STRINGSTRING
Smo Smo Hey2 Hey2 Gata4 Gata4 Nsd2 Nsd2 Notch2 Notch2 Gja5 Gja5 Zfpm1 Zfpm1 Ccn1 Ccn1 Tbx5 Tbx5 Sox4 Sox4 Tgfb2 Tgfb2 Isl1 Isl1 Bmpr2 Bmpr2 Nkx2-5 Nkx2-5 Tbx20 Tbx20 LOC101837667 LOC101837667 Cfc1 Cfc1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SmoSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (757 aa)
Hey2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
Gata4Transcription factor GATA-4 isoform X2. (443 aa)
Nsd2Histone-lysine N-methyltransferase NSD2. (1367 aa)
Notch2Neurogenic locus notch homolog protein 2. (2470 aa)
Gja5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
Zfpm1Zinc finger protein ZFPM1 isoform X1. (997 aa)
Ccn1Protein CYR61. (378 aa)
Tbx5T-box transcription factor TBX5. (518 aa)
Sox4Transcription factor SOX. (439 aa)
Tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
Isl1Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for [...] (349 aa)
Bmpr2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (832 aa)
Nkx2-5Homeobox protein Nkx-2.5. (317 aa)
Tbx20T-box transcription factor TBX20. (445 aa)
LOC101837667Activin receptor type-1. (107 aa)
Cfc1Cryptic protein-like. (166 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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