node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Akr1c14 | Cyp17a1 | ENSMAUP00000019562 | ENSMAUP00000015990 | 3-alpha-hydroxysteroid dehydrogenase-like isoform X1. | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.861 |
Akr1c14 | Cyp21a1 | ENSMAUP00000019562 | ENSMAUP00000025484 | 3-alpha-hydroxysteroid dehydrogenase-like isoform X1. | Steroid 21-hydroxylase isoform X2; Belongs to the cytochrome P450 family. | 0.596 |
Akr1c14 | Dhrs9 | ENSMAUP00000019562 | ENSMAUP00000025396 | 3-alpha-hydroxysteroid dehydrogenase-like isoform X1. | Dehydrogenase/reductase SDR family member 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.433 |
Akr1c14 | LOC101839651 | ENSMAUP00000019562 | ENSMAUP00000002398 | 3-alpha-hydroxysteroid dehydrogenase-like isoform X1. | Aldo-keto reductase family 1 member C21-like. | 0.673 |
Akr1c14 | LOC101843311 | ENSMAUP00000019562 | ENSMAUP00000019812 | 3-alpha-hydroxysteroid dehydrogenase-like isoform X1. | 3-hydroxyhexobarbital dehydrogenase 1/3-alpha, 17-beta-hydroxysteroid dehydrogenase. | 0.689 |
Akr1c14 | LOC101843587 | ENSMAUP00000019562 | ENSMAUP00000003556 | 3-alpha-hydroxysteroid dehydrogenase-like isoform X1. | Aldo-keto reductase family 1 member C21-like isoform X1. | 0.673 |
Akr1c14 | Srd5a1 | ENSMAUP00000019562 | ENSMAUP00000024008 | 3-alpha-hydroxysteroid dehydrogenase-like isoform X1. | 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). | 0.897 |
Akr1c18 | Cyp17a1 | ENSMAUP00000017842 | ENSMAUP00000015990 | Aldo-keto reductase family 1 member C18 isoform X1. | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.811 |
Akr1c18 | Cyp21a1 | ENSMAUP00000017842 | ENSMAUP00000025484 | Aldo-keto reductase family 1 member C18 isoform X1. | Steroid 21-hydroxylase isoform X2; Belongs to the cytochrome P450 family. | 0.782 |
Akr1c18 | Dhrs9 | ENSMAUP00000017842 | ENSMAUP00000025396 | Aldo-keto reductase family 1 member C18 isoform X1. | Dehydrogenase/reductase SDR family member 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.415 |
Akr1c18 | LOC101839651 | ENSMAUP00000017842 | ENSMAUP00000002398 | Aldo-keto reductase family 1 member C18 isoform X1. | Aldo-keto reductase family 1 member C21-like. | 0.566 |
Akr1c18 | LOC101843311 | ENSMAUP00000017842 | ENSMAUP00000019812 | Aldo-keto reductase family 1 member C18 isoform X1. | 3-hydroxyhexobarbital dehydrogenase 1/3-alpha, 17-beta-hydroxysteroid dehydrogenase. | 0.686 |
Akr1c18 | LOC101843587 | ENSMAUP00000017842 | ENSMAUP00000003556 | Aldo-keto reductase family 1 member C18 isoform X1. | Aldo-keto reductase family 1 member C21-like isoform X1. | 0.566 |
Akr1c18 | Srd5a1 | ENSMAUP00000017842 | ENSMAUP00000024008 | Aldo-keto reductase family 1 member C18 isoform X1. | 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). | 0.835 |
Cyp17a1 | Akr1c14 | ENSMAUP00000015990 | ENSMAUP00000019562 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 3-alpha-hydroxysteroid dehydrogenase-like isoform X1. | 0.861 |
Cyp17a1 | Akr1c18 | ENSMAUP00000015990 | ENSMAUP00000017842 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Aldo-keto reductase family 1 member C18 isoform X1. | 0.811 |
Cyp17a1 | Cyp21a1 | ENSMAUP00000015990 | ENSMAUP00000025484 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Steroid 21-hydroxylase isoform X2; Belongs to the cytochrome P450 family. | 0.897 |
Cyp17a1 | Dhrs9 | ENSMAUP00000015990 | ENSMAUP00000025396 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Dehydrogenase/reductase SDR family member 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.671 |
Cyp17a1 | LOC101839651 | ENSMAUP00000015990 | ENSMAUP00000002398 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Aldo-keto reductase family 1 member C21-like. | 0.698 |
Cyp17a1 | LOC101843311 | ENSMAUP00000015990 | ENSMAUP00000019812 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 3-hydroxyhexobarbital dehydrogenase 1/3-alpha, 17-beta-hydroxysteroid dehydrogenase. | 0.855 |