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Dohh Dohh Cyp21a1 Cyp21a1 Cyp2f2 Cyp2f2 LOC101842021 LOC101842021 LOC101823194 LOC101823194 Cyp26c1 Cyp26c1 LOC101831527 LOC101831527 Cyp2g1 Cyp2g1 Cyp4f39 Cyp4f39 Cyp2w1 Cyp2w1 LOC101829291 LOC101829291 Cyp2j6 Cyp2j6 LOC101830438 LOC101830438 LOC101830378 LOC101830378 LOC101826941 LOC101826941 Cyp2r1 Cyp2r1 Fmo1 Fmo1 LOC101842758 LOC101842758 Degs2 Degs2 Fmo6 Fmo6 Th Th Moxd1 Moxd1 Cyp2s1 Cyp2s1 LOC101844221 LOC101844221 LOC101844759 LOC101844759 Cyp17a1 Cyp17a1 LOC101826326 LOC101826326 Cyp2u1 Cyp2u1 Cyp19a1 Cyp19a1 LOC101826047 LOC101826047 Cyp2ab1 Cyp2ab1 Cyp46a1 Cyp46a1 Pam Pam LOC101836914 LOC101836914 Cyp24a1 Cyp24a1 Gm4847 Gm4847 Cyp1b1 Cyp1b1 Cyp1a1 Cyp1a1 LOC101823339 LOC101823339 LOC101827747 LOC101827747 LOC101838830 LOC101838830 Cyp27a1 Cyp27a1 Msmo1 Msmo1 Cyp4x1 Cyp4x1 Cyp4b1 Cyp4b1 Cyp7a1 Cyp7a1 LOC101831958 LOC101831958 Coq6 Coq6 Cyp4a30b Cyp4a30b Fmo9 Fmo9 Cyp3a13 Cyp3a13 Fmo4 Fmo4 Kiaa1191 Kiaa1191 LOC101830103 LOC101830103 Cyp4f13 Cyp4f13 Cyp1a2 Cyp1a2 Cyp4f14 Cyp4f14 Cyp27b1 Cyp27b1 Fmo2 Fmo2 LOC101832144 LOC101832144 Cyp2c70 Cyp2c70 Sqle Sqle Fmo3 Fmo3 LOC101830700 LOC101830700 Cyp26a1 Cyp26a1 Cyp4f40 Cyp4f40 LOC101843716 LOC101843716 Cyp26b1 Cyp26b1 LOC101844487 LOC101844487 LOC101831088 LOC101831088 LOC101825889 LOC101825889 Kmo Kmo Coq7 Coq7 Agmo Agmo
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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DohhDeoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor; Belongs to the deoxyhypusine hydroxylase family. (302 aa)
Cyp21a1Steroid 21-hydroxylase isoform X2; Belongs to the cytochrome P450 family. (496 aa)
Cyp2f2Cytochrome P450 2F2; Belongs to the cytochrome P450 family. (491 aa)
LOC101842021Cytochrome P450 2C26-like; Belongs to the cytochrome P450 family. (217 aa)
LOC101823194Cytochrome P450 4A12; Belongs to the cytochrome P450 family. (508 aa)
Cyp26c1Cytochrome P450 26C1; Belongs to the cytochrome P450 family. (516 aa)
LOC101831527Cytochrome P450 2C19-like; Belongs to the cytochrome P450 family. (490 aa)
Cyp2g1Cytochrome P450 2G1 isoform X1; Belongs to the cytochrome P450 family. (494 aa)
Cyp4f39Cytochrome P450 4F22; Belongs to the cytochrome P450 family. (532 aa)
Cyp2w1Cytochrome P450 2W1; Belongs to the cytochrome P450 family. (493 aa)
LOC101829291Cytochrome P450 4F5-like; Belongs to the cytochrome P450 family. (524 aa)
Cyp2j6Cytochrome P450 2J6-like; Belongs to the cytochrome P450 family. (421 aa)
LOC101830438Cytochrome P450 2J3-like isoform X1; Belongs to the cytochrome P450 family. (502 aa)
LOC101830378Cytochrome P450 2C26-like isoform X2; Belongs to the cytochrome P450 family. (490 aa)
LOC101826941Cytochrome P450 2A3-like; Belongs to the cytochrome P450 family. (494 aa)
Cyp2r1Vitamin D 25-hydroxylase; Belongs to the cytochrome P450 family. (501 aa)
Fmo1Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
LOC101842758Cytochrome P450 4V2; Belongs to the cytochrome P450 family. (522 aa)
Degs2Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2. (311 aa)
Fmo6Dimethylaniline monooxygenase [N-oxide-forming]. (533 aa)
ThTyrosine 3-monooxygenase. (498 aa)
Moxd1DBH-like monooxygenase protein 1. (613 aa)
Cyp2s1Cytochrome P450 2S1 isoform X1; Belongs to the cytochrome P450 family. (500 aa)
LOC101844221Cytochrome P450 2B1-like; Belongs to the cytochrome P450 family. (491 aa)
LOC101844759Cytochrome P450 2B1-like; Belongs to the cytochrome P450 family. (491 aa)
Cyp17a1Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] (431 aa)
LOC101826326Cytochrome P450 2A9; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (493 aa)
Cyp2u1Cytochrome P450 2U1; Belongs to the cytochrome P450 family. (532 aa)
Cyp19a1Aromatase; Belongs to the cytochrome P450 family. (503 aa)
LOC101826047Lanosterol 14-alpha demethylase; Belongs to the cytochrome P450 family. (200 aa)
Cyp2ab1Cytochrome P450 2J2-like; Belongs to the cytochrome P450 family. (280 aa)
Cyp46a1Cholesterol 24-hydroxylase; Belongs to the cytochrome P450 family. (500 aa)
PamPeptidyl-glycine alpha-amidating monooxygenase isoform X1. (980 aa)
LOC101836914Cytochrome P450 3A31; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (473 aa)
Cyp24a11,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (514 aa)
Gm4847Dimethylaniline monooxygenase [N-oxide-forming]. (538 aa)
Cyp1b1Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (541 aa)
Cyp1a1Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] (507 aa)
LOC101823339Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] (319 aa)
LOC101827747Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa)
LOC101838830LOW QUALITY PROTEIN: cytochrome P450 2D20-like; Belongs to the cytochrome P450 family. (476 aa)
Cyp27a1Sterol 26-hydroxylase, mitochondrial isoform X1; Belongs to the cytochrome P450 family. (534 aa)
Msmo1Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. (293 aa)
Cyp4x1Cytochrome P450 4X1; Belongs to the cytochrome P450 family. (505 aa)
Cyp4b1Cytochrome P450 4B1; Belongs to the cytochrome P450 family. (509 aa)
Cyp7a1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
LOC101831958Lithocholate 6-beta-hydroxylase; Catalyzes the 6 beta-hydroxylation of lithocholic acid and steroid hormones; Belongs to the cytochrome P450 family. (503 aa)
Coq6Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (471 aa)
Cyp4a30bCytochrome P450 4A14-like; Belongs to the cytochrome P450 family. (477 aa)
Fmo9Flavin-containing monooxygenase. (539 aa)
Cyp3a13Cytochrome P450 3A9. (503 aa)
Fmo4Dimethylaniline monooxygenase [N-oxide-forming]. (557 aa)
Kiaa1191Putative monooxygenase p33MONOX isoform X1. (133 aa)
LOC101830103Cytochrome P450 4F5 isoform X1; Belongs to the cytochrome P450 family. (524 aa)
Cyp4f13Cytochrome P450 4F6 isoform X1; Belongs to the cytochrome P450 family. (524 aa)
Cyp1a2Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] (513 aa)
Cyp4f14leukotriene-B4 omega-hydroxylase 3 isoform X2; Belongs to the cytochrome P450 family. (524 aa)
Cyp27b125-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (508 aa)
Fmo2Dimethylaniline monooxygenase [N-oxide-forming]. (535 aa)
LOC101832144Cytochrome P450 2C28; Catalyzes the N-demethylation of aminopyrine and benzphetamine, but does not catalyze the hydroxylation of tolbutamide, testosterone, and progesterone; Belongs to the cytochrome P450 family. (490 aa)
Cyp2c70Cytochrome P450 2C70-like; Belongs to the cytochrome P450 family. (489 aa)
SqleSqualene monooxygenase. (573 aa)
Fmo3Dimethylaniline monooxygenase [N-oxide-forming]. (533 aa)
LOC101830700Cytochrome P450 2J3 isoform X1; Belongs to the cytochrome P450 family. (502 aa)
Cyp26a1Cytochrome P450 26A1; Belongs to the cytochrome P450 family. (497 aa)
Cyp4f40Cytochrome P450 4F4-like; Belongs to the cytochrome P450 family. (532 aa)
LOC101843716Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. (493 aa)
Cyp26b1Cytochrome P450 26B1; Belongs to the cytochrome P450 family. (512 aa)
LOC101844487Cytochrome P450, family 2 subfamily B polypeptide 29; Belongs to the cytochrome P450 family. (491 aa)
LOC101831088Cytochrome P450 2C26; Catalyzes the hydroxylation of tolbutamide and the N- demethylation of aminopyrine and benzphetamine. (490 aa)
LOC101825889Cytochrome P450 2A8; Highly active in 7-ethoxycoumarin O-deethylation, and benzphetamine N-demethylation; moderately active in testosterone 7- alpha-hydroxylation, ethylmorphine N-demethylation, p-nitroanisole O- demethylation; and only slightly active in benzopyrene 3-hydroxylation, 7-ethoxyresorufin O-deethylation, testosterone 2-alpha-hydroxylation and testosterone 17-oxidation. Competent in the metabolic activation of aflatoxin B1; Belongs to the cytochrome P450 family. (494 aa)
KmoKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (479 aa)
Coq75-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (216 aa)
AgmoAlkylglycerol monooxygenase; Belongs to the sterol desaturase family. (449 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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