STRINGSTRING
Cflar Cflar Casp8 Casp8 Casp14 Casp14 Casp9 Casp9 Casp2 Casp2 Casp6 Casp6 Casp7 Casp7 Casp1 Casp1 Casp3 Casp3 Malt1 Malt1 Casp16 Casp16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CflarCASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (219 aa)
Casp8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (481 aa)
Casp14Caspase-14; Belongs to the peptidase C14A family. (246 aa)
Casp9Caspase-9; Belongs to the peptidase C14A family. (440 aa)
Casp2Caspase-2 isoform X1; Belongs to the peptidase C14A family. (452 aa)
Casp6Caspase-6; Belongs to the peptidase C14A family. (276 aa)
Casp7Caspase-7 subunit p11; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP- ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death (By similarity). (297 aa)
Casp1Caspase-1-like; Belongs to the peptidase C14A family. (313 aa)
Casp3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (246 aa)
Malt1Mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X2. (823 aa)
Casp16Zinc finger protein 213 isoform X5; Belongs to the peptidase C14A family. (165 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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