38 items (Mesocricetus auratus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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gene fusions

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Your Input:
	Pole3	DNA polymerase epsilon subunit 3. (146 aa)
	Rpa3	Replication protein A 14 kDa subunit. (121 aa)
	ENSMAUP00000001221	annotation not available (406 aa)
	Pole2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (461 aa)
	ENSMAUP00000002060	annotation not available (103 aa)
	ENSMAUP00000002256	annotation not available (75 aa)
	Pole4	DNA polymerase epsilon subunit 4. (124 aa)
	Cul4b	cullin-4B; Belongs to the cullin family. (555 aa)
	Kxd1	ubiquitin-60S ribosomal protein L40. (232 aa)
	Rpa2	Replication protein A 32 kDa subunit. (270 aa)
	ENSMAUP00000003260	annotation not available (95 aa)
	Pold1	DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol- delta4), displays differences in catalytic activity. Most notably, expresses higher pro [...] (1101 aa)
	Rfc4	Replication factor C subunit 4. (362 aa)
	Rps27a	ubiquitin-40S ribosomal protein S27a. (156 aa)
	Pold2	DNA polymerase delta subunit 2 isoform X2. (260 aa)
	LOC101823019	Ubiquitin-like. (114 aa)
	ENSMAUP00000006950	annotation not available (259 aa)
	ENSMAUP00000007258	annotation not available (117 aa)
	Usp1	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (783 aa)
	Rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (601 aa)
	Pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	Rbx1	E3 ubiquitin-protein ligase RBX1. (108 aa)
	Ddb1	DNA damage-binding protein 1 isoform X2. (1140 aa)
	Rcbtb2	RCC1 and BTB domain-containing protein 2 isoform X4. (551 aa)
	Pold3	DNA polymerase delta subunit 3 isoform X1. (462 aa)
	Rfc1	Replication factor C subunit 1. (1063 aa)
	Pold4	DNA polymerase delta subunit 4. (74 aa)
	Rfc3	Replication factor C subunit 3. (356 aa)
	Wdr48	WD repeat-containing protein 48 isoform X2. (678 aa)
	ENSMAUP00000019431	annotation not available (150 aa)
	Pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (663 aa)
	Rcbtb1	RCC1 and BTB domain-containing protein 1 isoform X2. (531 aa)
	Atad5	ATPase family AAA domain-containing protein 5. (1819 aa)
	ENSMAUP00000022314	annotation not available (101 aa)
	ENSMAUP00000022826	annotation not available (193 aa)
	Rad18	E3 ubiquitin-protein ligase RAD18 isoform X2. (453 aa)
	Dtl	Denticleless protein homolog. (124 aa)
	Meiob	Meiosis-specific with OB domain-containing protein isoform X1. (470 aa)

Your Current Organism:

Mesocricetus auratus

NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atad5	Cul4b	ENSMAUP00000021981	ENSMAUP00000002767	ATPase family AAA domain-containing protein 5.	cullin-4B; Belongs to the cullin family.	0.663
Atad5	Ddb1	ENSMAUP00000021981	ENSMAUP00000012727	ATPase family AAA domain-containing protein 5.	DNA damage-binding protein 1 isoform X2.	0.650
Atad5	Dtl	ENSMAUP00000021981	ENSMAUP00000024102	ATPase family AAA domain-containing protein 5.	Denticleless protein homolog.	0.881
Atad5	ENSMAUP00000001221	ENSMAUP00000021981	ENSMAUP00000001221	ATPase family AAA domain-containing protein 5.	annotation not available	0.851
Atad5	ENSMAUP00000002060	ENSMAUP00000021981	ENSMAUP00000002060	ATPase family AAA domain-containing protein 5.	annotation not available	0.687
Atad5	ENSMAUP00000006950	ENSMAUP00000021981	ENSMAUP00000006950	ATPase family AAA domain-containing protein 5.	annotation not available	0.997
Atad5	ENSMAUP00000019431	ENSMAUP00000021981	ENSMAUP00000019431	ATPase family AAA domain-containing protein 5.	annotation not available	0.634
Atad5	ENSMAUP00000022826	ENSMAUP00000021981	ENSMAUP00000022826	ATPase family AAA domain-containing protein 5.	annotation not available	0.851
Atad5	Meiob	ENSMAUP00000021981	ENSMAUP00000025186	ATPase family AAA domain-containing protein 5.	Meiosis-specific with OB domain-containing protein isoform X1.	0.866
Atad5	Pcna	ENSMAUP00000021981	ENSMAUP00000009744	ATPase family AAA domain-containing protein 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.991
Atad5	Pold1	ENSMAUP00000021981	ENSMAUP00000003562	ATPase family AAA domain-containing protein 5.	DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol- delta4), displays differences in catalytic activity. Most notably, expresses higher pro [...]	0.869
Atad5	Pold2	ENSMAUP00000021981	ENSMAUP00000006445	ATPase family AAA domain-containing protein 5.	DNA polymerase delta subunit 2 isoform X2.	0.743
Atad5	Pole	ENSMAUP00000021981	ENSMAUP00000020680	ATPase family AAA domain-containing protein 5.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.851
Atad5	Pole2	ENSMAUP00000021981	ENSMAUP00000001461	ATPase family AAA domain-containing protein 5.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.858
Atad5	Pole3	ENSMAUP00000021981	ENSMAUP00000000418	ATPase family AAA domain-containing protein 5.	DNA polymerase epsilon subunit 3.	0.810
Atad5	Pole4	ENSMAUP00000021981	ENSMAUP00000002425	ATPase family AAA domain-containing protein 5.	DNA polymerase epsilon subunit 4.	0.759
Atad5	Rad18	ENSMAUP00000021981	ENSMAUP00000023528	ATPase family AAA domain-containing protein 5.	E3 ubiquitin-protein ligase RAD18 isoform X2.	0.870
Atad5	Rfc1	ENSMAUP00000021981	ENSMAUP00000016418	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 1.	0.663
Atad5	Rfc3	ENSMAUP00000021981	ENSMAUP00000017645	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 3.	0.997
Atad5	Rfc4	ENSMAUP00000021981	ENSMAUP00000003877	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 4.	0.998

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