1088 aa)
	Pik3r2	Phosphatidylinositol 3-kinase regulatory subunit beta isoform X2. (488 aa)
	Ptpn5	Tyrosine-protein phosphatase non-receptor type 5. (541 aa)
	Mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa)
	Trim28	Transcription intermediary factor 1-beta. (822 aa)
	Il6	Interleukin-6. (212 aa)
	Tardbp	TAR DNA-binding protein 43 isoform X1. (414 aa)
	Uaca	Uveal autoantigen with coiled-coil domains and ankyrin repeats isoform X1. (1410 aa)
	Hsp90ab1	Heat shock protein HSP 90-beta. (724 aa)
	Tek	Angiopoietin-1 receptor. (1039 aa)
	Ptgs2	Prostaglandin G/H synthase 2. (604 aa)
	Ubr5	E3 ubiquitin-protein ligase UBR5 isoform X2. (2798 aa)
	Prkcq	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (707 aa)
	Cdk1	Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. (297 aa)
	Lep	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	Hyal2	Hyaluronidase. (473 aa)
	Pik3r2-2	Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
	Tpr	Nucleoprotein TPR. (2434 aa)
	Prkcd	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
	ENSMAUP00000025679	annotation not available (108 aa)
	Prkd1	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (918 aa)

Your Current Organism:

Mesocricetus auratus

NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
1700009N14Rik	Ipo5	ENSMAUP00000002257	ENSMAUP00000017837	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	Importin-5.	0.720
1700009N14Rik	LOC101825141	ENSMAUP00000002257	ENSMAUP00000006035	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.678
1700009N14Rik	LOC101837891	ENSMAUP00000002257	ENSMAUP00000016992	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.683
1700009N14Rik	Ran	ENSMAUP00000002257	ENSMAUP00000016553	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.678
1700009N14Rik	Tpr	ENSMAUP00000002257	ENSMAUP00000024450	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	Nucleoprotein TPR.	0.648
Bag3	ENSMAUP00000004541	ENSMAUP00000009146	ENSMAUP00000004541	BAG family molecular chaperone regulator 3.	annotation not available	0.500
Bag3	ENSMAUP00000008492	ENSMAUP00000009146	ENSMAUP00000008492	BAG family molecular chaperone regulator 3.	annotation not available	0.500
Bag3	ENSMAUP00000025679	ENSMAUP00000009146	ENSMAUP00000025679	BAG family molecular chaperone regulator 3.	annotation not available	0.500
Bag3	Hsp90ab1	ENSMAUP00000009146	ENSMAUP00000020398	BAG family molecular chaperone regulator 3.	Heat shock protein HSP 90-beta.	0.500
Bag3	Jak2	ENSMAUP00000009146	ENSMAUP00000006704	BAG family molecular chaperone regulator 3.	Tyrosine-protein kinase.	0.574
Bag3	Pik3r1	ENSMAUP00000009146	ENSMAUP00000006214	BAG family molecular chaperone regulator 3.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.531
Bag3	Pik3r2	ENSMAUP00000009146	ENSMAUP00000018310	BAG family molecular chaperone regulator 3.	Phosphatidylinositol 3-kinase regulatory subunit beta isoform X2.	0.531
Bag3	Pik3r2-2	ENSMAUP00000009146	ENSMAUP00000024230	BAG family molecular chaperone regulator 3.	Phosphoinositide-3-kinase regulatory subunit 2.	0.531
Bag3	Tnfrsf1a	ENSMAUP00000009146	ENSMAUP00000002935	BAG family molecular chaperone regulator 3.	Tumor necrosis factor receptor superfamily member 1A.	0.709
Cdh1	Ect2	ENSMAUP00000015917	ENSMAUP00000007842	Cadherin-1 isoform X1; Cadherins are calcium-dependent cell adhesion proteins.	Protein ECT2 isoform X1.	0.428
Cdh1	Jup	ENSMAUP00000015917	ENSMAUP00000016879	Cadherin-1 isoform X1; Cadherins are calcium-dependent cell adhesion proteins.	Junction plakoglobin.	0.998
Cdh1	Mapk14	ENSMAUP00000015917	ENSMAUP00000016953	Cadherin-1 isoform X1; Cadherins are calcium-dependent cell adhesion proteins.	Mitogen-activated protein kinase.	0.414
Cdh1	Psen1	ENSMAUP00000015917	ENSMAUP00000003621	Cadherin-1 isoform X1; Cadherins are calcium-dependent cell adhesion proteins.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.882
Cdh1	Tgfb1	ENSMAUP00000015917	ENSMAUP00000003471	Cadherin-1 isoform X1; Cadherins are calcium-dependent cell adhesion proteins.	Transforming growth factor beta-1.	0.470
Cdk1	ENSMAUP00000004541	ENSMAUP00000023040	ENSMAUP00000004541	Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily.	annotation not available	0.511

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