STRINGSTRING
Rps6ka5 Rps6ka5 LOC101825362 LOC101825362 Nod1 Nod1 Lrrc74a Lrrc74a Tbk1 Tbk1 ENSMAUP00000000836 ENSMAUP00000000836 Tab3 Tab3 Dusp6 Dusp6 Traf2 Traf2 ENSMAUP00000001261 ENSMAUP00000001261 Ager Ager Vwc2 Vwc2 Tonsl Tonsl Traf5 Traf5 Saa3 Saa3 ENSMAUP00000002256 ENSMAUP00000002256 Ly96 Ly96 ENSMAUP00000019431 ENSMAUP00000019431 Rps6ka1 Rps6ka1 Ticam2 Ticam2 Nfkb1 Nfkb1 Lrrc14 Lrrc14 Creb1 Creb1 LOC101829371 LOC101829371 Dusp4 Dusp4 Ticam1 Ticam1 Atf2 Atf2 Casp8 Casp8 Nlrp14 Nlrp14 Ppp4r4 Ppp4r4 Ppp2cb Ppp2cb N4bp1 N4bp1 ENSMAUP00000021418 ENSMAUP00000021418 Birc7 Birc7 Fos Fos Hmgb1 Hmgb1 Atf1 Atf1 Lrrc71 Lrrc71 ENSMAUP00000022314 ENSMAUP00000022314 Irf7 Irf7 Sigirr Sigirr Dusp3 Dusp3 Atf7 Atf7 Map2k3 Map2k3 Dusp7 Dusp7 Nlrp6 Nlrp6 Ube2v1 Ube2v1 Map2k6 Map2k6 Map3k20 Map3k20 Map2k4 Map2k4 Traf3 Traf3 Tab1 Tab1 Chuk Chuk Ppp2r1b Ppp2r1b Irf3 Irf3 Mapk11 Mapk11 Ikbip Ikbip Mapk9 Mapk9 Cd14 Cd14 Mapk1 Mapk1 Tlr4 Tlr4 Mapk10 Mapk10 Tmem189 Tmem189 Map3k7 Map3k7 Bpi Bpi ENSMAUP00000017825 ENSMAUP00000017825 Nfkb2 Nfkb2 Tirap Tirap Mapk14 Mapk14 Peli3 Peli3 Fosl2 Fosl2 Peli2 Peli2 S100b S100b Bpifc Bpifc Relch Relch Mapk15 Mapk15 Rela Rela Rps6ka3 Rps6ka3 Nkiras2 Nkiras2 Vrk3 Vrk3 Ikbkb Ikbkb Nfkbib Nfkbib ENSMAUP00000014485 ENSMAUP00000014485 Khnyn Khnyn Lrrc45 Lrrc45 Rps6ka2 Rps6ka2 App App Irak1 Irak1 Kxd1 Kxd1 Ly86 Ly86 Ptpn4 Ptpn4 Ppp4r1 Ppp4r1 LOC101825710 LOC101825710 Map2k7 Map2k7 Ppp2r1a Ppp2r1a Ube2n Ube2n Nod2 Nod2 Mapkapk3 Mapkapk3 Mapkapk2 Mapkapk2 Traf6 Traf6 Nfkbia Nfkbia Mapk8 Mapk8 Lbp Lbp Jun Jun Tifa Tifa Map3k1 Map3k1 Nkiras1 Nkiras1 Rps27a Rps27a Ube2d3 Ube2d3 Ikbke Ikbke LOC101823019 LOC101823019 Ikbkg Ikbkg Ube2d2b Ube2d2b Ecsit Ecsit Creb5 Creb5 Nlrp9 Nlrp9 Ripk2 Ripk2 ENSMAUP00000007258 ENSMAUP00000007258 Ppp2ca Ppp2ca Ppp2r5d Ppp2r5d Usp18 Usp18 Tab2 Tab2 Lrrc34 Lrrc34 Lrrc74b Lrrc74b Mapk3 Mapk3 Elk1 Elk1 Nlrc5 Nlrc5 Usp14 Usp14 Cd180 Cd180 Tank Tank Peli1 Peli1 Mapk7 Mapk7 ENSMAUP00000012929 ENSMAUP00000012929 Alpk1 Alpk1 LOC101825446 LOC101825446 Sarm1 Sarm1 Ptpn11 Ptpn11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Rps6ka5Ribosomal protein S6 kinase. (849 aa)
LOC101825362Serum amyloid A-5 protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (90 aa)
Nod1Nucleotide-binding oligomerization domain-containing protein 1 isoform X1. (953 aa)
Lrrc74aLeucine-rich repeat-containing protein 74A. (486 aa)
Tbk1Serine/threonine-protein kinase TBK1. (729 aa)
ENSMAUP00000000836annotation not available (122 aa)
Tab3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X2. (715 aa)
Dusp6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (379 aa)
Traf2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
ENSMAUP00000001261annotation not available (61 aa)
AgerAdvanced glycosylation end product-specific receptor. (405 aa)
Vwc2Brorin. (325 aa)
TonslTonsoku-like protein. (1363 aa)
Traf5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (550 aa)
Saa3Serum amyloid A-3 protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (104 aa)
ENSMAUP00000002256annotation not available (75 aa)
Ly96Lymphocyte antigen 96. (74 aa)
ENSMAUP00000019431annotation not available (150 aa)
Rps6ka1Ribosomal protein S6 kinase. (743 aa)
Ticam2TIR domain-containing adapter molecule 2. (233 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit isoform X1. (970 aa)
Lrrc14Leucine-rich repeat-containing protein 14. (493 aa)
Creb1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
LOC101829371NACHT, LRR and PYD domains-containing protein 9B-like isoform X1. (896 aa)
Dusp4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (385 aa)
Ticam1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (733 aa)
Atf2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (480 aa)
Casp8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (481 aa)
Nlrp14NACHT, LRR and PYD domains-containing protein 14 isoform X1. (996 aa)
Ppp4r4Serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1. (875 aa)
Ppp2cbProtein phosphatase 2 catalytic subunit beta. (299 aa)
N4bp1NEDD4-binding protein 1. (873 aa)
ENSMAUP00000021418annotation not available (290 aa)
Birc7Baculoviral IAP repeat-containing protein 7. (285 aa)
FosProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
Hmgb1High mobility group protein B1. (219 aa)
Atf1Cyclic AMP-dependent transcription factor ATF-1 isoform X3. (269 aa)
Lrrc71Leucine-rich repeat-containing protein 71 isoform X3. (559 aa)
ENSMAUP00000022314annotation not available (101 aa)
Irf7Interferon regulatory factor 7 isoform X1. (394 aa)
SigirrSingle Ig IL-1-related receptor isoform X2. (409 aa)
Dusp3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (210 aa)
Atf7Cyclic AMP-dependent transcription factor ATF-7. (385 aa)
Map2k3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
Dusp7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
Nlrp6NACHT, LRR and PYD domains-containing protein 6 isoform X2. (896 aa)
Ube2v1LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 variant 1-like. (121 aa)
Map2k6Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (334 aa)
Map3k20Mitogen-activated protein kinase kinase kinase 20. (762 aa)
Map2k4Dual specificity mitogen-activated protein kinase kinase 4 isoform X2; Belongs to the protein kinase superfamily. (131 aa)
Traf3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
Tab1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (254 aa)
ChukInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
Ppp2r1bSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2. (693 aa)
Irf3Interferon regulatory factor 3 isoform X1. (420 aa)
Mapk11Mitogen-activated protein kinase. (355 aa)
IkbipInhibitor of nuclear factor kappa-B kinase-interacting protein. (345 aa)
Mapk9Mitogen-activated protein kinase. (423 aa)
Cd14Monocyte differentiation antigen CD14. (370 aa)
Mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (358 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
Mapk10Mitogen-activated protein kinase 10. (252 aa)
Tmem189Transmembrane protein 189. (251 aa)
Map3k7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (497 aa)
BpiBactericidal permeability-increasing protein. (481 aa)
ENSMAUP00000017825annotation not available (97 aa)
Nfkb2Nuclear factor NF-kappa-B p100 subunit isoform X2. (898 aa)
TirapToll/interleukin-1 receptor domain-containing adapter protein isoform X2. (245 aa)
Mapk14Mitogen-activated protein kinase. (360 aa)
Peli3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (445 aa)
Fosl2Fos-related antigen 2. (324 aa)
Peli2E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (419 aa)
S100bProtein S100; Belongs to the S-100 family. (92 aa)
BpifcBPI fold-containing family C protein. (507 aa)
RelchlisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X2. (1211 aa)
Mapk15Mitogen-activated protein kinase. (539 aa)
RelaTranscription factor p65 isoform X1. (260 aa)
Rps6ka3Ribosomal protein S6 kinase. (740 aa)
Nkiras2NF-kappa-B inhibitor-interacting Ras-like protein 2. (191 aa)
Vrk3Inactive serine/threonine-protein kinase VRK3 isoform X1. (450 aa)
IkbkbInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (757 aa)
NfkbibNF-kappa-B inhibitor beta. (358 aa)
ENSMAUP00000014485annotation not available (178 aa)
KhnynProtein KHNYN isoform X1. (667 aa)
Lrrc45Leucine-rich repeat-containing protein 45. (670 aa)
Rps6ka2Ribosomal protein S6 kinase. (733 aa)
AppAmyloid beta A4 protein. (751 aa)
Irak1Interleukin-1 receptor-associated kinase 1 isoform X2. (747 aa)
Kxd1ubiquitin-60S ribosomal protein L40. (232 aa)
Ly86Lymphocyte antigen 86. (160 aa)
Ptpn4Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (926 aa)
Ppp4r1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (573 aa)
LOC101825710LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 1b-like. (1162 aa)
Map2k7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (520 aa)
Ppp2r1aSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
Ube2nUbiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
Nod2Nucleotide-binding oligomerization domain-containing protein 2 isoform X2. (1023 aa)
Mapkapk3MAP kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
Mapkapk2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (386 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
NfkbiaNF-kappa-B inhibitor alpha. (314 aa)
Mapk8Mitogen-activated protein kinase. (427 aa)
LbpLipopolysaccharide-binding protein. (481 aa)
JunTranscription factor AP-1; Belongs to the bZIP family. (338 aa)
TifaTRAF-interacting protein with FHA domain-containing protein A. (185 aa)
Map3k1Mitogen-activated protein kinase kinase kinase 1. (1475 aa)
Nkiras1NF-kappa-B inhibitor-interacting Ras-like protein 1. (192 aa)
Rps27aubiquitin-40S ribosomal protein S27a. (156 aa)
Ube2d3Ubiquitin-conjugating enzyme E2 D3; Belongs to the ubiquitin-conjugating enzyme family. (148 aa)
IkbkeInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (715 aa)
LOC101823019Ubiquitin-like. (114 aa)
IkbkgNF-kappa-B essential modulator isoform X1. (412 aa)
Ube2d2bUbiquitin-conjugating enzyme E2 D2B; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
EcsitEvolutionarily conserved signaling intermediate in Toll pathway, mitochondrial. (222 aa)
Creb5Cyclic AMP-responsive element-binding protein 5 isoform X3. (508 aa)
Nlrp9NACHT, LRR and PYD domains-containing protein 9 isoform X1. (954 aa)
Ripk2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (325 aa)
ENSMAUP00000007258annotation not available (117 aa)
Ppp2caSerine/threonine-protein phosphatase. (309 aa)
Ppp2r5dSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (594 aa)
Usp18Ubl carboxyl-terminal hydrolase 18; Belongs to the peptidase C19 family. (60 aa)
Tab2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1. (693 aa)
Lrrc34Leucine-rich repeat-containing protein 34 isoform X2. (415 aa)
Lrrc74bLeucine-rich repeat-containing protein 74B isoform X1. (393 aa)
Mapk3Mitogen-activated protein kinase. (380 aa)
Elk1ETS domain-containing protein Elk-1. (426 aa)
Nlrc5Protein NLRC5 isoform X1. (1833 aa)
Usp14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (493 aa)
Cd180CD180 antigen. (631 aa)
TankTRAF family member-associated NF-kappa-B activator isoform X2. (443 aa)
Peli1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
Mapk7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (806 aa)
ENSMAUP00000012929annotation not available (90 aa)
Alpk1Alpha-protein kinase 1. (1202 aa)
LOC101825446Baculoviral IAP repeat-containing protein 1a-like. (953 aa)
Sarm1Sterile alpha and TIR motif-containing protein 1. (723 aa)
Ptpn11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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