STRINGSTRING
Smad4 Smad4 Prox1 Prox1 Bmpr2 Bmpr2 Parva Parva LOC101830678 LOC101830678 Nog Nog Wnt11 Wnt11 Mks1 Mks1 Lrp2 Lrp2 Nkx2-5 Nkx2-5 Tbx20 Tbx20 Rbm15 Rbm15 Nrp1 Nrp1 Ccn1 Ccn1 Tbx2 Tbx2 Gata6 Gata6 Cited2 Cited2 Tbx5 Tbx5 Tgfbr2 Tgfbr2 ENSMAUP00000002507 ENSMAUP00000002507 Bmp4 Bmp4 Sox4 Sox4 Aplnr Aplnr Chd7 Chd7 Fzd1 Fzd1 Robo2 Robo2 Pitx2 Pitx2 Fzd2 Fzd2 Heyl Heyl Eng Eng Nrp2 Nrp2 Rbpj Rbpj Smad7 Smad7 Slit3 Slit3 Egln1 Egln1 Tbx1 Tbx1 Zfpm2 Zfpm2 Dvl3 Dvl3 Bmp5 Bmp5 Sav1 Sav1 LOC101837667 LOC101837667 Cfc1 Cfc1 Hey1 Hey1 Fgfrl1 Fgfrl1 Zfpm1 Zfpm1 Tgfbr3 Tgfbr3 Tbx3 Tbx3 Vangl2 Vangl2 Nos3 Nos3 Sox11 Sox11 Gja5 Gja5 Notch2 Notch2 Fgf8 Fgf8 Bmpr1a Bmpr1a Nsd2 Nsd2 Jag1 Jag1 Bmp7 Bmp7 Dhrs3 Dhrs3 Wnt5a Wnt5a Gata4 Gata4 Ift88 Ift88 Nfatc1 Nfatc1 Sema3c Sema3c Tgfbr1 Tgfbr1 Hes1 Hes1 Id2 Id2 Fgfr2 Fgfr2 Msx2 Msx2 Slit2 Slit2 Hey2 Hey2 Dnah11 Dnah11 Smo Smo Tgfb2 Tgfb2 Smad6 Smad6 Isl1 Isl1 Robo1 Robo1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Smad4Mothers against decapentaplegic homolog. (552 aa)
Prox1Prospero homeobox protein 1 isoform X2. (734 aa)
Bmpr2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (832 aa)
ParvaAlpha-parvin. (342 aa)
LOC101830678Roundabout homolog 2-like. (145 aa)
NogNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
Wnt11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
Mks1Meckel syndrome type 1 protein isoform X2. (266 aa)
Lrp2Low-density lipoprotein receptor-related protein 2. (4244 aa)
Nkx2-5Homeobox protein Nkx-2.5. (317 aa)
Tbx20T-box transcription factor TBX20. (445 aa)
Rbm15Putative RNA-binding protein 15. (961 aa)
Nrp1Neuropilin; Belongs to the neuropilin family. (910 aa)
Ccn1Protein CYR61. (378 aa)
Tbx2T-box transcription factor TBX2. (714 aa)
Gata6Transcription factor GATA-6. (442 aa)
Cited2Cbp/p300-interacting transactivator 2. (269 aa)
Tbx5T-box transcription factor TBX5. (518 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ENSMAUP00000002507annotation not available (120 aa)
Bmp4Bone morphogenetic protein 4. (409 aa)
Sox4Transcription factor SOX. (439 aa)
AplnrApelin receptor; Belongs to the G-protein coupled receptor 1 family. (377 aa)
Chd7chromodomain-helicase-DNA-binding protein 7 isoform X1. (2916 aa)
Fzd1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
Robo2Roundabout homolog 2. (1257 aa)
Pitx2Homeobox protein. (324 aa)
Fzd2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (567 aa)
HeylHairy/enhancer-of-split related with YRPW motif-like protein isoform X1. (328 aa)
EngEndoglin. (589 aa)
Nrp2Neuropilin; Belongs to the neuropilin family. (931 aa)
RbpjRecombining binding protein suppressor of hairless isoform X1. (526 aa)
Smad7Mothers against decapentaplegic homolog. (427 aa)
Slit3Slit homolog 3 protein. (1443 aa)
Egln1Egl nine homolog 1. (126 aa)
Tbx1T-box transcription factor TBX1. (464 aa)
Zfpm2Zinc finger protein ZFPM2 isoform X1. (1156 aa)
Dvl3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (718 aa)
Bmp5Bone morphogenetic protein 5. (454 aa)
Sav1Protein salvador homolog 1. (387 aa)
LOC101837667Activin receptor type-1. (107 aa)
Cfc1Cryptic protein-like. (166 aa)
Hey1Hairy/enhancer-of-split related with YRPW motif protein 1. (278 aa)
Fgfrl1Fibroblast growth factor receptor-like 1 isoform X1. (533 aa)
Zfpm1Zinc finger protein ZFPM1 isoform X1. (997 aa)
Tgfbr3Transforming growth factor beta receptor type 3. (741 aa)
Tbx3T-box transcription factor TBX3. (130 aa)
Vangl2Vang-like protein. (320 aa)
Nos3Nitric oxide synthase; Produces nitric oxide (NO). (1202 aa)
Sox11Transcription factor SOX. (395 aa)
Gja5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
Notch2Neurogenic locus notch homolog protein 2. (2470 aa)
Fgf8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
Bmpr1aReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
Nsd2Histone-lysine N-methyltransferase NSD2. (1367 aa)
Jag1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
Bmp7Bone morphogenetic protein 7. (430 aa)
Dhrs3Short-chain dehydrogenase/reductase 3 isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
Wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
Gata4Transcription factor GATA-4 isoform X2. (443 aa)
Ift88Intraflagellar transport protein 88 homolog. (794 aa)
Nfatc1Nuclear factor of activated T-cells, cytoplasmic 1. (898 aa)
Sema3csemaphorin-3C; Belongs to the semaphorin family. (752 aa)
Tgfbr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
Hes1Transcription factor HES-1. (281 aa)
Id2DNA-binding protein inhibitor ID-2. (134 aa)
Fgfr2Fibroblast growth factor receptor. (784 aa)
Msx2Homeobox protein MSX-2. (267 aa)
Slit2Slit homolog 2 protein. (1494 aa)
Hey2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
Dnah11Dynein heavy chain 11, axonemal. (4344 aa)
SmoSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (757 aa)
Tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
Smad6Mothers against decapentaplegic homolog. (496 aa)
Isl1Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for [...] (349 aa)
Robo1Roundabout homolog 1. (1498 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.