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Reln Reln Cacna1e Cacna1e Tspo Tspo Osm Osm Thbs1 Thbs1 Trpa1 Trpa1 Ucn Ucn Tacr1 Tacr1 Crhr1 Crhr1 Crh Crh Runx1-2 Runx1-2 Mtor Mtor Ednrb Ednrb P2rx3 P2rx3 Runx1 Runx1 Comt Comt Akt1 Akt1 Dbh Dbh Capn2 Capn2 P2rx2 P2rx2 Gch1 Gch1 Git2 Git2 Grin2b Grin2b Kcnip3 Kcnip3 Thbs4 Thbs4 Cacna1b Cacna1b Lyl1 Lyl1 Trpv1 Trpv1 Scn9a Scn9a Ntrk1 Ntrk1 Gja4 Gja4 Slc6a2 Slc6a2 Ret Ret Vwa1 Vwa1 Pirt Pirt Calca Calca Nmur2 Nmur2 Prkcg Prkcg Grik1 Grik1 Tac1 Tac1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RelnReelin isoform X2. (3258 aa)
Cacna1eVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2237 aa)
TspoTranslocator protein. (169 aa)
Osmoncostatin-M isoform X2. (240 aa)
Thbs1Thrombospondin-1 isoform X1. (1171 aa)
Trpa1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1081 aa)
UcnUrocortin. (122 aa)
Tacr1substance-P receptor; Belongs to the G-protein coupled receptor 1 family. (407 aa)
Crhr1Type-1 corticotropin-releasing hormone receptor alpha isoform; Belongs to the G-protein coupled receptor 2 family. (415 aa)
CrhCorticoliberin. (187 aa)
Runx1-2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (62 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
EdnrbEndothelin B receptor; Belongs to the G-protein coupled receptor 1 family. (432 aa)
P2rx3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (397 aa)
Runx1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (68 aa)
ComtCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (264 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
DbhDopamine beta-hydroxylase. (620 aa)
Capn2Calpain-2 catalytic subunit; Belongs to the peptidase C2 family. (725 aa)
P2rx2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (414 aa)
Gch1GTP cyclohydrolase 1 isoform X2. (242 aa)
Git2ARF GTPase-activating protein GIT2 isoform X10. (632 aa)
Grin2bGlutamate receptor ionotropic, NMDA 2B. (1483 aa)
Kcnip3Calsenilin isoform X3. (259 aa)
Thbs4Thrombospondin-4. (867 aa)
Cacna1bVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2331 aa)
Lyl1Voltage-dependent P/Q-type calcium channel subunit alpha-1A. (2248 aa)
Trpv1Transient receptor potential cation channel subfamily V member 1 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (472 aa)
Scn9aSodium channel protein type 9 subunit alpha. (1384 aa)
Ntrk1Tyrosine-protein kinase receptor. (799 aa)
Gja4Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (333 aa)
Slc6a2Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (617 aa)
RetProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
Vwa1Von Willebrand factor A domain-containing protein 1. (406 aa)
PirtPhosphoinositide-interacting protein. (135 aa)
CalcaCalcitonin. (136 aa)
Nmur2neuromedin-U receptor 2; Belongs to the G-protein coupled receptor 1 family. (394 aa)
PrkcgProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (612 aa)
Grik1Glutamate receptor ionotropic, kainate 1 isoform X2. (934 aa)
Tac1C-terminal-flanking peptide; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles; Belongs to the tachykinin family. (130 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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